PMC:7306567 / 30317-32058
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T46 | 252-261 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
T47 | 272-280 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T48 | 296-307 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T49 | 345-349 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
T50 | 405-409 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T51 | 440-444 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
T52 | 465-483 | Body_part | denotes | type 2 pneumocytes | http://purl.org/sig/ont/fma/fma62501 |
T53 | 497-502 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T54 | 1127-1132 | Body_part | denotes | Serum | http://purl.org/sig/ont/fma/fma63083 |
T55 | 1158-1163 | Body_part | denotes | Serum | http://purl.org/sig/ont/fma/fma63083 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T41 | 405-409 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T42 | 1127-1132 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T43 | 1158-1163 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
282 | 177-195 | Disease | denotes | SARS-2003-infected | MESH:D045169 |
283 | 215-247 | Disease | denotes | corticosteroids [61] Lymphopenia | MESH:D008231 |
284 | 711-766 | Disease | denotes | Fungal infection Invasive Aspergillus tracheobronchitis | MESH:D000072742 |
285 | 798-836 | Disease | denotes | Invasive Aspergillus tracheobronchitis | MESH:D001228 |
286 | 1193-1201 | Disease | denotes | COVID-19 | MESH:C000657245 |
287 | 1220-1240 | Disease | denotes | Secondary infections | MESH:D060085 |
288 | 1424-1433 | Disease | denotes | mortality | MESH:D003643 |
289 | 1546-1554 | Disease | denotes | COVID-19 | MESH:C000657245 |
290 | 1593-1602 | Disease | denotes | mortality | MESH:D003643 |
291 | 1616-1624 | Disease | denotes | COVID-19 | MESH:C000657245 |
292 | 1712-1721 | Disease | denotes | mortality | MESH:D003643 |
293 | 1732-1740 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T146 | 12-16 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
T147 | 177-181 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T148 | 236-247 | Disease | denotes | Lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
T149 | 711-727 | Disease | denotes | Fungal infection | http://purl.obolibrary.org/obo/MONDO_0002041 |
T150 | 718-727 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T151 | 749-766 | Disease | denotes | tracheobronchitis | http://purl.obolibrary.org/obo/MONDO_0021925 |
T152 | 819-836 | Disease | denotes | tracheobronchitis | http://purl.obolibrary.org/obo/MONDO_0021925 |
T153 | 969-973 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
T154 | 1193-1201 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T155 | 1230-1243 | Disease | denotes | infections In | http://purl.obolibrary.org/obo/MONDO_0005550 |
T156 | 1303-1313 | Disease | denotes | pneumoniae | http://purl.obolibrary.org/obo/MONDO_0005249 |
T157 | 1467-1476 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T158 | 1514-1518 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
T159 | 1546-1554 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T160 | 1563-1567 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
T161 | 1616-1624 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T162 | 1633-1637 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
T163 | 1732-1740 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T201 | 272-280 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T202 | 339-344 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
T203 | 345-349 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
T204 | 385-395 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
T205 | 405-409 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T206 | 405-409 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T207 | 427-434 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airways |
T208 | 440-444 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
T209 | 497-502 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T210 | 674-677 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T211 | 1434-1436 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T212 | 137-151 | Chemical | denotes | corticosteroid | http://purl.obolibrary.org/obo/CHEBI_50858 |
T213 | 160-163 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
T215 | 215-230 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
