PMC:7307149 / 5382-6008 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T36","span":{"begin":265,"end":268},"obj":"Body_part"},{"id":"T37","span":{"begin":311,"end":315},"obj":"Body_part"},{"id":"T38","span":{"begin":496,"end":528},"obj":"Body_part"},{"id":"T39","span":{"begin":530,"end":533},"obj":"Body_part"},{"id":"T40","span":{"begin":581,"end":584},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma84795"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T43","span":{"begin":49,"end":57},"obj":"Disease"},{"id":"T44","span":{"begin":217,"end":225},"obj":"Disease"},{"id":"T45","span":{"begin":606,"end":614},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T60","span":{"begin":309,"end":315},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T61","span":{"begin":444,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T62","span":{"begin":488,"end":495},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T11","span":{"begin":325,"end":334},"obj":"Chemical"},{"id":"T12","span":{"begin":488,"end":495},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-PubTator","denotations":[{"id":"143","span":{"begin":217,"end":227},"obj":"Species"},{"id":"144","span":{"begin":606,"end":616},"obj":"Species"},{"id":"145","span":{"begin":49,"end":57},"obj":"Disease"}],"attributes":[{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"Tax:2697049"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"Tax:2697049"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":193,"end":208},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T8","span":{"begin":325,"end":343},"obj":"http://purl.obolibrary.org/obo/GO_0051607"},{"id":"T9","span":{"begin":496,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0046776"},{"id":"T10","span":{"begin":530,"end":533},"obj":"http://purl.obolibrary.org/obo/GO_0046776"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"LitCovid-sentences","denotations":[{"id":"T39","span":{"begin":0,"end":233},"obj":"Sentence"},{"id":"T40","span":{"begin":234,"end":415},"obj":"Sentence"},{"id":"T41","span":{"begin":416,"end":626},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}

{"project":"2_test","denotations":[{"id":"32303592-12472660-65501634","span":{"begin":229,"end":231},"obj":"12472660"}],"text":"While the details of the clinical picture of the COVID-19 pandemic continue to emerge, there remain substantial unanswered questions regarding the role of individual genetic variability in the immune response against SARS-CoV-2 (51). We hypothesize that individual HLA genotypes may differentially induce the T-cell mediated antiviral response and could potentially alter the course of disease and its transmission. In this study, we performed a comprehensive in silico analysis of viral peptide-major histocompatibility complex (MHC) class I binding affinity across 145 different HLA types for the entire SARS-CoV-2 proteome."}