PMC:7301188 / 9724-10557
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7301188","sourcedb":"PMC","sourceid":"7301188","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7301188","text":"Upon SARS-CoV-2 entering the body through the angiotensin-converting enzyme 2 (ACE2) receptor adsorbed on the surface of mucosal epithelial cells [7, 8], its pathogen-associated molecular pattern (PAMP) can be quickly recognized by the immune system, and immune response is activated to clear the virus. However, overactivated immune response could cause a cytokine storm. As a result, cytokine storm causes vascular endothelial damage, activates the coagulation system, and inhibits the fibrinolytic and anticoagulating systems. Excessive thromboses in the microvascular system lead to disseminated intravascular coagulation (DIC) and, ultimately, microcirculatory disorder and serious multiple organ dysfunction syndrome [11]. Therefore, early detection and correction of coagulation dysfunction could effectively reduce mortality.","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T62","span":{"begin":5,"end":15},"obj":"SP_7"},{"id":"T63","span":{"begin":46,"end":77},"obj":"PG_10;PR:000003622"},{"id":"T64","span":{"begin":79,"end":83},"obj":"G_3;PG_10;PR:000003622"},{"id":"T65","span":{"begin":121,"end":128},"obj":"CL:0000219;UBERON:0000344"},{"id":"T66","span":{"begin":129,"end":139},"obj":"UBERON:0000483;CL:0000066"},{"id":"T67","span":{"begin":140,"end":145},"obj":"CL:0000066"},{"id":"T68","span":{"begin":197,"end":201},"obj":"PR:000017540"},{"id":"T69","span":{"begin":236,"end":249},"obj":"UBERON:0002405"},{"id":"T70","span":{"begin":255,"end":261},"obj":"UBERON:0002405;GO:0006955"},{"id":"T71","span":{"begin":262,"end":270},"obj":"GO:0006955"},{"id":"T72","span":{"begin":297,"end":302},"obj":"NCBITaxon:10239"},{"id":"T73","span":{"begin":327,"end":333},"obj":"UBERON:0002405;GO:0006955"},{"id":"T74","span":{"begin":334,"end":342},"obj":"GO:0006955"},{"id":"T75","span":{"begin":417,"end":428},"obj":"UBERON:0001986"},{"id":"T76","span":{"begin":451,"end":462},"obj":"GO:0050817"},{"id":"T77","span":{"begin":488,"end":500},"obj":"GO:0042730"},{"id":"T78","span":{"begin":505,"end":520},"obj":"GO:0050817"},{"id":"T79","span":{"begin":540,"end":550},"obj":"GO:0007596"},{"id":"T80","span":{"begin":572,"end":578},"obj":"UBERON:0002049"},{"id":"T81","span":{"begin":614,"end":625},"obj":"GO:0050817"},{"id":"T82","span":{"begin":696,"end":701},"obj":"UBERON:0000062"},{"id":"T83","span":{"begin":774,"end":785},"obj":"GO:0050817"},{"id":"T14036","span":{"begin":5,"end":15},"obj":"SP_7"},{"id":"T34847","span":{"begin":46,"end":77},"obj":"PG_10;PR:000003622"},{"id":"T90610","span":{"begin":79,"end":83},"obj":"G_3;PG_10;PR:000003622"},{"id":"T49124","span":{"begin":121,"end":128},"obj":"CL:0000219;UBERON:0000344"},{"id":"T79134","span":{"begin":129,"end":139},"obj":"UBERON:0000483;CL:0000066"},{"id":"T19986","span":{"begin":140,"end":145},"obj":"CL:0000066"},{"id":"T31255","span":{"begin":197,"end":201},"obj":"PR:000017540"},{"id":"T47825","span":{"begin":236,"end":249},"obj":"UBERON:0002405"},{"id":"T35483","span":{"begin":255,"end":261},"obj":"UBERON:0002405;GO:0006955"},{"id":"T70637","span":{"begin":262,"end":270},"obj":"GO:0006955"},{"id":"T26218","span":{"begin":297,"end":302},"obj":"NCBITaxon:10239"},{"id":"T6087","span":{"begin":327,"end":333},"obj":"UBERON:0002405;GO:0006955"},{"id":"T65360","span":{"begin":334,"end":342},"obj":"GO:0006955"},{"id":"T64424","span":{"begin":417,"end":428},"obj":"UBERON:0001986"},{"id":"T91538","span":{"begin":451,"end":462},"obj":"GO:0050817"},{"id":"T61209","span":{"begin":488,"end":500},"obj":"GO:0042730"},{"id":"T1741","span":{"begin":505,"end":520},"obj":"GO:0050817"},{"id":"T24928","span":{"begin":540,"end":550},"obj":"GO:0007596"},{"id":"T35188","span":{"begin":572,"end":578},"obj":"UBERON:0002049"},{"id":"T27616","span":{"begin":614,"end":625},"obj":"GO:0050817"},{"id":"T2954","span":{"begin":696,"end":701},"obj":"UBERON:0000062"},{"id":"T2895","span":{"begin":774,"end":785},"obj":"GO:0050817"}],"attributes":[{"subj":"T62","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T64","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T67","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T68","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T69","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T71","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T73","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T74","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T75","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T76","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T83","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T14036","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34847","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90610","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49124","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79134","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19986","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31255","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47825","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35483","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70637","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26218","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6087","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65360","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T64424","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T91538","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T61209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1741","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24928","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35188","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27616","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2954","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2895","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":29,"end":33},"obj":"Body_part"},{"id":"T13","span":{"begin":129,"end":145},"obj":"Body_part"},{"id":"T14","span":{"begin":140,"end":145},"obj":"Body_part"},{"id":"T15","span":{"begin":236,"end":249},"obj":"Body_part"},{"id":"T16","span":{"begin":357,"end":365},"obj":"Body