PMC:7306567 / 15375-16237
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 160 | 22-26 | Chemical | denotes | IAPA | |
| 161 | 305-317 | Chemical | denotes | Posaconazole | MESH:C101425 |
| 162 | 64-73 | Disease | denotes | pneumonia | MESH:D011014 |
| 163 | 368-383 | Disease | denotes | neutropenic AML | MESH:D015470 |
| 164 | 408-433 | Disease | denotes | graft-versus-host disease | MESH:D006086 |
| 165 | 724-737 | Disease | denotes | malabsorption | MESH:D008286 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T74 | 54-63 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T75 | 64-73 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T76 | 285-287 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T77 | 362-364 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T78 | 380-383 | Disease | denotes | AML | http://purl.obolibrary.org/obo/MONDO_0018874 |
| T79 | 408-433 | Disease | denotes | graft-versus-host disease | http://purl.obolibrary.org/obo/MONDO_0013730 |
| T80 | 724-737 | Disease | denotes | malabsorption | http://purl.obolibrary.org/obo/MONDO_0020598 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T98 | 233-239 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T99 | 497-500 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T100 | 703-704 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T101 | 810-811 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T97 | 78-88 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T98 | 240-256 | Chemical | denotes | antifungal agent | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T99 | 285-287 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T100 | 362-364 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T101 | 597-599 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T102 | 764-766 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 64-73 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T26 | 380-383 | Phenotype | denotes | AML | http://purl.obolibrary.org/obo/HP_0004808 |
| T27 | 724-737 | Phenotype | denotes | malabsorption | http://purl.obolibrary.org/obo/HP_0002024 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T102 | 0-196 | Sentence | denotes | In settings with high IAPA rates in ICU patients with influenza pneumonia, an antifungal prophylaxis strategy might be appropriate, particularly as IAPA typically occurs early after ICU admission. |
| T103 | 197-304 | Sentence | denotes | However, there is currently no mold-active antifungal agent licensed for prophylaxis of IA in ICU patients. |
| T104 | 305-459 | Sentence | denotes | Posaconazole (POS) prophylaxis reduces the prevalence of IA in neutropenic AML patients and those with graft-versus-host disease following alloHCT [2, 3]. |
| T105 | 460-583 | Sentence | denotes | Based on this proof-of-principle, it has been hypothesized that POS prophylaxis can reduce IAPA prevalence in ICU patients. |
| T106 | 584-759 | Sentence | denotes | Intravenous (IV) administration of POS prophylaxis in the ICU is favored in patients on mechanical ventilation or with a high likelihood of malabsorption of oral formulations. |
| T107 | 760-862 | Sentence | denotes | POS IV formulation should be administered through a central catheter due to its acidity (pH 3.2) [42]. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T118 | 305-317 | CHEBI:64355;CHEBI:64355 | denotes | Posaconazole |
| T119 | 741-745 | UBERON:0000165 | denotes | oral |
| T120 | 840-847 | CHEBI:37527;CHEBI:37527 | denotes | acidity |
| T66121 | 305-317 | CHEBI:64355;CHEBI:64355 | denotes | Posaconazole |
| T65652 | 741-745 | UBERON:0000165 | denotes | oral |
| T18742 | 840-847 | CHEBI:37527;CHEBI:37527 | denotes | acidity |