PMC:7291971 / 85505-86967 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"The transfer of tritiated methyl from [3H] SAM onto RNA substrate was monitored by filter binding assay, performed according to the method described previously [40]. Assays were carried out in reaction mixture [40 mM Tris-HCl (pH 8.0), 1 mM DTT, 1 mM MgCl2, 2 μM SAM and 0.1 μM 3H-SAM (PerkinElmer)] in the presence of 0.7 μM GpppAC4 synthetic RNA and SARS-CoV nsp14 (50 nM), vaccinia virus capping enzyme (D1-D12) (41 U), or human RNA N7 MTase (hRNMT) (50 nM). The enzymes were first mixed with compounds suspended in 100% DMSO (5% final DMSO) before the addition of RNA substrate and SAM and then incubated at 30 °C. Control reactions were performed in the presence of 5% DMSO. Reactions mixtures were stopped after 30 min by their 10-fold dilution in ice-cold water. Samples were transferred to diethylaminoethyl (DEAE) filtermat (PerkinElmer) using a Filtermat Harvester (Packard Instruments). The RNA-retaining mats were washed twice with 10 mM ammonium formate pH 8.0, twice with water and once with ethanol. They were soaked with scintillation fluid (PerkinElmer), and 3H-methyl transfer to the RNA substrates was determined using a Wallac MicroBeta TriLux Liquid Scintillation Counter (PerkinElmer). For IC50 measurements, values were normalized and fitted with Prism (GraphPad software) using the following equation: Y = 100/(1+((X/IC50)^Hillslope)). IC50 is defined as the inhibitory compound concentration that causes 50% reduction in enzyme activity.","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1693","span":{"begin":39,"end":41},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T1694","span":{"begin":202,"end":209},"obj":"CHEBI:60004;CHEBI:60004"},{"id":"T1695","span":{"begin":217,"end":221},"obj":"CHEBI:9754;CHEBI:9754"},{"id":"T1696","span":{"begin":222,"end":225},"obj":"CHEBI:17883;CHEBI:17883"},{"id":"T1697","span":{"begin":241,"end":244},"obj":"CHEBI:18320;CHEBI:18320"},{"id":"T1698","span":{"begin":251,"end":256},"obj":"CHEBI:6636;CHEBI:6636"},{"id":"T1699","span":{"begin":278,"end":280},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T1700","span":{"begin":352,"end":360},"obj":"SP_10"},{"id":"T1701","span":{"begin":361,"end":366},"obj":"PR:000000125"},{"id":"T1702","span":{"begin":376,"end":384},"obj":"NCBITaxon:7742"},{"id":"T1703","span":{"begin":385,"end":390},"obj":"NCBITaxon:10239"},{"id":"T1704","span":{"begin":426,"end":431},"obj":"SP_6;NCBITaxon:9606"},{"id":"T1705","span":{"begin":446,"end":451},"obj":"PR:O43148"},{"id":"T1706","span":{"begin":496,"end":505},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T1707","span":{"begin":524,"end":528},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T1708","span":{"begin":539,"end":543},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T1709","span":{"begin":674,"end":678},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T1710","span":{"begin":690,"end":698},"obj":"CHEBI:60004;CHEBI:60004"},{"id":"T1711","span":{"begin":763,"end":768},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T1712","span":{"begin":798,"end":815},"obj":"CHEBI:35702;CHEBI:35702"},{"id":"T1713","span":{"begin":950,"end":966},"obj":"CHEBI:63050;CHEBI:63050"},{"id":"T1714","span":{"begin":986,"end":991},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T1715","span":{"begin":1006,"end":1013},"obj":"CHEBI:16236;CHEBI:16236"},{"id":"T1716","span":{"begin":1076,"end":1078},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T1717","span":{"begin":1394,"end":1402},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T18522","span":{"begin":39,"end":41},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T89446","span":{"begin":202,"end":209},"obj":"CHEBI:60004;CHEBI:60004"},{"id":"T7568","span":{"begin":217,"end":221},"obj":"CHEBI:9754;CHEBI:9754"},{"id":"T90528","span":{"begin":222,"end":225},"obj":"CHEBI:17883;CHEBI:17883"},{"id":"T32618","span":{"begin":241,"end":244},"obj":"CHEBI:18320;CHEBI:18320"},{"id":"T80620","span":{"begin":251,"end":256},"obj":"CHEBI:6636;CHEBI:6636"},{"id":"T65164","span":{"begin":278,"end":280},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T99852","span":{"begin":352,"end":360},"obj":"SP_10"},{"id":"T89465","span":{"begin":361,"end":366},"obj":"PR:000000125"},{"id":"T92733","span":{"begin":376,"end":384},"obj":"NCBITaxon:7742"},{"id":"T32742","span":{"begin":385,"end":390},"obj":"NCBITaxon:10239"},{"id":"T40449","span":{"begin":426,"end":431},"obj":"SP_6;NCBITaxon:9606"},{"id":"T9798","span":{"begin":446,"end":451},"obj":"PR:O43148"},{"id":"T22704","span":{"begin":496,"end":505},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T3161","span":{"begin":524,"end":528},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T66008","span":{"begin":539,"end":543},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T46228","span":{"begin":674,"end":678},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T24685","span":{"begin":690,"end":698},"obj":"CHEBI:60004;CHEBI:60004"},{"id":"T53961","span":{"begin":763,"end":768},