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PMC:7309518 / 15138-17803 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T102 444-450 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T103 616-621 Body_part denotes thigh http://purl.org/sig/ont/fma/fma24967
T104 1107-1113 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T105 1336-1342 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T106 1570-1573 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T107 1774-1780 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T108 1924-1930 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T109 1942-1950 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T110 2258-2264 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T111 2359-2372 Body_part denotes muscle fibers http://purl.org/sig/ont/fma/fma67328
T112 2514-2518 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T113 2561-2566 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T114 2570-2580 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T115 2591-2603 Body_part denotes muscle fiber http://purl.org/sig/ont/fma/fma67328
T116 2647-2656 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T216 26-34 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167
T218 75-83 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T219 95-114 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T220 146-167 Disease denotes inflammatory myopathy http://purl.obolibrary.org/obo/MONDO_0007827
T221 159-167 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T222 203-211 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167
T224 213-216 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T226 236-238 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T227 317-325 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T228 355-363 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T229 375-383 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T230 451-457 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T231 461-475 Disease denotes rhabdomyolysis http://purl.obolibrary.org/obo/MONDO_0005290
T232 523-531 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T233 542-545 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T235 728-730 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T236 766-774 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T237 867-869 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T238 962-970 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T239 980-989 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T240 1015-1017 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T241 1138-1140 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T242 1214-1222 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T243 1273-1286 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T244 1402-1404 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T245 1480-1501 Disease denotes inflammatory myopathy http://purl.obolibrary.org/obo/MONDO_0007827
T246 1493-1501 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T247 1525-1528 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T249 1629-1632 Disease denotes NAM http://purl.obolibrary.org/obo/MONDO_0009722|http://purl.obolibrary.org/obo/MONDO_0016098
T251 1753-1755 Disease denotes CK http://purl.obolibrary.org/obo/MONDO_0017941
T252 1810-1818 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T253 1874-1882 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T254 2128-2136 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T255 2148-2156 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167
T257 2203-2211 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T258 2290-2298 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T259 2424-2432 Disease denotes myositis http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T107 384-387 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T108 435-450 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T109 435-450 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T110 435-450 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T111 616-621 http://www.ebi.ac.uk/efo/EFO_0001943 denotes thigh
T112 818-819 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 892-893 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 925-928 http://purl.obolibrary.org/obo/CLO_0001602 denotes a 6
T115 925-928 http://purl.obolibrary.org/obo/CLO_0001603 denotes a 6
T116 925-928 http://purl.obolibrary.org/obo/CLO_0050248 denotes a 6
T117 925-928 http://purl.obolibrary.org/obo/CLO_0052463 denotes a 6
T118 1107-1113 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T119 1107-1113 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T120 1107-1113 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T121 1107-1113 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T122 1255-1256 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 1336-1342 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T124 1336-1342 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T125 1336-1342 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T126 1336-1342 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T127 1720-1722 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T128 1774-1780 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T129 1774-1780 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T130 1774-1780 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T131 1774-1780 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T132 1839-1840 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 1883-1886 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T134 1924-1930 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T135 1924-1930 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T136 1924-1930 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T137 1924-1930 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T138 2249-2264 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T139 2249-2264 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T140 2249-2264 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T141 2323-2328 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T142 2359-2365 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T143 2359-2365 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T144 2359-2365 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T145 2359-2365 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T146 2386-2393 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T147 2433-2436 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T148 2487-2494 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T149 2512-2518 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T150 2559-2566 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T151 2591-2597 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T152 2591-2597 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T153 2591-2597 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T154 2591-2597 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T92 794-812 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T93 1649-1655 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
547 26-34 Disease denotes myositis MESH:D009220
578 728-730 Gene denotes CK Gene:51727
579 1073-1076 Gene denotes CRP Gene:1401
580 1138-1140 Gene denotes CK Gene:51727
581 1015-1017 Gene denotes CK Gene:51727
582 867-869 Gene denotes CK Gene:51727
583 236-238 Gene denotes CK Gene:51727
584 335-343 Species denotes patients Tax:9606
585 794-812 Chemical denotes hydroxychloroquine MESH:D006886
586 75-83 Disease denotes COVID-19 MESH:C000657245
587 95-114 Disease denotes autoimmune diseases MESH:D001327
588 159-167 Disease denotes myopathy MESH:D009135
589 180-211 Disease denotes necrotizing autoimmune myositis MESH:D020721
590 259-266 Disease denotes myalgia MESH:D063806
591 271-279 Disease denotes weakness MESH:D018908
592 317-334 Disease denotes COVID-19–infected MESH:C000657245
593 355-363 Disease denotes COVID-19 MESH:C000657245
594 375-383 Disease denotes myopathy MESH:D009135
595 435-457 Disease denotes skeletal muscle injury MESH:D005207
596 461-475 Disease denotes rhabdomyolysis MESH:D012206
597 523-531 Disease denotes COVID-19 MESH:C000657245
598 622-630 Disease denotes weakness MESH:D018908
599 635-644 Disease denotes inability MESH:D007319
600 680-685 Disease denotes fever MESH:D005334
601 766-774 Disease denotes COVID-19 MESH:C000657245
602 836-852 Disease denotes painful weakness MESH:D018908
603 944-949 Disease denotes fever MESH:D005334
604 951-956 Disease denotes cough MESH:D003371
605 962-989 Disease denotes COVID-19–positive pneumonia MESH:C000657245
606 1099-1122 Disease denotes painful muscle weakness MESH:D018908
607 1214-1222 Disease denotes COVID-19 MESH:C000657245
627 2192-2197 Gene denotes ACE-2 Gene:59272
628 1402-1404 Gene denotes CK Gene:51727
629 1753-1755 Gene denotes CK Gene:51727
630 1828-1836 Species denotes patients Tax:9606
631 1989-1997 Species denotes patients Tax:9606
632 2203-2211 Species denotes SARS-CoV Tax:694009
633 1233-1251 Disease denotes Myopathic symptoms MESH:D051271
634 1273-1286 Disease denotes viral disease MESH:D001102
635 1336-1351 Disease denotes muscle weakness MESH:D018908
636 1493-1501 Disease denotes myopathy MESH:D009135
637 1570-1573 Disease denotes HIV MESH:D015658
638 1691-1705 Disease denotes paraneoplastic MESH:D010257
639 1766-1789 Disease denotes painful muscle weakness MESH:D018908
640 1810-1818 Disease denotes COVID-19 MESH:C000657245
641 1863-1882 Disease denotes autoimmune myopathy MESH:D009135
642 2128-2136 Disease denotes COVID-19 MESH:C000657245
643 2148-2156 Disease denotes myositis MESH:D009220
644 2290-2298 Disease denotes COVID-19 MESH:C000657245
645 2424-2432 Disease denotes myositis MESH:D009220

