PMC:7295558 / 12607-13862 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T112","span":{"begin":124,"end":131},"obj":"UBERON:0000948"},{"id":"T113","span":{"begin":162,"end":172},"obj":"UBERON:0002349"},{"id":"T114","span":{"begin":269,"end":279},"obj":"UBERON:0002349"},{"id":"T115","span":{"begin":334,"end":342},"obj":"SP_7"},{"id":"T116","span":{"begin":353,"end":363},"obj":"UBERON:0002349"},{"id":"T117","span":{"begin":442,"end":451},"obj":"UBERON:0003126"},{"id":"T118","span":{"begin":471,"end":480},"obj":"UBERON:0003126"},{"id":"T119","span":{"begin":517,"end":522},"obj":"UBERON:0000178"},{"id":"T120","span":{"begin":582,"end":590},"obj":"SP_10"},{"id":"T121","span":{"begin":695,"end":703},"obj":"SP_7"},{"id":"T122","span":{"begin":715,"end":727},"obj":"GO:0050817"},{"id":"T123","span":{"begin":833,"end":843},"obj":"GO:0007596"},{"id":"T124","span":{"begin":875,"end":883},"obj":"SP_7"},{"id":"T125","span":{"begin":892,"end":901},"obj":"UBERON:0002048"},{"id":"T126","span":{"begin":1045,"end":1054},"obj":"UBERON:0002048"},{"id":"T127","span":{"begin":1164,"end":1182},"obj":"GO:0007596"},{"id":"T128","span":{"begin":1216,"end":1224},"obj":"UBERON:0010210"},{"id":"T63600","span":{"begin":124,"end":131},"obj":"UBERON:0000948"},{"id":"T61077","span":{"begin":162,"end":172},"obj":"UBERON:0002349"},{"id":"T88255","span":{"begin":269,"end":279},"obj":"UBERON:0002349"},{"id":"T99292","span":{"begin":334,"end":342},"obj":"SP_7"},{"id":"T27430","span":{"begin":353,"end":363},"obj":"UBERON:0002349"},{"id":"T28250","span":{"begin":442,"end":451},"obj":"UBERON:0003126"},{"id":"T15014","span":{"begin":471,"end":480},"obj":"UBERON:0003126"},{"id":"T8599","span":{"begin":517,"end":522},"obj":"UBERON:0000178"},{"id":"T57055","span":{"begin":582,"end":590},"obj":"SP_10"},{"id":"T53160","span":{"begin":695,"end":703},"obj":"SP_7"},{"id":"T45664","span":{"begin":715,"end":727},"obj":"GO:0050817"},{"id":"T77693","span":{"begin":833,"end":843},"obj":"GO:0007596"},{"id":"T68410","span":{"begin":875,"end":883},"obj":"SP_7"},{"id":"T1894","span":{"begin":892,"end":901},"obj":"UBERON:0002048"},{"id":"T50114","span":{"begin":1045,"end":1054},"obj":"UBERON:0002048"},{"id":"T22379","span":{"begin":1164,"end":1182},"obj":"GO:0007596"},{"id":"T60869","span":{"begin":1216,"end":1224},"obj":"UBERON:0010210"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T32","span":{"begin":39,"end":48},"obj":"Body_part"},{"id":"T33","span":{"begin":517,"end":522},"obj":"Body_part"}],"attributes":[{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma62338"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma9670"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":517,"end":522},"obj":"Body_part"},{"id":"T17","span":{"begin":1241,"end":1246},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0003978"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":148,"end":150},"obj":"Disease"},{"id":"T75","span":{"begin":152,"end":154},"obj":"Disease"},{"id":"T76","span":{"begin":334,"end":342},"obj":"Disease"},{"id":"T77","span":{"begin":471,"end":494},"obj":"Disease"},{"id":"T78","span":{"begin":582,"end":600},"obj":"Disease"},{"id":"T79","span":{"begin":591,"end":600},"obj":"Disease"},{"id":"T80","span":{"begin":622,"end":634},"obj":"Disease"},{"id":"T81","span":{"begin":695,"end":703},"obj":"Disease"},{"id":"T82","span":{"begin":715,"end":727},"obj":"Disease"},{"id":"T83","span":{"begin":729,"end":732},"obj":"Disease"},{"id":"T84","span":{"begin":751,"end":769},"obj":"Disease"},{"id":"T85","span":{"begin":875,"end":883},"obj":"Disease"},{"id":"T86","span":{"begin":892,"end":910},"obj":"Disease"},{"id":"T87","span":{"begin":1216,"end":1224},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0017941"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0017941"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0002870"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0005025"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0002305"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005279"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T134","span":{"begin":155,"end":157},"obj":"http://purl.obolibrary.org/obo/PR_000010213"},{"id":"T135","span":{"begin":308,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T136","span":{"begin":440,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T137","span":{"begin":517,"end":522},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T138","span":{"begin":517,"end":522},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T139","span":{"begin":693,"end":694},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T140","span":{"begin":770,"end":773},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T141","span":{"begin":819,"end":820},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T142","span":{"begin":947,"end":948},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T143","span":{"begin":1214,"end":1215},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T144","span":{"begin":1241,"end":1246},"obj":"http://www.ebi.ac.uk/efo/EFO_0000825"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":152,"end":157},"obj":"http://purl.obolibrary.org/obo/GO_0004111"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-sentences","denotations":[{"id":"T145","span":{"begin":0,"end":212},"obj":"Sentence"},{"id":"T146","span":{"begin":213,"end":257},"obj":"Sentence"},{"id":"T147","span":{"begin":258,"end":415},"obj":"