PMC:7299399 / 6678-7573 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":"As shown in Figure 1, the first events of the infection (i.e., the interactions of the virus with the target cells expressing ACE2) are in the process of being elucidated at the molecular level. However, as patients suffering from severe symptoms—which usually develop only after several days or a week—already bear a high viral load in the lungs, there is a pressing need for strategies not only to prevent infection of the host cells but also to attack pre-existing persistent viruses and to prevent life-threatening processes, such as hyperinflammation in the lung and multiple-organ failure.25 Notably, a comprehensive protein–protein interaction (PPI) map of most viral proteins with the human proteome has been established to provide potentially novel targets for treatment employing already U.S. Food and Drug Administration (FDA)-approved drugs via a process known as drug repurposing.26","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T22","span":{"begin":109,"end":114},"obj":"Body_part"},{"id":"T23","span":{"begin":341,"end":346},"obj":"Body_part"},{"id":"T24","span":{"begin":430,"end":435},"obj":"Body_part"},{"id":"T25","span":{"begin":563,"end":567},"obj":"Body_part"},{"id":"T26","span":{"begin":581,"end":586},"obj":"Body_part"},{"id":"T27","span":{"begin":623,"end":630},"obj":"Body_part"},{"id":"T28","span":{"begin":631,"end":638},"obj":"Body_part"},{"id":"T29","span":{"begin":657,"end":660},"obj":"Body_part"},{"id":"T30","span":{"begin":675,"end":683},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma67847"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":563,"end":567},"obj":"Body_part"},{"id":"T10","span":{"begin":581,"end":586},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T38","span":{"begin":46,"end":55},"obj":"Disease"},{"id":"T39","span":{"begin":408,"end":417},"obj":"Disease"},{"id":"T40","span":{"begin":572,"end":594},"obj":"Disease"}],"attributes":[{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T64","span":{"begin":87,"end":92},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T65","span":{"begin":109,"end":114},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T66","span":{"begin":296,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T67","span":{"begin":316,"end":317},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T68","span":{"begin":341,"end":346},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T69","span":{"begin":357,"end":358},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T70","span":{"begin":430,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T71","span":{"begin":479,"end":486},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T72","span":{"begin":563,"end":567},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T73","span":{"begin":563,"end":567},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T74","span":{"begin":581,"end":586},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T75","span":{"begin":607,"end":608},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T76","span":{"begin":693,"end":698},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T77","span":{"begin":708,"end":711},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T78","span":{"begin":857,"end":858},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T24","span":{"begin":623,"end":630},"obj":"Chemical"},{"id":"T25","span":{"begin":631,"end":638},"obj":"Chemical"},{"id":"T26","span":{"begin":652,"end":655},"obj":"Chemical"},{"id":"T28","span":{"begin":675,"end":683},"obj":"Chemical"},{"id":"T29","span":{"begin":847,"end":852},"obj":"Chemical"},{"id":"T30","span":{"begin":876,"end":880},"obj":"Chemical"}],"attributes":[{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_53266"},{"id":"A27","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_60614"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T31","span":{"begin":0,"end":194},"obj":"Sentence"},{"id":"T32","span":{"begin":195,"end":802},"obj":"Sentence"},{"id":"T33","span":{"begin":803,"end":895},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"144","span":{"begin":126,"end":130},"obj":"Gene"},{"id":"145","span":{"begin":207,"end":215},"obj":"Species"},{"id":"146","span":{"begin":693,"end":698},"obj":"Species"},{"id":"147","span":{"begin":46,"end":55},"obj":"Disease"},{"id":"148","span":{"begin":408,"end":417},"obj":"Disease"},{"id":"149","span":{"begin":572,"end":594},"obj":"Disease"}],"attributes":[{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"Gene:59272"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"Tax:9606"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"Tax:9606"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"MESH:D007239"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"MESH:D007239"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"MESH:D009102"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"149","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32519842-32325025-158462","span":{"begin":595,"end":597},"obj":"32325025"}],"attributes":[{"subj":"32519842-32325025-158462","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#eca693","default":true},{"id":"LitCovid-PD-UBERON","color":"#9399ec"},{"id":"LitCovid-PD-MONDO","color":"#b3ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93cd"},{"id":"LitCovid-PD-CHEBI","color":"#93e7ec"},{"id":"LitCovid-sentences","color":"#ecd693"},{"id":"LitCovid-PubTator","color":"#bc93ec"},{"id":"2_test","color":"#93eca2"}]}]}}