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T59 0-48 Sentence denotes What is more to come with myositis in the offing
T60 49-546 Sentence denotes Among the other potential COVID-19–associated autoimmune diseases, the first alarming concern is inflammatory myopathy, especially necrotizing autoimmune myositis (NAM) because very high CK levels >10,000 with myalgia and weakness are now reported in more than 10% of COVID-19–infected patients.6 Although COVID-19–associated myopathy has not yet been studied but only characterized as skeletal muscle injury or rhabdomyolysis,6 2 just published cases suggest an autoimmune COVID-19–triggered NAM.
T61 547-880 Sentence denotes One, an 88-year-old man from New York presented with acute bilateral thigh weakness and inability to get up from the toilet, without fever or other systemic symptoms, and very high CK level (13,581 U/L).20 He was found COVID-19 positive and given hydroxychloroquine, and a week later, his painful weakness improved with CK reduction.
T62 881-1232 Sentence denotes The other, a 60-year-old man from Wuhan had a 6-day history of fever, cough, and COVID-19–positive pneumonia with normal strength and CK; 7 days later, although systemically had improved, his CRP doubled and developed painful muscle weakness with very high CK (11,842 U/L).21 He was given IVIg and his strength improved while became COVID-19 negative.
T63 1233-1910 Sentence denotes Myopathic symptoms in a severe systemic viral disease are multifactorial, but an acute onset of severe muscle weakness with increased inflammatory markers and very high CK levels in the thousands, as described above, is consistent with autoimmune inflammatory myopathy within the spectrum of NAM, similar to what was first reported with HIV early in that epidemic.22,23 The most common causes of NAM are not chronic statin use as overstated, but autoimmune, paraneoplastic, or postviral.22–25 Considering that very high CK level and painful muscle weakness were seen in 10% of COVID-19–positive patients,6 a potentially treatable autoimmune myopathy has been likely overlooked.
T64 1911-2373 Sentence denotes Studies with muscle biopsy and antibody screening are urgently needed in such patients because therapy with IVIg can improve strength, reduce morbidity, and facilitate recovery, as reported in the first 2 cases.20,21 COVID-19–associated myositis is also highly interesting because ACE-2, the SARS-CoV receptor, is reportedly expressed in skeletal muscle.26 If this is confirmed, COVID-19 may represent the first virus directly capable of infecting muscle fibers.
T65 2374-2665 Sentence denotes None of the viruses implicated in viral-triggered myositis has so far been shown to infect muscle27,28; instead, viruses induce an immune T cell with clonal expansion of viral-specific T cells or macrophage-mediated, muscle fiber autoinvasion with abundant proinflammatory cytokines.22,29,30

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T108 26-34 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614
T109 95-114 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T110 146-167 Phenotype denotes inflammatory myopathy http://purl.obolibrary.org/obo/HP_0009071
T111 203-211 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614
T112 259-266 Phenotype denotes myalgia http://purl.obolibrary.org/obo/HP_0003326
T113 375-383 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T114 461-475 Phenotype denotes rhabdomyolysis http://purl.obolibrary.org/obo/HP_0003201
T115 680-685 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T116 944-949 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T117 951-956 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T118 980-989 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T119 1107-1122 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T120 1336-1351 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T121 1480-1501 Phenotype denotes inflammatory myopathy http://purl.obolibrary.org/obo/HP_0009071
T122 1774-1789 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T123 1874-1882 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T124 2148-2156 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614
T125 2424-2432 Phenotype denotes myositis http://purl.obolibrary.org/obo/HP_0100614

2_test

Id Subject Object Predicate Lexical cue
32518172-32382463-75850517 750-752 32382463 denotes 20
32518172-25923553-75850518 1597-1599 25923553 denotes 22
32518172-3464769-75850519 1600-1602 3464769 denotes 23
32518172-25923553-75850520 1720-1722 25923553 denotes 22
32518172-3464769-75850520 1720-1722 3464769 denotes 22
32518172-27147697-75850521 1723-1725 27147697 denotes 25
32518172-32382463-75850522 2122-2124 32382463 denotes 20
32518172-25764065-75850523 2265-2267 25764065 denotes 26
32518172-1349938-75850524 2471-2473 1349938 denotes 27
32518172-8455655-75850525 2474-2476 8455655 denotes 28
32518172-25923553-75850526 2657-2659 25923553 denotes 22
32518172-1859178-75850527 2660-2662 1859178 denotes 29
32518172-17366634-75850528 2663-2665 17366634 denotes 30