PMC:7307149 / 11402-12226 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T70","span":{"begin":22,"end":25},"obj":"Body_part"},{"id":"T71","span":{"begin":256,"end":259},"obj":"Body_part"},{"id":"T72","span":{"begin":481,"end":484},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma84795"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T60","span":{"begin":149,"end":157},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T119","span":{"begin":68,"end":73},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T120","span":{"begin":86,"end":94},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T121","span":{"begin":193,"end":201},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T122","span":{"begin":241,"end":242},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T123","span":{"begin":280,"end":281},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T124","span":{"begin":409,"end":417},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T125","span":{"begin":485,"end":486},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T126","span":{"begin":489,"end":490},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T127","span":{"begin":584,"end":592},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T60","span":{"begin":86,"end":94},"obj":"Chemical"},{"id":"T61","span":{"begin":193,"end":201},"obj":"Chemical"},{"id":"T62","span":{"begin":213,"end":215},"obj":"Chemical"},{"id":"T63","span":{"begin":409,"end":417},"obj":"Chemical"},{"id":"T64","span":{"begin":584,"end":592},"obj":"Chemical"}],"attributes":[{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}

{"project":"LitCovid-PubTator","denotations":[{"id":"235","span":{"begin":481,"end":498},"obj":"Gene"},{"id":"236","span":{"begin":68,"end":85},"obj":"Species"},{"id":"237","span":{"begin":149,"end":157},"obj":"Disease"}],"attributes":[{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"Gene:3105"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"Tax:694448"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}

{"project":"LitCovid-sentences","denotations":[{"id":"T68","span":{"begin":0,"end":158},"obj":"Sentence"},{"id":"T69","span":{"begin":159,"end":521},"obj":"Sentence"},{"id":"T70","span":{"begin":522,"end":653},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FIG 3 Distribution of HLA allelic presentations of highly conserved human coronavirus peptides with potential to elicit cross-protective immunity to COVID-19. At right, the number of conserved peptides (see Table S3) that putatively bind to a subset of 89 HLA alleles is shown as a series of horizontal bars, with dark and light shading indicating the number of tightly (\u003c50 nM) and loosely (\u003c500 nM) binding peptides, respectively, and with green, orange, and purple representing HLA-A, -B, and -C alleles, respectively. Alleles are sorted in descending order based on the number of peptides they are anticipated to present (binding affinity, \u003c500 nM). The corresponding allelic frequency in the global population is also shown (left), with the length of each horizontal bar indicating absolute frequency in the population."}