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PMC:7299399 / 2339-11388 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T28998 156-161 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T99009 189-194 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 412-416 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T6 728-732 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T7 2402-2408 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T8 2591-2596 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T9 2792-2797 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T10 2799-2805 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T11 2807-2810 Body_part denotes eye http://purl.org/sig/ont/fma/fma54448
T12 2833-2838 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T13 3020-3026 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T14 3316-3321 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 3411-3416 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16 3516-3523 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 3688-3695 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 3938-3945 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 4039-4044 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 4113-4120 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 4216-4223 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T22 4448-4453 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23 4680-4685 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T24 4769-4774 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 4902-4906 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T26 4920-4925 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T27 4962-4969 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 4970-4977 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T29 4996-4999 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T30 5014-5022 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T31 5395-5407 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T32 5395-5399 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T33 5423-5429 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T34 5560-5569 Body_part denotes endosomes http://purl.org/sig/ont/fma/fma67180
T35 5592-5601 Body_part denotes endosomes http://purl.org/sig/ont/fma/fma67180
T36 5646-5652 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T37 5669-5676 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 5704-5707 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T39 5712-5719 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 6945-6948 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T41 7327-7332 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T42 7474-7478 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T43 7488-7493 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T44 7854-7872 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T45 8135-8142 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 2402-2408 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T3 2591-2596 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T4 2773-2779 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T5 2792-2797 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T6 2799-2805 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T7 2807-2810 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T8 2833-2838 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T9 4902-4906 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 4920-4925 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T11 7474-7478 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T12 7488-7493 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T13 7854-7872 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T14 8615-8620 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T10 0-8 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 957-963 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T12 1150-1166 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T13 1631-1640 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T14 1813-1821 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 1966-1974 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1978-2002 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T17 2005-2013 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 2056-2064 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 2102-2110 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 2181-2191 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T21 2252-2260 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 2397-2408 Disease denotes sore throat http://purl.obolibrary.org/obo/MONDO_0002258
T23 2420-2428 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T24 2554-2566 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T25 2568-2576 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T26 2582-2604 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T27 2591-2604 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T28 2731-2739 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 2812-2826 Disease denotes conjunctivitis http://purl.obolibrary.org/obo/MONDO_0003799
T30 2840-2852 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T31 2924-2932 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 3030-3038 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 3152-3172 Disease denotes respiratory diseases http://purl.obolibrary.org/obo/MONDO_0005087
T34 3181-3189 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 3232-3240 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 3528-3536 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 3739-3748 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 4385-4394 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 4747-4756 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 4911-4933 Disease denotes multiple-organ failure http://purl.obolibrary.org/obo/MONDO_0043726
T41 5245-5253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 5314-5322 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 5735-5745 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T44 6086-6094 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 6214-6230 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T46 6287-6295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 6956-6965 Disease denotes papilloma http://purl.obolibrary.org/obo/MONDO_0002363
T48 6973-6987 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T49 7097-7105 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T50 7393-7402 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 7731-7739 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T52 7836-7844 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 8353-8361 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 8364-8373 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 8418-8427 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 9018-9026 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T9480 87-94 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T76610 107-108 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27092 156-161 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T40144 189-194 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T25132 200-210 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T36336 313-318 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T52287 412-416 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T87895 620-627 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T98694 648-653 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T91178 684-685 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1071 728-732 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T33608 939-945 http://purl.obolibrary.org/obo/UBERON_0007688 denotes fields
T11702 1141-1148 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T55123 1419-1424 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T75987 1451-1458 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T72248 1603-1604 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T89142 1695-1697 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T91483 1767-1772 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T532 1804-1809 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T96901 1914-1926 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T41707 2025-2027 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T31 2074-2075 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 2113-2116 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33 2228-2230 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T34 2591-2596 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T35 2591-2596 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T36 2591-2596 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T37 2591-2596 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T38 2773-2779 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T39 2792-2797 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T40 2792-2797 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T41 2792-2797 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T42 2792-2797 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T43 2799-2805 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T44 2799-2805 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T45 2799-2805 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T46 2807-2810 http://www.ebi.ac.uk/efo/EFO_0000827 denotes eye
