PMC:7299399 / 29548-30126 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":"One of the main features of COVID-19 is the triggering of a cytokine storm in the body, also known as cytokine release syndrome (CRS), which results from an excessive immune response and leads to the severe deterioration of patient health.25,97,98 This inflammatory storm is one of the major causes of the acute respiratory distress syndrome (ARDS) that is often associated with multiple-organ failure, representing the leading causes of death in critical patients.98 In particular, the role of interleukin (IL)-6 has been highlighted in patients requiring assisted ventilation.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T122","span":{"begin":60,"end":68},"obj":"Body_part"},{"id":"T123","span":{"begin":82,"end":86},"obj":"Body_part"},{"id":"T124","span":{"begin":102,"end":110},"obj":"Body_part"},{"id":"T125","span":{"begin":388,"end":393},"obj":"Body_part"},{"id":"T126","span":{"begin":495,"end":506},"obj":"Body_part"},{"id":"T127","span":{"begin":508,"end":510},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A125","pred":"fma_id","subj":"T125","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma86578"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T30","span":{"begin":388,"end":393},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T109","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"T110","span":{"begin":129,"end":132},"obj":"Disease"},{"id":"T112","span":{"begin":306,"end":341},"obj":"Disease"},{"id":"T113","span":{"begin":312,"end":341},"obj":"Disease"},{"id":"T114","span":{"begin":343,"end":347},"obj":"Disease"},{"id":"T115","span":{"begin":379,"end":401},"obj":"Disease"}],"attributes":[{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0007399"},{"id":"A111","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0017361"},{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0043726"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T277","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T278","span":{"begin":388,"end":393},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T279","span":{"begin":514,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"attributes":[{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T219","span":{"begin":508,"end":510},"obj":"Chemical"}],"attributes":[{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A220","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T24","span":{"begin":60,"end":74},"obj":"Phenotype"},{"id":"T25","span":{"begin":102,"end":127},"obj":"Phenotype"},{"id":"T26","span":{"begin":312,"end":332},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T37","span":{"begin":167,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T37","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T116","span":{"begin":0,"end":578},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T116","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"464","span":{"begin":495,"end":513},"obj":"Gene"},{"id":"468","span":{"begin":224,"end":231},"obj":"Species"},{"id":"469","span":{"begin":456,"end":464},"obj":"Species"},{"id":"470","span":{"begin":538,"end":546},"obj":"Species"},{"id":"474","span":{"begin":28,"end":36},"obj":"Disease"},{"id":"475","span":{"begin":129,"end":132},"obj":"Disease"},{"id":"476","span":{"begin":306,"end":341},"obj":"Disease"},{"id":"477","span":{"begin":343,"end":347},"obj":"Disease"},{"id":"478","span":{"begin":379,"end":401},"obj":"Disease"},{"id":"479","span":{"begin":438,"end":443},"obj":"Disease"}],"attributes":[{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Gene:3569"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"Tax:9606"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"Tax:9606"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"Tax:9606"},{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"MESH:C000657245"},{"id":"A475","pred":"tao:has_database_id","subj":"475","obj":"MESH:D003398"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"MESH:D012128"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"MESH:D012128"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"MESH:D009102"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"MESH:D003643"},{"subj":"464","pred":"source","obj":"LitCovid-PubTator"},{"subj":"468","pred":"source","obj":"LitCovid-PubTator"},{"subj":"469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"479","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32519842-32325025-158521","span":{"begin":239,"end":241},"obj":"32325025"},{"id":"32519842-32192578-158522","span":{"begin":242,"end":244},"obj":"32192578"}],"attributes":[{"subj":"32519842-32325025-158521","pred":"source","obj":"2_test"},{"subj":"32519842-32192578-158522","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d6ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#e893ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecce"},{"id":"LitCovid-PD-CLO","color":"#ecb493"},{"id":"LitCovid-PD-CHEBI","color":"#9a93ec"},{"id":"LitCovid-PD-HP","color":"#a6ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93c0"},{"id":"LitCovid-sentences","color":"#93daec"},{"id":"LitCovid-PubTator","color":"#ece493"},{"id":"2_test","color":"#ca93ec"}]}]}}