PMC:7299399 / 20232-21435
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7299399","sourcedb":"PMC","sourceid":"7299399","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7299399","text":"Another candidate COVID-19 vaccine for Phase I clinical trial is from the University of Oxford and AstraZeneca (NCT04324606).68 Around 1110 people will take part in the trial, which started recruitment at the end of April 2020. The vaccine is based on a chimpanzee adenovirus vaccine vector (ChAdOx1) and the SARS-CoV-2 spike protein. Chimpanzee adenoviral vectors against different pathogens have been already tested in thousands of subjects with demonstrated safety. To date, ChAdOx1 has been administered to six rhesus macaques exposed to high doses of SARS-CoV-2. The vaccine was unable to prevent infections, although it reduced the severity of the disease: no signs of virus replication were observed in the lungs, with significantly lower levels of respiratory disease and no lung damage compared to control animals, according to a recent article deposited in bioRxiv.69 Another adenoviral vector vaccine developed by CanSino Biological Inc. and Beijing Institute of Biotechnology using a genetically engineered replication-defective adenovirus type 5 vector to express the SARS-CoV-2 spike protein (Ad5-nCoV) is currently being tested in Phase I/II trials (NCT04398147, NCT04341389, NCT0431312).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T93","span":{"begin":326,"end":333},"obj":"Body_part"},{"id":"T94","span":{"begin":714,"end":719},"obj":"Body_part"},{"id":"T95","span":{"begin":783,"end":787},"obj":"Body_part"},{"id":"T96","span":{"begin":1098,"end":1105},"obj":"Body_part"}],"attributes":[{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T27","span":{"begin":783,"end":787},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":18,"end":26},"obj":"Disease"},{"id":"T73","span":{"begin":309,"end":317},"obj":"Disease"},{"id":"T74","span":{"begin":556,"end":564},"obj":"Disease"},{"id":"T75","span":{"begin":602,"end":612},"obj":"Disease"},{"id":"T76","span":{"begin":756,"end":775},"obj":"Disease"},{"id":"T77","span":{"begin":1081,"end":1089},"obj":"Disease"},{"id":"T78","span":{"begin":1107,"end":1110},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0011194"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T204","span":{"begin":252,"end":253},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T205","span":{"begin":254,"end":264},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9598"},{"id":"T206","span":{"begin":335,"end":345},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9598"},{"id":"T207","span":{"begin":411,"end":417},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T208","span":{"begin":486,"end":489},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T209","span":{"begin":515,"end":530},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9544"},{"id":"T210","span":{"begin":675,"end":680},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T211","span":{"begin":714,"end":719},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T212","span":{"begin":783,"end":787},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T213","span":{"begin":783,"end":787},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T214","span":{"begin":815,"end":822},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T215","span":{"begin":837,"end":838},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T216","span":{"begin":994,"end":995},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T217","span":{"begin":1136,"end":1142},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"attributes":[{"subj":"T204","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T210","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T132","span":{"begin":326,"end":333},"obj":"Chemical"},{"id":"T133","span":{"begin":1098,"end":1105},"obj":"Chemical"},{"id":"T134","span":{"begin":1154,"end":