PMC:7311890 / 40247-40709 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T58","span":{"begin":386,"end":389},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T59","span":{"begin":386,"end":389},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T280","span":{"begin":44,"end":49},"obj":"Body_part"},{"id":"T281","span":{"begin":142,"end":147},"obj":"Body_part"},{"id":"T282","span":{"begin":237,"end":242},"obj":"Body_part"},{"id":"T283","span":{"begin":305,"end":309},"obj":"Body_part"}],"attributes":[{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A281","pred":"fma_id","subj":"T281","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T27","span":{"begin":44,"end":49},"obj":"Body_part"},{"id":"T28","span":{"begin":142,"end":147},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T177","span":{"begin":77,"end":85},"obj":"Disease"},{"id":"T178","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T179","span":{"begin":453,"end":461},"obj":"Disease"}],"attributes":[{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A178","pred":"mondo_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A179","pred":"mondo_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T343","span":{"begin":228,"end":236},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T344","span":{"begin":305,"end":314},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T679","span":{"begin":237,"end":242},"obj":"Chemical"},{"id":"T680","span":{"begin":291,"end":294},"obj":"Chemical"},{"id":"T681","span":{"begin":348,"end":352},"obj":"Chemical"},{"id":"T682","span":{"begin":386,"end":389},"obj":"Chemical"}],"attributes":[{"id":"A679","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A680","pred":"chebi_id","subj":"T680","obj":"http://purl.obolibrary.org/obo/CHEBI_17636"},{"id":"A681","pred":"chebi_id","subj":"T681","obj":"http://purl.obolibrary.org/obo/CHEBI_18035"},{"id":"A682","pred":"chebi_id","subj":"T682","obj":"http://purl.obolibrary.org/obo/CHEBI_15681"},{"id":"A683","pred":"chebi_id","subj":"T682","obj":"http://purl.obolibrary.org/obo/CHEBI_84118"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1170","span":{"begin":86,"end":94},"obj":"Species"},{"id":"1172","span":{"begin":291,"end":294},"obj":"Chemical"},{"id":"1173","span":{"begin":299,"end":303},"obj":"Chemical"},{"id":"1174","span":{"begin":348,"end":352},"obj":"Chemical"},{"id":"1175","span":{"begin":386,"end":389},"obj":"Chemical"},{"id":"1181","span":{"begin":77,"end":85},"obj":"Disease"},{"id":"1182","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"1183","span":{"begin":453,"end":461},"obj":"Disease"}],"attributes":[{"id":"A1170","pred":"tao:has_database_id","subj":"1170","obj":"Tax:9606"},{"id":"A1172","pred":"tao:has_database_id","subj":"1172","obj":"MESH:D013109"},{"id":"A1174","pred":"tao:has_database_id","subj":"1174","obj":"MESH:D004075"},{"id":"A1181","pred":"tao:has_database_id","subj":"1181","obj":"MESH:C000657245"},{"id":"A1182","pred":"tao:has_database_id","subj":"1182","obj":"MESH:C000657245"},{"id":"A1183","pred":"tao:has_database_id","subj":"1183","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T62","span":{"begin":437,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T252","span":{"begin":0,"end":462},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T913","span":{"begin":44,"end":49},"obj":"UBERON:0001977"},{"id":"T914","span":{"begin":77,"end":85},"obj":"SP_7"},{"id":"T915","span":{"begin":142,"end":147},"obj":"UBERON:0001977"},{"id":"T916","span":{"begin":185,"end":193},"obj":"SP_7"},{"id":"T917","span":{"begin":219,"end":227},"obj":"GO:0070062"},{"id":"T918","span":{"begin":228,"end":236},"obj":"GO:0016020"},{"id":"T919","span":{"begin":237,"end":242},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T920","span":{"begin":299,"end":303},"obj":"PR:000015682"},{"id":"T921","span":{"begin":348,"end":352},"obj":"CHEBI:17855;CHEBI:17855"},{"id":"T922","span":{"begin":399,"end":407},"obj":"GO:0070062"},{"id":"T923","span":{"begin":453,"end":461},"obj":"SP_7"},{"id":"T22841","span":{"begin":84,"end":88},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T88717","span":{"begin":194,"end":202},"obj":"SP_7"},{"id":"T51146","span":{"begin":314,"end":318},"obj":"CHEBI:18059;CHEBI:18059"},{"id":"T38658","span":{"begin":364,"end":368},"obj":"CHEBI:18059;CHEBI:18059"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}

{"project":"2_test","denotations":[{"id":"32610096-17157973-19699519","span":{"begin":368,"end":372},"obj":"17157973"}],"text":"Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19."}