PMC:7299399 / 34999-35670 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":" characterized by a wavelength corresponding to its absorption spectrum to generate reactive oxygen species (ROS) in the presence of oxygen, which ultimately results in cell death. Photodynamic therapy is primarily used for the clinical treatment of various oncological disorders.105 It was not until the 1970s that PDT was first used clinically against viruses,106 exploiting ROS production to damage virus proteins, nucleic acids, and—if present—lipids.107 Even though there are research efforts for PDT-based virotherapies against different viruses, including herpes simplex virus, human papilloma virus, and human immunodeficiency virus,106−109 clinical use of PDT is","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T174","span":{"begin":169,"end":173},"obj":"Body_part"},{"id":"T175","span":{"begin":408,"end":416},"obj":"Body_part"}],"attributes":[{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T131","span":{"begin":563,"end":577},"obj":"Disease"},{"id":"T132","span":{"begin":591,"end":600},"obj":"Disease"},{"id":"T133","span":{"begin":618,"end":634},"obj":"Disease"}],"attributes":[{"id":"A131","pred":"mondo_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/MONDO_0004609"},{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0002363"},{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T317","span":{"begin":18,"end":19},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T318","span":{"begin":169,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T319","span":{"begin":354,"end":361},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T320","span":{"begin":402,"end":407},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T321","span":{"begin":544,"end":551},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T322","span":{"begin":578,"end":583},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T323","span":{"begin":585,"end":590},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T324","span":{"begin":601,"end":606},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T325","span":{"begin":612,"end":617},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T326","span":{"begin":635,"end":640},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T317","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T253","span":{"begin":84,"end":107},"obj":"Chemical"},{"id":"T254","span":{"begin":93,"end":99},"obj":"Chemical"},{"id":"T255","span":{"begin":109,"end":112},"obj":"Chemical"},{"id":"T256","span":{"begin":133,"end":139},"obj":"Chemical"},{"id":"T257","span":{"begin":316,"end":319},"obj":"Chemical"},{"id":"T259","span":{"begin":377,"end":380},"obj":"Chemical"},{"id":"T260","span":{"begin":408,"end":416},"obj":"Chemical"},{"id":"T261","span":{"begin":418,"end":431},"obj":"Chemical"},{"id":"T262","span":{"begin":426,"end":431},"obj":"Chemical"},{"id":"T263","span":{"begin":448,"end":454},"obj":"Chemical"},{"id":"T264","span":{"begin":502,"end":505},"obj":"Chemical"},{"id":"T266","span":{"begin":665,"end":668},"obj":"Chemical"}],"attributes":[{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_53228"},{"id":"A258","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_60622"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_53228"},{"id":"A265","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_60622"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_53228"},{"id":"A267","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_60622"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T33","span":{"begin":591,"end":600},"obj":"Phenotype"},{"id":"T34","span":{"begin":618,"end":634},"obj":"Phenotype"}],"attributes":[{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0012740"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002721"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T55","span":{"begin":169,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"attributes":[{"subj":"T55","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"576","span":{"begin":585,"end":606},"obj":"Species"},{"id":"577","span":{"begin":612,"end":640},"obj":"Species"},{"id":"578","span":{"begin":84,"end":107},"obj":"Chemical"},{"id":"579","span":{"begin":109,"end":112},"obj":"Chemical"},{"id":"580","span":{"begin":133,"end":139},"obj":"Chemical"},{"id":"581","span":{"begin":377,"end":380},"obj":"Chemical"},{"id":"582","span":{"begin":448,"end":454},"obj":"Chemical"},{"id":"583","span":{"begin":174,"end":179},"obj":"Disease"}],"attributes":[{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"Tax:10566"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"Tax:12721"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"MESH:D017382"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"MESH:D017382"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"MESH:D010100"},{"id":"A581","pred":"tao:has_database_id","subj":"581","obj":"MESH:D017382"},{"id":"A582","pred":"tao:has_database_id","subj":"582","obj":"MESH:D008055"},{"id":"A583","pred":"tao:has_database_id","subj":"583","obj":"MESH:D003643"},{"subj":"576","pred":"source","obj":"LitCovid-PubTator"},{"subj":"577","pred":"source","obj":"LitCovid-PubTator"},{"subj":"578","pred":"source","obj":"LitCovid-PubTator"},{"subj":"579","pred":"source","obj":"LitCovid-PubTator"},{"subj":"580","pred":"source","obj":"LitCovid-PubTator"},{"subj":"581","pred":"source","obj":"LitCovid-PubTator"},{"subj":"582","pred":"source","obj":"LitCovid-PubTator"},{"subj":"583","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32519842-21617154-158527","span":{"begin":280,"end":283},"obj":"21617154"},{"id":"32519842-12791463-158528","span":{"begin":362,"end":365},"obj":"12791463"},{"id":"32519842-31397467-158529","span":{"begin":455,"end":458},"obj":"31397467"},{"id":"32519842-12791463-158530","span":{"begin":641,"end":644},"obj":"12791463"},{"id":"32519842-22852040-158531","span":{"begin":645,"end":648},"obj":"22852040"}],"attributes":[{"subj":"32519842-21617154-158527","pred":"source","obj":"2_test"},{"subj":"32519842-12791463-158528","pred":"source","obj":"2_test"},{"subj":"32519842-31397467-158529","pred":"source","obj":"2_test"},{"subj":"32519842-12791463-158530","pred":"source","obj":"2_test"},{"subj":"32519842-22852040-158531","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ece593","default":true},{"id":"LitCovid-PD-MONDO","color":"#cb93ec"},{"id":"LitCovid-PD-CLO","color":"#93ecb1"},{"id":"LitCovid-PD-CHEBI","color":"#ec9793"},{"id":"LitCovid-PD-HP","color":"#93a8ec"},{"id":"LitCovid-PD-GO-BP","color":"#c2ec93"},{"id":"LitCovid-PubTator","color":"#ec93dc"},{"id":"2_test","color":"#93ece2"}]}]}}