1156},"obj":"Chemical"}],"attributes":[{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T87","span":{"begin":0,"end":227},"obj":"Sentence"},{"id":"T88","span":{"begin":228,"end":334},"obj":"Sentence"},{"id":"T89","span":{"begin":335,"end":468},"obj":"Sentence"},{"id":"T90","span":{"begin":469,"end":567},"obj":"Sentence"},{"id":"T91","span":{"begin":568,"end":1203},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T87","pred":"source","obj":"LitCovid-sentences"},{"subj":"T88","pred":"source","obj":"LitCovid-sentences"},{"subj":"T89","pred":"source","obj":"LitCovid-sentences"},{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"308","span":{"begin":1107,"end":1110},"obj":"Gene"},{"id":"309","span":{"begin":1092,"end":1097},"obj":"Gene"},{"id":"310","span":{"begin":320,"end":325},"obj":"Gene"},{"id":"311","span":{"begin":1146,"end":1156},"obj":"Gene"},{"id":"312","span":{"begin":140,"end":146},"obj":"Species"},{"id":"313","span":{"begin":254,"end":275},"obj":"Species"},{"id":"314","span":{"begin":309,"end":319},"obj":"Species"},{"id":"315","span":{"begin":335,"end":345},"obj":"Species"},{"id":"316","span":{"begin":515,"end":530},"obj":"Species"},{"id":"317","span":{"begin":556,"end":566},"obj":"Species"},{"id":"318","span":{"begin":1041,"end":1058},"obj":"Species"},{"id":"319","span":{"begin":1081,"end":1091},"obj":"Species"},{"id":"320","span":{"begin":1111,"end":1115},"obj":"Species"},{"id":"321","span":{"begin":18,"end":26},"obj":"Disease"},{"id":"322","span":{"begin":602,"end":612},"obj":"Disease"},{"id":"323","span":{"begin":756,"end":775},"obj":"Disease"}],"attributes":[{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"Gene:8081"},{"id":"A309","pred":"tao:has_database_id","subj":"309","obj":"Gene:43740568"},{"id":"A310","pred":"tao:has_database_id","subj":"310","obj":"Gene:43740568"},{"id":"A312","pred":"tao:has_database_id","subj":"312","obj":"Tax:9606"},{"id":"A313","pred":"tao:has_database_id","subj":"313","obj":"Tax:310542"},{"id":"A314","pred":"tao:has_database_id","subj":"314","obj":"Tax:2697049"},{"id":"A315","pred":"tao:has_database_id","subj":"315","obj":"Tax:9598"},{"id":"A316","pred":"tao:has_database_id","subj":"316","obj":"Tax:9544"},{"id":"A317","pred":"tao:has_database_id","subj":"317","obj":"Tax:2697049"},{"id":"A318","pred":"tao:has_database_id","subj":"318","obj":"Tax:28285"},{"id":"A319","pred":"tao:has_database_id","subj":"319","obj":"Tax:2697049"},{"id":"A320","pred":"tao:has_database_id","subj":"320","obj":"Tax:2697049"},{"id":"A321","pred":"tao:has_database_id","subj":"321","obj":"MESH:C000657245"},{"id":"A322","pred":"tao:has_database_id","subj":"322","obj":"MESH:D007239"},{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"MESH:D012140"},{"subj":"308","pred":"source","obj":"LitCovid-PubTator"},{"subj":"309","pred":"source","obj":"LitCovid-PubTator"},{"subj":"310","pred":"source","obj":"LitCovid-PubTator"},{"subj":"311","pred":"source","obj":"LitCovid-PubTator"},{"subj":"312","pred":"source","obj":"LitCovid-PubTator"},{"subj":"313","pred":"source","obj":"LitCovid-PubTator"},{"subj":"314","pred":"source","obj":"LitCovid-PubTator"},{"subj":"315","pred":"source","obj":"LitCovid-PubTator"},{"subj":"316","pred":"source","obj":"LitCovid-PubTator"},{"subj":"317","pred":"source","obj":"LitCovid-PubTator"},{"subj":"318","pred":"source","obj":"LitCovid-PubTator"},{"subj":"319","pred":"source","obj":"LitCovid-PubTator"},{"subj":"320","pred":"source","obj":"LitCovid-PubTator"},{"subj":"321","pred":"source","obj":"LitCovid-PubTator"},{"subj":"322","pred":"source","obj":"LitCovid-PubTator"},{"subj":"323","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ec97","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93a8"},{"id":"LitCovid-PD-MONDO","color":"#93c2ec"},{"id":"LitCovid-PD-CLO","color":"#dcec93"},{"id":"LitCovid-PD-CHEBI","color":"#e293ec"},{"id":"LitCovid-sentences","color":"#93ecc8"},{"id":"LitCovid-PubTator","color":"#ecae93"}]}]}}