T47 2833-2838 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T48 2833-2838 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T49 2857-2859 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T50 3041-3044 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T51 3078-3079 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 3113-3118 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T53 3251-3252 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 3271-3276 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T55 3310-3321 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T56 3411-3416 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T57 3510-3515 http://purl.obolibrary.org/obo/CLO_0050050 denotes (S) 1
T58 3787-3792 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T59 3961-3962 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 3994-3999 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 4039-4044 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62 4274-4282 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T63 4330-4335 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T64 4426-4431 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T65 4448-4453 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T66 4635-4636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 4655-4656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68 4680-4685 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T69 4696-4697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 4769-4774 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T71 4818-4825 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T72 4902-4906 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T73 4902-4906 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T74 4920-4925 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T75 4946-4947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 5032-5037 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T77 5047-5050 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T78 5196-5197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 5395-5399 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T80 5495-5503 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T81 5926-5927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 6165-6168 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T83 6354-6357 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T84 6496-6497 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 6522-6529 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T86 6557-6559 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T87 6698-6703 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 6727-6728 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 6758-6765 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T90 6915-6920 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T91 6950-6955 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T92 6966-6971 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T93 7005-7012 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T94 7016-7018 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T95 7142-7143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 7327-7332 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T97 7377-7382 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T98 7438-7443 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T99 7474-7478 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T100 7488-7493 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T101 7488-7493 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T102 7605-7610 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T103 7854-7872 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T104 8468-8471 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T105 8591-8592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11 558-562 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T12 989-997 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T13 1513-1517 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14 1596-1601 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T15 2886-2891 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 2996-3004 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T17 3323-3334 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T18 3353-3355 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T19 3516-3523 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 3688-3695 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 3938-3945 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 4113-4120 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 4216-4223 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 4962-4969 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 4970-4977 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26 4991-4994 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T28 5014-5022 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T29 5186-5191 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T30 5215-5219 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T31 5334-5345 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 5423-5429 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T33 5669-5676 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34 5712-5719 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35 5811-5820 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T36 6017-6022 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T37 6277-6282 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T38 6405-6414 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T39 6643-6648 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T40 7193-7198 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T41 7275-7285 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T42 7918-7923 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T43 8047-8060 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T44 8062-8065 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T45 8075-8086 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T46 8135-8142 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47 8245-8248 Chemical denotes NPs http://purl.obolibrary.org/obo/CHEBI_50803
T48 8429-8432 Chemical denotes PDT http://purl.obolibrary.org/obo/CHEBI_53228|http://purl.obolibrary.org/obo/CHEBI_60622

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 957-963 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T3 1513-1527 Phenotype denotes drug resistant http://purl.obolibrary.org/obo/HP_0020174
T4 1631-1640 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 2265-2270 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T6 2280-2285 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T7 2299-2306 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T8 2351-2358 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T9 2360-2368 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T10 2397-2408 Phenotype denotes sore throat http://purl.obolibrary.org/obo/HP_0033050
T11 2410-2418 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T12 2420-2428 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T13 2430-2440 Phenotype denotes rhinorrhea http://purl.obolibrary.org/obo/HP_0031417
T14 2446-2460 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T15 2554-2566 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T16 2812-2826 Phenotype denotes conjunctivitis http://purl.obolibrary.org/obo/HP_0000509
T17 2840-2852 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T18 6956-6965 Phenotype denotes papilloma http://purl.obolibrary.org/obo/HP_0012740

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 189-210 http://purl.obolibrary.org/obo/GO_0001775 denotes cells; and activation
T4 793-801 http://purl.obolibrary.org/obo/GO_0007612 denotes learning
T5 1150-1166 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T6 1513-1527 http://purl.obolibrary.org/obo/GO_0042493 denotes drug resistant
T7 3396-3402 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T8 3396-3402 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T9 4022-4028 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T10 4022-4028 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T11 4274-4289 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 5256-5272 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T13 5486-5503 http://purl.obolibrary.org/obo/GO_0008233 denotes protease activity
T14 5669-5686 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T15 5677-5686 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T16 5712-5729 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T17 5720-5729 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18 6214-6230 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T19 8395-8410 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-9 Sentence denotes COVID-19:
T14 10-46 Sentence denotes Setting the Scene for Nanotechnology
T15 47-628 Sentence denotes Through millions of years of evolution, viruses have gained a variety of molecular mechanisms for entry into cells; long-term survival within cells; and activation, inhibition, or modification of the host defense mechanisms at all levels.1 Their ability to transfer genes with high efficiency inspired the development of noninfectious recombinant viral vectors for gene-therapy applications, beginning in 1990.2−4 Efforts were then underway to improve the safety of viral vectors, including developing nonviral drug-delivery systems inspired by the natural capabilities of viruses.
