PMC:7293470 / 5518-6113 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T168","span":{"begin":73,"end":83},"obj":"SP_7"},{"id":"T169","span":{"begin":108,"end":112},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T170","span":{"begin":130,"end":133},"obj":"PR:000029150"},{"id":"T171","span":{"begin":139,"end":145},"obj":"SO:0000417"},{"id":"T172","span":{"begin":146,"end":163},"obj":"MOP:0000779"},{"id":"T173","span":{"begin":167,"end":172},"obj":"SP_6;NCBITaxon:9606"},{"id":"T174","span":{"begin":173,"end":179},"obj":"UBERON:0000345"},{"id":"T175","span":{"begin":180,"end":201},"obj":"CL:0000128"},{"id":"T176","span":{"begin":202,"end":214},"obj":"CHEBI:17089;CHEBI:17089;PR:000037069;BV_11"},{"id":"T177","span":{"begin":216,"end":219},"obj":"PR:000010514"},{"id":"T178","span":{"begin":296,"end":302},"obj":"CL:0000084"},{"id":"T179","span":{"begin":321,"end":324},"obj":"GO:0042611"},{"id":"T180","span":{"begin":344,"end":348},"obj":"PR:000001822"},{"id":"T181","span":{"begin":402,"end":410},"obj":"SO:0000853"},{"id":"T182","span":{"begin":420,"end":424},"obj":"PR:P11914"},{"id":"T183","span":{"begin":525,"end":531},"obj":"SO:0000417"},{"id":"T35466","span":{"begin":73,"end":83},"obj":"SP_7"},{"id":"T93107","span":{"begin":108,"end":112},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T51669","span":{"begin":130,"end":133},"obj":"PR:000029150"},{"id":"T21336","span":{"begin":139,"end":145},"obj":"SO:0000417"},{"id":"T8587","span":{"begin":146,"end":163},"obj":"MOP:0000779"},{"id":"T89061","span":{"begin":167,"end":172},"obj":"SP_6;NCBITaxon:9606"},{"id":"T84719","span":{"begin":173,"end":179},"obj":"UBERON:0000345"},{"id":"T35539","span":{"begin":180,"end":201},"obj":"CL:0000128"},{"id":"T48954","span":{"begin":202,"end":214},"obj":"CHEBI:17089;CHEBI:17089;PR:000037069;BV_11"},{"id":"T10720","span":{"begin":216,"end":219},"obj":"PR:000010514"},{"id":"T14874","span":{"begin":296,"end":302},"obj":"CL:0000084"},{"id":"T62496","span":{"begin":321,"end":324},"obj":"GO:0042611"},{"id":"T5107","span":{"begin":344,"end":348},"obj":"PR:000001822"},{"id":"T21593","span":{"begin":402,"end":410},"obj":"SO:0000853"},{"id":"T530","span":{"begin":420,"end":424},"obj":"PR:P11914"},{"id":"T28730","span":{"begin":525,"end":531},"obj":"SO:0000417"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T67","span":{"begin":46,"end":54},"obj":"Body_part"},{"id":"T68","span":{"begin":130,"end":133},"obj":"Body_part"},{"id":"T69","span":{"begin":173,"end":179},"obj":"Body_part"},{"id":"T70","span":{"begin":180,"end":201},"obj":"Body_part"},{"id":"T71","span":{"begin":197,"end":201},"obj":"Body_part"},{"id":"T72","span":{"begin":202,"end":214},"obj":"Body_part"},{"id":"T73","span":{"begin":298,"end":302},"obj":"Body_part"},{"id":"T74","span":{"begin":321,"end":324},"obj":"Body_part"},{"id":"T75","span":{"begin":480,"end":488},"obj":"Body_part"}],"attributes":[{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma62977"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma54540"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T19","span":{"begin":173,"end":179},"obj":"Body_part"},{"id":"T20","span":{"begin":585,"end":594},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0000345"},{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T38","span":{"begin":73,"end":81},"obj":"Disease"},{"id":"T39","span":{"begin":73,"end":77},"obj":"Disease"}],"attributes":[{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T87","span":{"begin":5,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T88","span":{"begin":93,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T89","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T90","span":{"begin":197,"end":201},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T91","span":{"begin":221,"end":223},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T92","span":{"begin":227,"end":234},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T93","span":{"begin":296,"end":302},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T94","span":{"begin":571,"end":573},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T95","span":{"begin":577,"end":584},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T89","span":{"begin":108,"end":112},"obj":"Chemical"},{"id":"T90","span":{"begin":134,"end":136},"obj":"Chemical"},{"id":"T91","span":{"begin":202,"end":214},"obj":"Chemical"},{"id":"T92","span":{"begin":227,"end":234},"obj":"Chemical"},{"id":"T93","span":{"begin":516,"end":518},"obj":"Chemical"},{"id":"T94","span":{"begin":577,"end":584},"obj":"Chemical"}],"attributes":[{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T14","span":{"begin":46,"end":60},"obj":"Phenotype"},{"id":"T15","span":{"begin":480,"end":494},"obj":"Phenotype"}],"attributes":[{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T4","span":{"begin":567,"end":573},"obj":"GlycoEpitope"}],"attributes":[{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/AN0706"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-sentences","denotations":[{"id":"T26","span":{"begin":85,"end":235},"obj":"Sentence"},{"id":"T27","span":{"begin":236,"end":495},"obj":"Sentence"},{"id":"T28","span":{"begin":496,"end":507},"obj":"Sentence"},{"id":"T29","span":{"begin":508,"end":595},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}

{"project":"LitCovid-PubTator","denotations":[{"id":"153","span":{"begin":173,"end":214},"obj":"Gene"},{"id":"154","span":{"begin":216,"end":219},"obj":"Gene"},{"id":"155","span":{"begin":321,"end":324},"obj":"Gene"},{"id":"156","span":{"begin":412,"end":415},"obj":"Gene"},{"id":"157","span":{"begin":420,"end":424},"obj":"Gene"},{"id":"158","span":{"begin":567,"end":570},"obj":"Gene"},{"id":"159","span":{"begin":73,"end":83},"obj":"Species"},{"id":"160","span":{"begin":167,"end":172},"obj":"Species"},{"id":"161","span":{"begin":85,"end":89},"obj":"Chemical"}],"attributes":[{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Gene:4340"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Gene:4340"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Gene:3107"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:4282"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Gene:1060"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"Gene:4340"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"Tax:2697049"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Dual activities of DRhQ that could block the “Cytokine Storm” induced by SARS-CoV-2. DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. DRhQ image: Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension."}