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T66324","span":{"begin":798,"end":815},"obj":"CHEBI:35702;CHEBI:35702"},{"id":"T70177","span":{"begin":950,"end":966},"obj":"CHEBI:63050;CHEBI:63050"},{"id":"T31019","span":{"begin":986,"end":991},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T60694","span":{"begin":1006,"end":1013},"obj":"CHEBI:16236;CHEBI:16236"},{"id":"T18203","span":{"begin":1076,"end":1078},"obj":"CHEBI:29238;CHEBI:29238"},{"id":"T42093","span":{"begin":1394,"end":1402},"obj":"CHEBI:36357;CHEBI:36357"}],"attributes":[{"subj":"T1693","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1694","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1695","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1696","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1697","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1698","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1699","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1700","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1701","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1702","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1703","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1704","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1705","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1706","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1707","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1708","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1709","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1710","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1711","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1712","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1713","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1714","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1715","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1716","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1717","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18522","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89446","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7568","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90528","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32618","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80620","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65164","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T99852","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89465","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92733","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32742","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40449","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9798","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T22704","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T3161","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66008","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T46228","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24685","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T53961","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T66324","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70177","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31019","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T60694","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18203","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T42093","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T107","span":{"begin":52,"end":55},"obj":"Body_part"},{"id":"T108","span":{"begin":344,"end":347},"obj":"Body_part"},{"id":"T109","span":{"begin":432,"end":435},"obj":"Body_part"},{"id":"T110","span":{"begin":568,"end":571},"obj":"Body_part"},{"id":"T111","span":{"begin":902,"end":905},"obj":"Body_part"},{"id":"T112","span":{"begin":1086,"end":1105},"obj":"Body_part"},{"id":"T113","span":{"begin":1102,"end":1105},"obj":"Body_part"}],"attributes":[{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma67127"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1618","span":{"begin":39,"end":41},"obj":"Chemical"},{"id":"1619","span":{"begin":217,"end":221},"obj":"Chemical"},{"id":"1620","span":{"begin":222,"end":225},"obj":"Chemical"},{"id":"1621","span":{"begin":241,"end":244},"obj":"Chemical"},{"id":"1622","span":{"begin":251,"end":256},"obj":"Chemical"},{"id":"1623","span":{"begin":278,"end":280},"obj":"Chemical"},{"id":"1624","span":{"begin":524,"end":528},"obj":"Chemical"},{"id":"1625","span":{"begin":539,"end":543},"obj":"Chemical"},{"id":"1626","span":{"begin":674,"end":678},"obj":"Chemical"},{"id":"1627","span":{"begin":763,"end":768},"obj":"Chemical"},{"id":"1628","span":{"begin":798,"end":815},"obj":"Chemical"},{"id":"1629","span":{"begin":817,"end":821},"obj":"Chemical"},{"id":"1630","span":{"begin":950,"end":966},"obj":"Chemical"},{"id":"1631","span":{"begin":986,"end":991},"obj":"Chemical"},{"id":"1632","span":{"begin":1006,"end":1013},"obj":"Chemical"},{"id":"1633","span":{"begin":1076,"end":1078},"obj":"Chemical"}],"attributes":[{"id":"A1618","pred":"tao:has_database_id","subj":"1618","obj":"MESH:D014316"},{"id":"A1620","pred":"tao:has_database_id","subj":"1620","obj":"MESH:D006851"},{"id":"A1621","pred":"tao:has_database_id","subj":"1621","obj":"MESH:D004229"},{"id":"A1622","pred":"tao:has_database_id","subj":"1622","obj":"MESH:D015636"},{"id":"A1623","pred":"tao:has_database_id","subj":"1623","obj":"MESH:D014316"},{"id":"A1624","pred":"tao:has_database_id","subj":"1624","obj":"MESH:D004121"},{"id":"A1625","pred":"tao:has_database_id","subj":"1625","obj":"MESH:D004121"},{"id":"A1626","pred":"tao:has_database_id","subj":"1626","obj":"MESH:D004121"},{"id":"A1627","pred":"tao:has_database_id","subj":"1627","obj":"MESH:D014867"},{"id":"A1630","pred":"tao:has_database_id","subj":"1630","obj":"MESH:C030544"},{"id":"A1631","pred":"tao:has_database_id","subj":"1631","obj":"MESH:D014867"},{"id":"A1632","pred":"tao:has_database_id","subj":"1632","obj":"MESH:D000431"},{"id":"A1633","pred":"tao:has_database_id","subj":"1633","obj":"MESH:D014316"},{"subj":"1618","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1619","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1620","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1621","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1622","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1623","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1624","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1625","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1626","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1627","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1628","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1629","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1630","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1631","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1632","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1633","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T102","span":{"begin":352,"end":360},"obj":"Disease"},{"id":"T103","span":{"begin":376,"end":384},"obj":"Disease"}],"attributes":[{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0002595"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T445","span":{"begin":385,"end":390},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T446","span":{"begin":416,"end":418},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T447","span":{"begin":426,"end":431},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T448","span":{"begin":853,"end":854},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T449","span":{"begin":884,"end":895},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T450","span":{"begin":1138,"end":1139},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T451","span":{"begin":1453,"end":1461},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T445","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T950","span":{"begin":26,"end":32},"obj":"Chemical"},{"id":"T952","span":{"begin":43,"end":46},"obj":"Chemical"},{"id":"T954","span":{"begin":202,"end":209},"obj":"Chemical"},{"id":"T955","span":{"begin":217,"end":221},"obj":"Chemical"},{"id":"T956","span":{"begin":222,"end":225},"obj":"Chemical"},{"id":"T957","span":{"begin":241,"end":244},"obj":"Chemical"},{"id":"T958","span":{"begin":251,"end":256},"obj":"Chemical"},{"id":"T959","span":{"begin":263,"end":266},"obj":"Chemical"},{"id":"T961","span":{"begin":281,"end":284},"obj":"Chemical"},{"id":"T963","span":{"begin":524,"end":528},"obj":"Chemical"},{"id":"T964","span":{"begin":539,"end":543},"obj":"Chemical"},{"id":"T965","span":{"begin":586,"end":589},"obj":"Chemical"},{"id":"T967","span":{"begin":674,"end":678},"obj":"Chemical"},{"id":"T968","span":{"begin":763,"end":768},"obj":"Chemical"},{"id":"T969","span":{"begin":817,"end":821},"obj":"Chemical"},{"id":"T970","span":{"begin":950,"end":966},"obj":"Chemical"},{"id":"T971","span":{"begin":950,"end":958},"obj":"Chemical"},{"id":"T972","span":{"begin":959,"end":966},"obj":"Chemical"},{"id":"T974","span":{"begin":986,"end":991},"obj":"Chemical"},{"id":"T975","span":{"begin":1006,"end":1013},"obj":"Chemical"},{"id":"T976","span":{"begin":1079,"end":1085},"obj":"Chemical"},{"id":"T978","span":{"begin":1185,"end":1192},"obj":"Chemical"}],"attributes":[{"id":"A950","pred":"chebi_id","subj":"T950","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A951","pred":"chebi_id","subj":"T950","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A952","pred":"chebi_id","subj":"T952","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A953","pred":"chebi_id","subj":"T952","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A954","pred":"chebi_id","subj":"T954","obj":"http://purl.obolibrary.org/obo/CHEBI_60004"},{"id":"A955","pred":"chebi_id","subj":"T955","obj":"http://purl.obolibrary.org/obo/CHEBI_9754"},{"id":"A956","pred":"chebi_id","subj":"T956","obj":"http://purl.obolibrary.org/obo/CHEBI_17883"},{"id":"A957","pred":"chebi_id","subj":"T957","obj":"http://purl.obolibrary.org/obo/CHEBI_18320"},{"id":"A958","pred":"chebi_id","subj":"T958","obj":"http://purl.obolibrary.org/obo/CHEBI_6636"},{"id":"A959","pred":"chebi_id","subj":"T959","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A960","pred":"chebi_id","subj":"T959","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A961","pred":"chebi_id","subj":"T961","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A962","pred":"chebi_id","subj":"T961","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A963","pred":"chebi_id","subj":"T963","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A964","pred":"chebi_id","subj":"T964","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A965","pred":"chebi_id","subj":"T965","obj":"http://purl.obolibrary.org/obo/CHEBI_15414"},{"id":"A966","pred":"chebi_id","subj":"T965","obj":"http://purl.obolibrary.org/obo/CHEBI_67040"},{"id":"A967","pred":"chebi_id","subj":"T967","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A968","pred":"chebi_id","subj":"T968","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A969","pred":"chebi_id","subj":"T969","obj":"http://purl.obolibrary.org/obo/CHEBI_52153"},{"id":"A970","pred":"chebi_id","subj":"T970","obj":"http://purl.obolibrary.org/obo/CHEBI_63050"},{"id":"A971","pred":"chebi_id","subj":"T971","obj":"http://purl.obolibrary.org/obo/CHEBI_28938"},{"id":"A972","pred":"chebi_id","subj":"T972","obj":"http://purl.obolibrary.org/obo/CHEBI_15740"},{"id":"A973","pred":"chebi_id","subj":"T972","obj":"http://purl.obolibrary.org/obo/CHEBI_52343"},{"id":"A974","pred":"chebi_id","subj":"T974","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A975","pred":"chebi_id","subj":"T975","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A976","pred":"chebi_id","subj":"T976","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A977","pred":"chebi_id","subj":"T976","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A978","pred":"chebi_id","subj":"T978","obj":"http://purl.obolibrary.org/obo/CHEBI_38960"},{"subj":"T950","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T952","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T954","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T955","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T956","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T957","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T958","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T959","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T961","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T963","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T964","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T965","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T967","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T968","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T969","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T970","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T971","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T972","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T974","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T975","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T976","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T978","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T51","span":{"begin":1086,"end":1105},"obj":"http://purl.obolibrary.org/obo/GO_0030533"}],"attributes":[{"subj":"T51","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T563","span":{"begin":0,"end":165},"obj":"Sentence"},{"id":"T564","span":{"begin":166,"end":461},"obj":"Sentence"},{"id":"T565","span":{"begin":462,"end":618},"obj":"Sentence"},{"id":"T566","span":{"begin":619,"end":679},"obj":"Sentence"},{"id":"T567","span":{"begin":680,"end":769},"obj":"Sentence"},{"id":"T568","span":{"begin":770,"end":897},"obj":"Sentence"},{"id":"T569","span":{"begin":898,"end":1014},"obj":"Sentence"},{"id":"T570","span":{"begin":1015,"end":1207},"obj":"Sentence"},{"id":"T571","span":{"begin":1208,"end":1359},"obj":"Sentence"},{"id":"T572","span":{"begin":1360,"end":1462},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T563","pred":"source","obj":"LitCovid-sentences"},{"subj":"T564","pred":"source","obj":"LitCovid-sentences"},{"subj":"T565","pred":"source","obj":"LitCovid-sentences"},{"subj":"T566","pred":"source","obj":"LitCovid-sentences"},{"subj":"T567","pred":"source","obj":"LitCovid-sentences"},{"subj":"T568","pred":"source","obj":"LitCovid-sentences"},{"subj":"T569","pred":"source","obj":"LitCovid-sentences"},{"subj":"T570","pred":"source","obj":"LitCovid-sentences"},{"subj":"T571","pred":"source","obj":"LitCovid-sentences"},{"subj":"T572","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#dc93ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecc2"},{"id":"LitCovid-PubTator","color":"#eca893"},{"id":"LitCovid-PD-MONDO","color":"#9398ec"},{"id":"LitCovid-PD-CLO","color":"#b2ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93cc"},{"id":"LitCovid-PD-GO-BP","color":"#93e6ec"},{"id":"LitCovid-sentences","color":"#ecd893"}]}]}}