Sentence"},{"id":"T148","span":{"begin":416,"end":532},"obj":"Sentence"},{"id":"T149","span":{"begin":533,"end":666},"obj":"Sentence"},{"id":"T150","span":{"begin":667,"end":920},"obj":"Sentence"},{"id":"T151","span":{"begin":921,"end":1119},"obj":"Sentence"},{"id":"T152","span":{"begin":1120,"end":1255},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T50","span":{"begin":471,"end":494},"obj":"Phenotype"},{"id":"T51","span":{"begin":622,"end":634},"obj":"Phenotype"},{"id":"T52","span":{"begin":715,"end":727},"obj":"Phenotype"},{"id":"T53","span":{"begin":729,"end":732},"obj":"Phenotype"},{"id":"T54","span":{"begin":751,"end":769},"obj":"Phenotype"},{"id":"T55","span":{"begin":892,"end":910},"obj":"Phenotype"}],"attributes":[{"id":"A50","pred":"hp_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/HP_0005180"},{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0100584"},{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A53","pred":"hp_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A54","pred":"hp_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/HP_0100724"},{"id":"A55","pred":"hp_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/HP_0002204"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"LitCovid-PubTator","denotations":[{"id":"248","span":{"begin":148,"end":150},"obj":"Gene"},{"id":"249","span":{"begin":225,"end":233},"obj":"Species"},{"id":"250","span":{"begin":401,"end":409},"obj":"Species"},{"id":"251","span":{"begin":427,"end":435},"obj":"Species"},{"id":"252","span":{"begin":162,"end":184},"obj":"Disease"},{"id":"253","span":{"begin":253,"end":256},"obj":"Disease"},{"id":"254","span":{"begin":269,"end":291},"obj":"Disease"},{"id":"255","span":{"begin":334,"end":342},"obj":"Disease"},{"id":"256","span":{"begin":353,"end":377},"obj":"Disease"},{"id":"257","span":{"begin":386,"end":400},"obj":"Disease"},{"id":"258","span":{"begin":471,"end":494},"obj":"Disease"},{"id":"259","span":{"begin":582,"end":600},"obj":"Disease"},{"id":"260","span":{"begin":622,"end":634},"obj":"Disease"},{"id":"261","span":{"begin":695,"end":703},"obj":"Disease"},{"id":"262","span":{"begin":715,"end":727},"obj":"Disease"},{"id":"263","span":{"begin":751,"end":769},"obj":"Disease"},{"id":"264","span":{"begin":833,"end":843},"obj":"Disease"},{"id":"265","span":{"begin":875,"end":883},"obj":"Disease"},{"id":"266","span":{"begin":892,"end":910},"obj":"Disease"},{"id":"267","span":{"begin":1216,"end":1224},"obj":"Disease"}],"attributes":[{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"Gene:51727"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"Tax:9606"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"Tax:9606"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Tax:9606"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"MESH:D009202"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"MESH:D002318"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D009202"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:C000657245"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"MESH:D009202"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"MESH:D016638"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"MESH:D014262"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"MESH:C000657245"},{"id":"A260","pred":"tao:has_database_id","subj":"260","obj":"MESH:D004696"},{"id":"A261","pred":"tao:has_database_id","subj":"261","obj":"MESH:C000657245"},{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"MESH:D001778"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"MESH:D019851"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"MESH:D013927"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"MESH:C000657245"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"MESH:D011655"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"MESH:D013927"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}

{"project":"2_test","denotations":[{"id":"32595812-30521759-18405867","span":{"begin":411,"end":413},"obj":"30521759"},{"id":"32595812-14736283-18405868","span":{"begin":662,"end":664},"obj":"14736283"},{"id":"32595812-32302453-18405869","span":{"begin":916,"end":918},"obj":"32302453"}],"text":"In this series, serial measurements of troponins or D-dimer determination were not available, but increased levels of other cardiac markers such as CK, CK-MB and myocardial dysfunction detected by TTE were found. None of our patients had previous known CVD. Therefore, myocardial dysfunction could represent a direct manifestation of COVID-19, and also myocardial abnormalities seen in critically ill patients [13]. One of our patients had a tricuspid vegetation, severe tricuspid regurgitation and repeated negative blood cultures. Interestingly, previous reports in subjects with SARS-CoV infection show the presence of endocarditis with marantic vegetations [14]. Recently, the presence of a COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability has been proposed, and recent studies have found a presence of thrombotic events in 31% of subjects with COVID-19, mainly pulmonary embolism [15, 16]. We were unable to perform a pathologic evaluation of our subject’s vegetation for this report, and computed tomography (CT)-pulmonary angiography was not available because of his clinical condition. Although all of our subjects were receiving thromboprophylaxis, the possibility of this being a thrombus attached to the valve remains."}