Our comprehensive, quantitative analyses of serum lipidome and metabolome in COVID-19 patients and healthy controls revealed that the overall serum lipidomic signatures associated with COVID-19 closely mirrored that of exosomal membrane lipid composition, which comprises enhanced levels of SMs and GM3s (cell-type specific) and reduced amounts of DAGs (Subra et al., 2007), indicating GM3-enriched exosomes might be associated with the pathogenesis of COVID-19.