T16 629-789 Sentence denotes Researchers in the field of nanomedicine have designed a variety of nanosystems that can mimic the gene-transfer capacity and high infectivity of viral vectors.
T17 790-1149 Sentence denotes By learning the molecular mechanisms behind these vectors, nanomedicine and biomedical researchers have developed delivery systems used in different fields, including cancer therapy and regenerative medicine.5,6 However, nanotechnology is not only inspired by virology to develop novel delivery tools but also at the forefront in combatting dangerous viruses.
T18 1150-1436 Sentence denotes Viral infections are one of the leading causes of morbidity and mortality worldwide and one of the main reasons for significant economic losses.7−9 Standard treatment approaches mainly rely on vaccination and therapeutics derived through targeting key processes in the virus life cycle.
T19 1437-1602 Sentence denotes However, many viruses evolve subject to selective pressures, often becoming drug resistant, which necessitates additional resources for the development of new drugs.
T20 1603-1682 Sentence denotes A novel coronavirus causing pneumonia was identified in China in December 2019.
T21 1683-2015 Sentence denotes On February 11, the Coronavirus Study Group (CGS) of the International Committee on Virus Taxonomy (ICTV) designated the virus as SARS-CoV-2 based on phylogeny and taxonomy.10 The same day, the Director General of the World Health Organization (WHO) designated the disease caused by SARS-CoV-2 “coronavirus disease 2019” (COVID-19).
T22 2016-2085 Sentence denotes On March 11, 2020, the WHO declared the COVID-19 outbreak a pandemic.
T23 2086-2230 Sentence denotes As of May 2020, SARS-CoV-2 has spread across the world in over 185 countries, with millions of infections and hundreds of thousands of deaths.11
T24 2231-2315 Sentence denotes The main symptoms of COVID-19 are fever (85.6%), cough (68.7%), and fatigue (39.4%).
T25 2316-2461 Sentence denotes Other less common symptoms include dyspnea, headache, loss of appetite, panting, sore throat, vomiting, diarrhea, rhinorrhea, and abdominal pain.
T26 2462-3015 Sentence denotes The severity of disease in patients depends mainly on the presence of comorbidities such as hypertension, diabetes, and coronary heart disease.12,13 The incubation period is reported to be between 5 and 14 days before disease onset.14 Recent reports indicate that some COVID-19 patients exhibit damage in other organs such as the heart, kidney, eye (conjunctivitis), and brain (encephalitis).15−18 The race is on to develop drugs and treatment options to combat COVID-19, harnessing all of the tools and technologies modern molecular medicine can offer.
T27 3016-3425 Sentence denotes The genome of SARS-CoV-2 has been fully sequenced19 and shows a high degree of similarity in key genes with other coronaviruses causing respiratory diseases such as SARS-CoV.20 Based on knowledge gathered during the SARS-CoV epidemic, a key target of the virus includes the surface receptor in human cells, angiotensin-converting enzyme II (ACE2), which is required for efficient uptake in host cells.19,21−23
T28 3426-3550 Sentence denotes The C-terminal domain (i.e., receptor-binding domain of the envelope-embedded spike (S) 1 protein) of SARS-CoV-2 binds ACE2.
T29 3551-3822 Sentence denotes The molecular details of this interaction have been provided by solving the crystal structure of the complex.24 Because binding of the S protein to ACE2 is critical for the first steps of infection, the most common treatment approaches focus on disrupting this key event.