T216 | 364-376 | Chemical | denotes | sialic acids | http://purl.obolibrary.org/obo/CHEBI_26667 |
T217 | 371-376 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T218 | 548-553 | Chemical | denotes | NADPH | http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783 |
T220 | 624-634 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
T221 | 1020-1023 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T222 | 1024-1026 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120|http://purl.obolibrary.org/obo/CHEBI_27680 |
T224 | 1051-1054 | Chemical | denotes | BAL | http://purl.obolibrary.org/obo/CHEBI_64198 |
T225 | 1055-1057 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120|http://purl.obolibrary.org/obo/CHEBI_27680 |
T227 | 1133-1135 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120|http://purl.obolibrary.org/obo/CHEBI_27680 |
T229 | 1164-1166 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120|http://purl.obolibrary.org/obo/CHEBI_27680 |
LitCovid-PD-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T29 | 1024-1026 | GlycoEpitope | denotes | GM | http://www.glycoepitope.jp/epitopes/EP0510 |
T30 | 1055-1057 | GlycoEpitope | denotes | GM | http://www.glycoepitope.jp/epitopes/EP0510 |
T31 | 1133-1135 | GlycoEpitope | denotes | GM | http://www.glycoepitope.jp/epitopes/EP0510 |
T32 | 1164-1166 | GlycoEpitope | denotes | GM | http://www.glycoepitope.jp/epitopes/EP0510 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T41 | 160-163 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
T42 | 236-247 | Phenotype | denotes | Lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
T43 | 1303-1313 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T219 | 0-16 | Sentence | denotes | Factor IAPA CAPA |
T220 | 17-115 | Sentence | denotes | Host/Risk 57% EORTC/MSGERC host factor negative [9] 85% EORTC/MSGERC host factor negative [59, 60] |
T221 | 116-235 | Sentence | denotes | IAPA associated with corticosteroid use [7] IPA developed in SARS-2003-infected patients receiving corticosteroids [61] |
T222 | 236-338 | Sentence | denotes | Lymphopenia and chemokine-producing monocyte-derived FCN1 + macrophages causing hyperinflammation [62] |
T223 | 339-507 | Sentence | denotes | Virus Cell entry through sialic acids-2,6Gal: epithelial layer in lung including larger airways [63] Cell entry through ACE2: type 2 pneumocytes and ciliated cells [64] |
T224 | 508-710 | Sentence | denotes | Immune modulation by suppression of the NADPH oxidase complex [65] No evidence for immunomodulatory effect on known antifungal host defense mechanisms, although this has not been extensively studied yet |
T225 | 711-862 | Sentence | denotes | Fungal infection Invasive Aspergillus tracheobronchitis in up to 55% of patients [7–9] Invasive Aspergillus tracheobronchitis not yet reported [59, 60] |
T226 | 863-995 | Sentence | denotes | Median time between ICU admission and IAPA diagnosis 2–3 days [7–9] Median time between ICU admission and CAPA diagnosis 6 days [59] |
T227 | 996-1126 | Sentence | denotes | Aspergillus diagnostics BAL GM positive in > 88% [7–9] BAL GM commonly positive, diagnostic performance currently unknown [59, 60] |
T228 | 1127-1219 | Sentence | denotes | Serum GM positive in 65% [7–9] Serum GM positive in 3 of 14 (21%) COVID-19 patients [59, 60] |
T229 | 1220-1419 | Sentence | denotes | Secondary infections In 80 of 342 (23.4%) ICU patients, most frequent pathogens S. pneumoniae, Pseudomonas aeruginosa and S. aureus [66] In four of 13 (31%) ICU patients, pathogens not specified [67] |
T230 | 1420-1741 | Sentence | denotes | ICU mortality 45% in IAPA compared with 20% in influenza without IAPA (p < 0.0001) [9] 33% in CAPA cases compared with 17% in COVID-19 without CAPA (p = 0.4) [59] (although mortality rates due to COVID-19 without CAPA vary enormous between countries and we have no clear data yet on the true mortality in ICU of COVID-19) |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T288 | 86-90 | GO:0018995 | denotes | host |
T289 | 137-151 | CHEBI:50858;CHEBI:50858 | denotes | corticosteroid |
T290 | 177-181 | SP_10 | denotes | SARS |
T291 | 215-230 | CHEBI:50858;CHEBI:50858 | denotes | corticosteroids |
T292 | 272-280 | CL:0000576 | denotes | monocyte |
T293 | 289-293 | PR:000007437 | denotes | FCN1 |
T294 | 296-307 | CL:0000235 | denotes | macrophages |
T295 | 364-370 | CHEBI:30563;CHEBI:30563 | denotes | sialic |
T296 | 371-376 | CHEBI:41865;CHEBI:41865 | denotes | acids |
