PMC:7299399 / 20232-21435
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T93 | 326-333 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T94 | 714-719 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T95 | 783-787 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T96 | 1098-1105 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T27 | 783-787 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T72 | 18-26 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T73 | 309-317 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T74 | 556-564 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T75 | 602-612 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T76 | 756-775 | Disease | denotes | respiratory disease | http://purl.obolibrary.org/obo/MONDO_0005087 |
| T77 | 1081-1089 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T78 | 1107-1110 | Disease | denotes | Ad5 | http://purl.obolibrary.org/obo/MONDO_0011194 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T204 | 252-253 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T205 | 254-264 | http://purl.obolibrary.org/obo/NCBITaxon_9598 | denotes | chimpanzee |
| T206 | 335-345 | http://purl.obolibrary.org/obo/NCBITaxon_9598 | denotes | Chimpanzee |
| T207 | 411-417 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T208 | 486-489 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T209 | 515-530 | http://purl.obolibrary.org/obo/NCBITaxon_9544 | denotes | rhesus macaques |
| T210 | 675-680 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T211 | 714-719 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T212 | 783-787 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T213 | 783-787 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T214 | 815-822 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T215 | 837-838 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T216 | 994-995 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T217 | 1136-1142 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T132 | 326-333 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T133 | 1098-1105 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T134 | 1154-1156 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T87 | 0-227 | Sentence | denotes | Another candidate COVID-19 vaccine for Phase I clinical trial is from the University of Oxford and AstraZeneca (NCT04324606).68 Around 1110 people will take part in the trial, which started recruitment at the end of April 2020. |
| T88 | 228-334 | Sentence | denotes | The vaccine is based on a chimpanzee adenovirus vaccine vector (ChAdOx1) and the SARS-CoV-2 spike protein. |
| T89 | 335-468 | Sentence | denotes | Chimpanzee adenoviral vectors against different pathogens have been already tested in thousands of subjects with demonstrated safety. |
| T90 | 469-567 | Sentence | denotes | To date, ChAdOx1 has been administered to six rhesus macaques exposed to high doses of SARS-CoV-2. |
| T91 | 568-1203 | Sentence | denotes | The vaccine was unable to prevent infections, although it reduced the severity of the disease: no signs of virus replication were observed in the lungs, with significantly lower levels of respiratory disease and no lung damage compared to control animals, according to a recent article deposited in bioRxiv.69 Another adenoviral vector vaccine developed by CanSino Biological Inc. and Beijing Institute of Biotechnology using a genetically engineered replication-defective adenovirus type 5 vector to express the SARS-CoV-2 spike protein (Ad5-nCoV) is currently being tested in Phase I/II trials (NCT04398147, NCT04341389, NCT0431312). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 308 | 1107-1110 | Gene | denotes | Ad5 | Gene:8081 |
| 309 | 1092-1097 | Gene | denotes | spike | Gene:43740568 |
| 310 | 320-325 | Gene | denotes | spike | Gene:43740568 |
| 311 | 1146-1156 | Gene | denotes | Phase I/II | |
| 312 | 140-146 | Species | denotes | people | Tax:9606 |
| 313 | 254-275 | Species | denotes | chimpanzee adenovirus | Tax:310542 |
| 314 | 309-319 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 315 | 335-345 | Species | denotes | Chimpanzee | Tax:9598 |
| 316 | 515-530 | Species | denotes | rhesus macaques | Tax:9544 |
| 317 | 556-566 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 318 | 1041-1058 | Species | denotes | adenovirus type 5 | Tax:28285 |
| 319 | 1081-1091 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 320 | 1111-1115 | Species | denotes | nCoV | Tax:2697049 |
| 321 | 18-26 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 322 | 602-612 | Disease | denotes | infections | MESH:D007239 |
| 323 | 756-775 | Disease | denotes | respiratory disease | MESH:D012140 |