_part"},{"id":"T17","span":{"begin":386,"end":394},"obj":"Body_part"},{"id":"T18","span":{"begin":696,"end":701},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67498"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T11","span":{"begin":236,"end":249},"obj":"Body_part"},{"id":"T12","span":{"begin":696,"end":701},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"256","span":{"begin":46,"end":77},"obj":"Gene"},{"id":"257","span":{"begin":79,"end":83},"obj":"Gene"},{"id":"258","span":{"begin":5,"end":15},"obj":"Species"},{"id":"259","span":{"begin":408,"end":435},"obj":"Disease"},{"id":"260","span":{"begin":530,"end":550},"obj":"Disease"},{"id":"261","span":{"begin":587,"end":625},"obj":"Disease"},{"id":"262","span":{"begin":627,"end":630},"obj":"Disease"},{"id":"263","span":{"begin":687,"end":722},"obj":"Disease"},{"id":"264","span":{"begin":774,"end":797},"obj":"Disease"},{"id":"265","span":{"begin":823,"end":832},"obj":"Disease"}],"attributes":[{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"Gene:59272"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"Gene:59272"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"Tax:2697049"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"MESH:D057772"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"MESH:D013927"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"MESH:D004211"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"MESH:D004211"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"MESH:D009102"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"MESH:D001778"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"MESH:D003643"},{"subj":"256","pred":"source","obj":"LitCovid-PubTator"},{"subj":"257","pred":"source","obj":"LitCovid-PubTator"},{"subj":"258","pred":"source","obj":"LitCovid-PubTator"},{"subj":"259","pred":"source","obj":"LitCovid-PubTator"},{"subj":"260","pred":"source","obj":"LitCovid-PubTator"},{"subj":"261","pred":"source","obj":"LitCovid-PubTator"},{"subj":"262","pred":"source","obj":"LitCovid-PubTator"},{"subj":"263","pred":"source","obj":"LitCovid-PubTator"},{"subj":"264","pred":"source","obj":"LitCovid-PubTator"},{"subj":"265","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T77","span":{"begin":5,"end":13},"obj":"Disease"},{"id":"T78","span":{"begin":540,"end":550},"obj":"Disease"},{"id":"T79","span":{"begin":587,"end":631},"obj":"Disease"},{"id":"T80","span":{"begin":687,"end":722},"obj":"Disease"}],"attributes":[{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0001243"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T84","span":{"begin":129,"end":139},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T85","span":{"begin":140,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T86","span":{"begin":236,"end":249},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T87","span":{"begin":274,"end":283},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T88","span":{"begin":297,"end":302},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T89","span":{"begin":355,"end":356},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T90","span":{"begin":376,"end":377},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T91","span":{"begin":437,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T92","span":{"begin":696,"end":701},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T93","span":{"begin":724,"end":726},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"attributes":[{"subj":"T84","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T49","span":{"begin":46,"end":57},"obj":"Chemical"},{"id":"T50","span":{"begin":627,"end":630},"obj":"Chemical"}],"attributes":[{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_4305"},{"id":"A51","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_53092"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":255,"end":270},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T10","span":{"begin":327,"end":342},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T11","span":{"begin":437,"end":462},"obj":"http://purl.obolibrary.org/obo/GO_0050820"},{"id":"T12","span":{"begin":451,"end":462},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T13","span":{"begin":614,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T14","span":{"begin":774,"end":785},"obj":"http://purl.obolibrary.org/obo/GO_0050817"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T103","span":{"begin":0,"end":303},"obj":"Sentence"},{"id":"T104","span":{"begin":304,"end":372},"obj":"Sentence"},{"id":"T105","span":{"begin":373,"end":529},"obj":"Sentence"},{"id":"T106","span":{"begin":530,"end":728},"obj":"Sentence"},{"id":"T107","span":{"begin":729,"end":833},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T103","pred":"source","obj":"LitCovid-sentences"},{"subj":"T104","pred":"source","obj":"LitCovid-sentences"},{"subj":"T105","pred":"source","obj":"LitCovid-sentences"},{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T14","span":{"begin":357,"end":371},"obj":"Phenotype"},{"id":"T15","span":{"begin":386,"end":400},"obj":"Phenotype"},{"id":"T16","span":{"begin":587,"end":625},"obj":"Phenotype"},{"id":"T17","span":{"begin":627,"end":630},"obj":"Phenotype"}],"attributes":[{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0005521"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0005521"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"2_test","denotations":[{"id":"32596339-31996437-7053682","span":{"begin":147,"end":148},"obj":"31996437"},{"id":"32596339-18424768-7053683","span":{"begin":150,"end":151},"obj":"18424768"},{"id":"32596339-12490963-7053684","span":{"begin":724,"end":726},"obj":"12490963"}],"attributes":[{"subj":"32596339-31996437-7053682","pred":"source","obj":"2_test"},{"subj":"32596339-18424768-7053683","pred":"source","obj":"2_test"},{"subj":"32596339-12490963-7053684","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#c5ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93df"},{"id":"LitCovid-PD-UBERON","color":"#93ecdf"},{"id":"LitCovid-PubTator","color":"#ecc593"},{"id":"LitCovid-PD-MONDO","color":"#aa93ec"},{"id":"LitCovid-PD-CLO","color":"#95ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93af"},{"id":"LitCovid-PD-GO-BP","color":"#93c9ec"},{"id":"LitCovid-sentences","color":"#e3ec93"},{"id":"LitCovid-PD-HP","color":"#db93ec"},{"id":"2_test","color":"#93ecc1"}]}]}}