PMC:7306567 / 15329-16237
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7306567","sourcedb":"PMC","sourceid":"7306567","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7306567","text":"Rationale for antifungal prophylaxis for IAPA\nIn settings with high IAPA rates in ICU patients with influenza pneumonia, an antifungal prophylaxis strategy might be appropriate, particularly as IAPA typically occurs early after ICU admission. However, there is currently no mold-active antifungal agent licensed for prophylaxis of IA in ICU patients. Posaconazole (POS) prophylaxis reduces the prevalence of IA in neutropenic AML patients and those with graft-versus-host disease following alloHCT [2, 3]. Based on this proof-of-principle, it has been hypothesized that POS prophylaxis can reduce IAPA prevalence in ICU patients. Intravenous (IV) administration of POS prophylaxis in the ICU is favored in patients on mechanical ventilation or with a high likelihood of malabsorption of oral formulations. POS IV formulation should be administered through a central catheter due to its acidity (pH 3.2) [42].","divisions":[{"label":"title","span":{"begin":0,"end":45}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"160","span":{"begin":68,"end":72},"obj":"Chemical"},{"id":"161","span":{"begin":351,"end":363},"obj":"Chemical"},{"id":"162","span":{"begin":110,"end":119},"obj":"Disease"},{"id":"163","span":{"begin":414,"end":429},"obj":"Disease"},{"id":"164","span":{"begin":454,"end":479},"obj":"Disease"},{"id":"165","span":{"begin":770,"end":783},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:C101425"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D011014"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D015470"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:D006086"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:D008286"},{"subj":"160","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"},{"subj":"162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":100,"end":109},"obj":"Disease"},{"id":"T75","span":{"begin":110,"end":119},"obj":"Disease"},{"id":"T76","span":{"begin":331,"end":333},"obj":"Disease"},{"id":"T77","span":{"begin":408,"end":410},"obj":"Disease"},{"id":"T78","span":{"begin":426,"end":429},"obj":"Disease"},{"id":"T79","span":{"begin":454,"end":479},"obj":"Disease"},{"id":"T80","span":{"begin":770,"end":783},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0018874"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0013730"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0020598"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T98","span":{"begin":279,"end":285},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T99","span":{"begin":543,"end":546},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T100","span":{"begin":749,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T101","span":{"begin":856,"end":857},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T98","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T96","span":{"begin":14,"end":24},"obj":"Chemical"},{"id":"T97","span":{"begin":124,"end":134},"obj":"Chemical"},{"id":"T98","span":{"begin":286,"end":302},"obj":"Chemical"},{"id":"T99","span":{"begin":331,"end":333},"obj":"Chemical"},{"id":"T100","span":{"begin":408,"end":410},"obj":"Chemical"},{"id":"T101","span":{"begin":643,"end":645},"obj":"Chemical"},{"id":"T102","span":{"begin":810,"end":812},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_74062"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_74062"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T25","span":{"begin":110,"end":119},"obj":"Phenotype"},{"id":"T26","span":{"begin":426,"end":429},"obj":"Phenotype"},{"id":"T27","span":{"begin":770,"end":783},"obj":"Phenotype"}],"attributes":[{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0004808"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002024"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T101","span":{"begin":0,"end":45},"obj":"Sentence"},{"id":"T102","span":{"begin":46,"end":242},"obj":"Sentence"},{"id":"T103","span":{"begin":243,"end":350},"obj":"Sentence"},{"id":"T104","span":{"begin":351,"end":505},"obj":"Sentence"},{"id":"T105","span":{"begin":506,"end":629},"obj":"Sentence"},{"id":"T106","span":{"begin":630,"end":805},"obj":"Sentence"},{"id":"T107","span":{"begin":806,"end":908},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T101","pred":"source","obj":"LitCovid-sentences"},{"subj":"T102","pred":"source","obj":"LitCovid-sentences"},{"subj":"T103","pred":"source","obj":"LitCovid-sentences"},{"subj":"T104","pred":"source","obj":"LitCovid-sentences"},{"subj":"T105","pred":"source","obj":"LitCovid-sentences"},{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T118","span":{"begin":351,"end":363},"obj":"CHEBI:64355;CHEBI:64355"},{"id":"T119","span":{"begin":787,"end":791},"obj":"UBERON:0000165"},{"id":"T120","span":{"begin":886,"end":893},"obj":"CHEBI:37527;CHEBI:37527"},{"id":"T66121","span":{"begin":351,"end":363},"obj":"CHEBI:64355;CHEBI:64355"},{"id":"T65652","span":{"begin":787,"end":791},"obj":"UBERON:0000165"},{"id":"T18742","span":{"begin":886,"end":893},"obj":"CHEBI:37527;CHEBI:37527"}],"attributes":[{"subj":"T118","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T119","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T120","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66121","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65652","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18742","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#dd93ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ecc3"},{"id":"LitCovid-PD-CLO","color":"#eca993"},{"id":"LitCovid-PD-CHEBI","color":"#9396ec"},{"id":"LitCovid-PD-HP","color":"#b0ec93"},{"id":"LitCovid-sentences","color":"#ec93ca"},{"id":"LitCovid-PMC-OGER-BB","color":"#93e4ec"}]}]}}