T30 3823-4338 Sentence denotes At present, there are three main strategies to block ACE2 binding: (i) administration of soluble, recombinant ACE2 protein, which acts as a decoy receptor to scavenge the virus and, thus, to prevent uptake into host cells;21 (ii) vaccination with antibodies that specifically bind to the S protein and interfere with ACE2 interaction; and (iii) inhibition of host proteases that process the S protein and are essential for ACE2 binding and subsequent membrane fusion to enable intracellular delivery of the virus.23
T31 4339-4533 Sentence denotes As shown in Figure 1, the first events of the infection (i.e., the interactions of the virus with the target cells expressing ACE2) are in the process of being elucidated at the molecular level.
T32 4534-5141 Sentence denotes However, as patients suffering from severe symptoms—which usually develop only after several days or a week—already bear a high viral load in the lungs, there is a pressing need for strategies not only to prevent infection of the host cells but also to attack pre-existing persistent viruses and to prevent life-threatening processes, such as hyperinflammation in the lung and multiple-organ failure.25 Notably, a comprehensive protein–protein interaction (PPI) map of most viral proteins with the human proteome has been established to provide potentially novel targets for treatment employing already U.S.
T33 5142-5234 Sentence denotes Food and Drug Administration (FDA)-approved drugs via a process known as drug repurposing.26
T34 5235-5313 Sentence denotes Figure 1 SARS-CoV-2 viral life cycle and potential targets for nanomaterials.
T35 5314-5408 Sentence denotes SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cell surface.
T36 5409-5504 Sentence denotes Transmembrane serine protease 2 (TMPRSS2) facilitates cellular entry through protease activity.
T37 5505-5570 Sentence denotes Later, viral particles are internalized and enter into endosomes.
T38 5571-5687 Sentence denotes Due to the low pH of endosomes, viral particles are uncoated and the viral genome is released for protein synthesis.
T39 5688-5783 Sentence denotes Following viral RNA and protein synthesis, new infectious particles are assembled and released.
T40 5784-6231 Sentence denotes The development process of antiviral therapies typically requires years before the therapies can be made widely available27 because there are a number of regulatory steps required to establish the safety and efficacy of vaccines and drugs.28 Moreover, the highly specific viral targets might change as SARS-CoV-2 continues to mutate, resulting in resistance to medication, such as has been observed when attempting to treat other viral infections.
T41 6232-6327 Sentence denotes Overviews of the identification of candidate drugs for SARS-CoV-2 are detailed in refs (29−31).
T42 6328-6704 Sentence denotes In the past decade, there has been growing interest in novel, broad-spectrum antiviral compounds, which might be less prone to resistance and could be employed against a wide class of different viruses, including new variants.32−34 Importantly, such therapies could be prescribed until more sophisticated, targeted drugs and vaccines are available for each new emerging virus.
T43 6705-7676 Sentence denotes Nanotechnology offers a number of solutions to fight viruses, both outside and inside the host, and several nanotechnology-based platforms have already been successful in preclinical studies to counter several human viral pathogens such as HIV, human papilloma virus, herpes simplex, and respiratory viruses.32−35 Nanotechnology-based approaches should be leveraged to help the fight against COVID-19 as well as any future pandemics, in a number of ways, including (i) novel vaccines and drugs, where nanomaterials can be leveraged for direct delivery of broad-spectrum antivirals and to support targeted therapies to the lungs; (ii) highly specific, rapid, and sensitive tests to detect infection or to detect immunity (serological tests); (iii) superfine filters for face masks or blood filtering; (iv) novel surfaces or surface coatings that are resistant to viral adhesion and can inactivate the virus; and (v) the improvement of tools for contact tracing (Figure 2).
T44 7677-7740 Sentence denotes Figure 2 Nanomaterials for prevention and therapy of COVID-19.
T45 7741-7873 Sentence denotes Integrating nanomaterials into personal protective equipment (PPE) can prevent the entrance of SARS-CoV-2 in the respiratory system.
T46 7874-7963 Sentence denotes Nanomaterials could also be used to deliver drugs to the pulmonary system via inhalators.
