PMC:7294857 / 26988-28368 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7294857","sourcedb":"PMC","sourceid":"7294857","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7294857","text":"Convalescent plasma and passive immunization: Convalescent plasma has already been in use for some diseases; it was also effective in MERS-CoV infection. Its safety and efficacy were tested by Arabi et al. and showed that it could be used as a potential treatment option in COVID-19 [27]. The WHO recently recommended its use as passive immunization in all serious patients because of the unavailability of active immunization in the form of vaccines [27].The plasma of recovered patients was used in different patients and had shown positive effects. A case review series by Shen et al. discussed five critically ill patients having COVID-19 with ARDS who were given antibody-rich convalescent plasma. They showed significant improvement in clinical status, their SOFA score improved, temperature improved, and they also were weaned off from a ventilator [28]. The results, however, cannot be considered as significantly reliable because of the small sample size. Another case study showed significant improvement in symptoms and a decrease in viremia and viral load in seven out of 10 patients without any serious side effects [29]. Despite the positive results and considering that most of the studies had weak evidence, it can help manage patients. Still, more studies are needed to assess its potential serious side-effects like transfusion-related acute lung injury 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