PMC:7293470 / 5518-6113 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7293470","sourcedb":"PMC","sourceid":"7293470","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7293470","text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. 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