T47 7964-8143 Sentence denotes Cellular binding of viral particles at the alveoli can be inhibited using targeted nanoparticles (NPs) against angiotensin-converting enzyme 2 (ACE2) receptors or viral S protein.
T48 8144-8281 Sentence denotes Various mechanisms can be used to inactivate viral particles systemically such as using neutralizing NPs or photocatalytic nanomaterials.
T49 8282-8428 Sentence denotes Nanomaterial-based vaccines or immunomodulation can be used to prevent SARS-CoV-2 infection or even to boost the immune response during infection.
T50 8429-8455 Sentence denotes PDT, photodynamic therapy.
T51 8456-8900 Sentence denotes This crisis has also highlighted the importance of rapid prototyping/manufacturing for addressing unforeseen needs, such as in case of a pandemic, where large-scale production of equipment including ventilators and personal protective equipment (PPE) is urgently needed and nanotechnology may aid (e.g., in providing readily synthesizable materials for equipment manufacturing as well as for the improvement of their efficiency and durability).
T52 8901-9049 Sentence denotes In the next sections, we expand and elaborate on the specific contributions that nanotechnology can offer to counter COVID-19 and similar pandemics.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
33 0-8 Disease denotes COVID-19 MESH:C000657245
35 957-963 Disease denotes cancer MESH:D009369
38 1150-1166 Disease denotes Viral infections MESH:D001102
39 1214-1223 Disease denotes mortality MESH:D003643
51 1605-1622 Species denotes novel coronavirus Tax:2697049
52 1703-1714 Species denotes Coronavirus Tax:11118
53 1813-1823 Species denotes SARS-CoV-2 Tax:2697049
54 1966-1976 Species denotes SARS-CoV-2 Tax:2697049
55 2102-2112 Species denotes SARS-CoV-2 Tax:2697049
56 1631-1640 Disease denotes pneumonia MESH:D011014
57 1978-2002 Disease denotes coronavirus disease 2019 MESH:C000657245
58 2005-2013 Disease denotes COVID-19 MESH:C000657245
59 2056-2064 Disease denotes COVID-19 MESH:C000657245
60 2181-2191 Disease denotes infections MESH:D007239
61 2221-2227 Disease denotes deaths MESH:D003643
83 2489-2497 Species denotes patients Tax:9606
84 2740-2748 Species denotes patients Tax:9606
85 2252-2260 Disease denotes COVID-19 MESH:C000657245
86 2265-2270 Disease denotes fever MESH:D005334
87 2280-2285 Disease denotes cough MESH:D003371
88 2299-2306 Disease denotes fatigue MESH:D005221
89 2351-2358 Disease denotes dyspnea MESH:D004417
90 2360-2368 Disease denotes headache MESH:D006261
91 2370-2386 Disease denotes loss of appetite MESH:D001068
92 2397-2408 Disease denotes sore throat MESH:D010608
93 2410-2418 Disease denotes vomiting MESH:D014839
94 2420-2428 Disease denotes diarrhea MESH:D003967
95 2430-2440 Disease denotes rhinorrhea MESH:D012818
96 2446-2460 Disease denotes abdominal pain MESH:D015746
97 2554-2566 Disease denotes hypertension MESH:D006973
98 2568-2576 Disease denotes diabetes MESH:D003920
99 2582-2604 Disease denotes coronary heart disease MESH:D003324
100 2731-2739 Disease denotes COVID-19 MESH:C000657245
101 2812-2826 Disease denotes conjunctivitis MESH:D003231
102 2840-2852 Disease denotes encephalitis MESH:D004660
103 2924-2932 Disease denotes COVID-19 MESH:C000657245
111 3357-3361 Gene denotes ACE2 Gene:59272
112 3030-3040 Species denotes SARS-CoV-2 Tax:2697049
113 3130-3143 Species denotes coronaviruses Tax:11118
114 3181-3189 Species denotes SARS-CoV Tax:694009
115 3232-3240 Species denotes SARS-CoV Tax:694009
116 3310-3315 Species denotes human Tax:9606
117 3152-3172 Disease denotes respiratory diseases MESH:D012140
128 3545-3549 Gene denotes ACE2 Gene:59272
129 3699-3703 Gene denotes ACE2 Gene:59272
130 3876-3880 Gene denotes ACE2 Gene:59272
131 3933-3937 Gene denotes ACE2 Gene:59272
132 4140-4144 Gene denotes ACE2 Gene:59272
133 4246-4250 Gene denotes ACE2 Gene:59272
134 4214-4215 Gene denotes S Gene:43740568
135 4111-4112 Gene denotes S Gene:43740568
136 3528-3538 Species denotes SARS-CoV-2 Tax:2697049
137 3739-3748 Disease denotes infection MESH:D007239
144 4465-4469 Gene denotes ACE2 Gene:59272
145 4546-4554 Species denotes patients Tax:9606
146 5032-5037 Species denotes human Tax:9606
147 4385-4394 Disease denotes infection MESH:D007239
148 4747-4756 Disease denotes infection MESH:D007239
149 4911-4933 Disease denotes multiple-organ failure MESH:D009102
156 5334-5365 Gene denotes angiotensin-converting enzyme 2 Gene:59272
157 5367-5371 Gene denotes ACE2 Gene:59272
158 5442-5449 Gene denotes TMPRSS2 Gene:7113
159 5245-5255 Species denotes SARS-CoV-2 Tax:2697049
160 5314-5324 Species denotes SARS-CoV-2 Tax:2697049
161 5423-5429 Chemical denotes serine MESH:D012694
165 6086-6096 Species denotes SARS-CoV-2 Tax:2697049
166 6287-6297 Species denotes SARS-CoV-2 Tax:2697049
167 6214-6230 Disease denotes viral infections MESH:D001102
173 6915-6920 Species denotes human Tax:9606
174 6950-6971 Species denotes human papilloma virus Tax:10566
175 6993-7004 Species denotes respiratory Tax:12814
176 7097-7105 Disease denotes COVID-19 MESH:C000657245
177 7393-7402 Disease denotes infection MESH:D007239
185 8075-8106 Gene denotes angiotensin-converting enzyme 2 Gene:59272
186 8108-8112 Gene denotes ACE2 Gene:59272
187 7836-7846 Species denotes SARS-CoV-2 Tax:2697049
188 7854-7865 Species denotes respiratory Tax:12814
189 7731-7739 Disease denotes COVID-19 MESH:C000657245
190 8358-8373 Disease denotes CoV-2 infection MESH:C000657245
191 8418-8427 Disease denotes infection MESH:D007239
193 9018-9026 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32519842-27449616-158444 285-286 27449616 denotes 1
32519842-11642817-158445 457-458 11642817 denotes 2
32519842-32341506-158446 459-460 32341506 denotes 4
32519842-25022906-158447 998-999 25022906 denotes 5
32519842-27874854-158448 1000-1001 27874854 denotes 6
32519842-23245604-158449 1294-1295 23245604 denotes 7
32519842-32123347-158450 1856-1858 32123347 denotes 10
32519842-31986264-158451 2608-2610 31986264 denotes 13
32519842-32150748-158452 2694-2696 32150748 denotes 14
32519842-32247212-158453 2854-2856 32247212 denotes 15
32519842-32015507-158454 3065-3067 32015507 denotes 19
32519842-32257431-158455 3190-3192 32257431 denotes 20
32519842-32015507-158456 3417-3419 32015507 denotes 19
32519842-32333836-158457 3420-3422 32333836 denotes 21
32519842-32142651-158458 3423-3425 32142651 denotes 23
32519842-32275855-158459 3660-3662 32275855 denotes 24
32519842-32333836-158460 4045-4047 32333836 denotes 21
32519842-32142651-158461 4336-4338 32142651 denotes 23
32519842-32325025-158462 4934-4936 32325025 denotes 25
32519842-32259480-158463 5905-5907 32259480 denotes 27
32519842-32194980-158464 6320-6322 32194980 denotes 29
32519842-27575283-158465 6554-6556 27575283 denotes 32
32519842-26551316-158466 6557-6559 26551316 denotes 34
32519842-27575283-158467 7013-7015 27575283 denotes 32