PMC:7306567 / 15329-16237
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 160 | 68-72 | Chemical | denotes | IAPA | |
| 161 | 351-363 | Chemical | denotes | Posaconazole | MESH:C101425 |
| 162 | 110-119 | Disease | denotes | pneumonia | MESH:D011014 |
| 163 | 414-429 | Disease | denotes | neutropenic AML | MESH:D015470 |
| 164 | 454-479 | Disease | denotes | graft-versus-host disease | MESH:D006086 |
| 165 | 770-783 | Disease | denotes | malabsorption | MESH:D008286 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T74 | 100-109 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T75 | 110-119 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T76 | 331-333 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T77 | 408-410 | Disease | denotes | IA | http://purl.obolibrary.org/obo/MONDO_0000240 |
| T78 | 426-429 | Disease | denotes | AML | http://purl.obolibrary.org/obo/MONDO_0018874 |
| T79 | 454-479 | Disease | denotes | graft-versus-host disease | http://purl.obolibrary.org/obo/MONDO_0013730 |
| T80 | 770-783 | Disease | denotes | malabsorption | http://purl.obolibrary.org/obo/MONDO_0020598 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T98 | 279-285 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T99 | 543-546 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T100 | 749-750 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T101 | 856-857 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T96 | 14-24 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T97 | 124-134 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T98 | 286-302 | Chemical | denotes | antifungal agent | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T99 | 331-333 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T100 | 408-410 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T101 | 643-645 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T102 | 810-812 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 110-119 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T26 | 426-429 | Phenotype | denotes | AML | http://purl.obolibrary.org/obo/HP_0004808 |
| T27 | 770-783 | Phenotype | denotes | malabsorption | http://purl.obolibrary.org/obo/HP_0002024 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T101 | 0-45 | Sentence | denotes | Rationale for antifungal prophylaxis for IAPA |
| T102 | 46-242 | Sentence | denotes | In settings with high IAPA rates in ICU patients with influenza pneumonia, an antifungal prophylaxis strategy might be appropriate, particularly as IAPA typically occurs early after ICU admission. |
| T103 | 243-350 | Sentence | denotes | However, there is currently no mold-active antifungal agent licensed for prophylaxis of IA in ICU patients. |
| T104 | 351-505 | Sentence | denotes | Posaconazole (POS) prophylaxis reduces the prevalence of IA in neutropenic AML patients and those with graft-versus-host disease following alloHCT [2, 3]. |
| T105 | 506-629 | Sentence | denotes | Based on this proof-of-principle, it has been hypothesized that POS prophylaxis can reduce IAPA prevalence in ICU patients. |
| T106 | 630-805 | Sentence | denotes | Intravenous (IV) administration of POS prophylaxis in the ICU is favored in patients on mechanical ventilation or with a high likelihood of malabsorption of oral formulations. |
| T107 | 806-908 | Sentence | denotes | POS IV formulation should be administered through a central catheter due to its acidity (pH 3.2) [42]. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T118 | 351-363 | CHEBI:64355;CHEBI:64355 | denotes | Posaconazole |
| T119 | 787-791 | UBERON:0000165 | denotes | oral |
| T120 | 886-893 | CHEBI:37527;CHEBI:37527 | denotes | acidity |
| T66121 | 351-363 | CHEBI:64355;CHEBI:64355 | denotes | Posaconazole |
| T65652 | 787-791 | UBERON:0000165 | denotes | oral |
| T18742 | 886-893 | CHEBI:37527;CHEBI:37527 | denotes | acidity |