T297 | 385-395 | UBERON:0000483 | denotes | epithelial |
T298 | 396-401 | UBERON:0000115 | denotes | layer |
T299 | 405-409 | UBERON:0002048 | denotes | lung |
T300 | 427-434 | UBERON:0001005 | denotes | airways |
T301 | 440-450 | GO:0035376 | denotes | Cell entry |
T302 | 459-463 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T303 | 465-483 | CL:0002063 | denotes | type 2 pneumocytes |
T304 | 488-502 | CL:0000064 | denotes | ciliated cells |
T305 | 515-525 | GO:0065007 | denotes | modulation |
T306 | 548-569 | GO:0043020 | denotes | NADPH oxidase complex |
T307 | 640-647 | GO:0006952 | denotes | defense |
T308 | 749-766 | UBERON:0007196 | denotes | tracheobronchitis |
T309 | 1127-1132 | UBERON:0001977 | denotes | Serum |
T310 | 1158-1163 | UBERON:0001977 | denotes | Serum |
T311 | 1193-1201 | SP_7 | denotes | COVID-19 |
T312 | 1300-1302 | NCBITaxon:4896 | denotes | S. |
T313 | 1303-1313 | NCBITaxon:31031 | denotes | pneumoniae |
T314 | 1315-1326 | NCBITaxon:286 | denotes | Pseudomonas |
T315 | 1327-1337 | NCBITaxon:8296 | denotes | aeruginosa |
T316 | 1342-1343 | NCBITaxon:4932 | denotes | S |
T317 | 1343-1344 | NCBITaxon:4896 | denotes | . |
T318 | 1546-1554 | SP_7 | denotes | COVID-19 |
T319 | 1616-1624 | SP_7 | denotes | COVID-19 |
T320 | 1732-1740 | SP_7 | denotes | COVID-19 |
T342 | 1300-1302 | NCBITaxon:4896 | denotes | S. |
T23407 | 1303-1313 | NCBITaxon:31031 | denotes | pneumoniae |
T35842 | 1315-1326 | NCBITaxon:286 | denotes | Pseudomonas |
T24939 | 1327-1337 | NCBITaxon:8296 | denotes | aeruginosa |
T27555 | 1342-1343 | NCBITaxon:4932 | denotes | S |
T55957 | 1343-1344 | NCBITaxon:4896 | denotes | . |
T31088 | 1546-1554 | SP_7 | denotes | COVID-19 |
T66943 | 1616-1624 | SP_7 | denotes | COVID-19 |
T66351 | 1732-1740 | SP_7 | denotes | COVID-19 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32572532-30076119-47963455 | 66-67 | 30076119 | denotes | 9 |
32572532-32339350-47963456 | 112-114 | 32339350 | denotes | 60 |
32572532-22895826-47963457 | 157-158 | 22895826 | denotes | 7 |
32572532-12890854-47963458 | 232-234 | 12890854 | denotes | 61 |
32572532-16554799-47963459 | 436-438 | 16554799 | denotes | 63 |
32572532-24563256-47963460 | 571-573 | 24563256 | denotes | 65 |
32572532-22895826-47963461 | 793-794 | 22895826 | denotes | 7 |
32572532-28387526-47963461 | 793-794 | 28387526 | denotes | 7 |
32572532-30076119-47963461 | 793-794 | 30076119 | denotes | 7 |
32572532-32339350-47963462 | 859-861 | 32339350 | denotes | 60 |
32572532-22895826-47963463 | 926-927 | 22895826 | denotes | 7 |
32572532-28387526-47963463 | 926-927 | 28387526 | denotes | 7 |
32572532-30076119-47963463 | 926-927 | 30076119 | denotes | 7 |
32572532-22895826-47963464 | 1046-1047 | 22895826 | denotes | 7 |
32572532-28387526-47963464 | 1046-1047 | 28387526 | denotes | 7 |
32572532-30076119-47963464 | 1046-1047 | 30076119 | denotes | 7 |
32572532-32339350-47963465 | 1123-1125 | 32339350 | denotes | 60 |
32572532-22895826-47963466 | 1153-1154 | 22895826 | denotes | 7 |
32572532-28387526-47963466 | 1153-1154 | 28387526 | denotes | 7 |
32572532-30076119-47963466 | 1153-1154 | 30076119 | denotes | 7 |
32572532-32339350-47963467 | 1216-1218 | 32339350 | denotes | 60 |
32572532-27709265-47963468 | 1353-1355 | 27709265 | denotes | 66 |
32572532-31986264-47963469 | 1416-1418 | 31986264 | denotes | 67 |
32572532-30076119-47963470 | 1504-1505 | 30076119 | denotes | 9 |
T1239 | 66-67 | 30076119 | denotes | 9 |
T11993 | 112-114 | 32339350 | denotes | 60 |
T58330 | 157-158 | 22895826 | denotes | 7 |
T34258 | 232-234 | 12890854 | denotes | 61 |
T40916 | 436-438 | 16554799 | denotes | 63 |
T49447 | 571-573 | 24563256 | denotes | 65 |
T76577 | 793-794 | 22895826 | denotes | 7 |
T1286 | 793-794 | 28387526 | denotes | 7 |
T13233 | 793-794 | 30076119 | denotes | 7 |
T5897 | 859-861 | 32339350 | denotes | 60 |
T37794 | 926-927 | 22895826 | denotes | 7 |
T50031 | 926-927 | 28387526 | denotes | 7 |
T83601 | 926-927 | 30076119 | denotes | 7 |
T28555 | 1046-1047 | 22895826 | denotes | 7 |
T74628 | 1046-1047 | 28387526 | denotes | 7 |
T70095 | 1046-1047 | 30076119 | denotes | 7 |
T97225 | 1123-1125 | 32339350 | denotes | 60 |
T50555 | 1153-1154 | 22895826 | denotes | 7 |
T89999 | 1153-1154 | 28387526 | denotes | 7 |
T65385 | 1153-1154 | 30076119 | denotes | 7 |
T41608 | 1216-1218 | 32339350 | denotes | 60 |
T66653 | 1353-1355 | 27709265 | denotes | 66 |
T99520 | 1416-1418 | 31986264 | denotes | 67 |
T87804 | 1504-1505 | 30076119 | denotes | 9 |