PMC:7291971 / 788-1321 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"rate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. The ","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T14","span":{"begin":5,"end":15},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":81,"end":84},"obj":"GO:0008541"},{"id":"T16","span":{"begin":107,"end":112},"obj":"NCBITaxon:10239"},{"id":"T17","span":{"begin":200,"end":210},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T18","span":{"begin":295,"end":304},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T19","span":{"begin":355,"end":367},"obj":"NCBITaxon:31032"},{"id":"T20","span":{"begin":371,"end":379},"obj":"SP_10"},{"id":"T21","span":{"begin":461,"end":469},"obj":"SP_10"},{"id":"T50627","span":{"begin":5,"end":15},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":81,"end":84},"obj":"GO:0008541"},{"id":"T87174","span":{"begin":107,"end":112},"obj":"NCBITaxon:10239"},{"id":"T40194","span":{"begin":200,"end":210},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T7397","span":{"begin":295,"end":304},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T53306","span":{"begin":355,"end":367},"obj":"NCBITaxon:31032"},{"id":"T48802","span":{"begin":371,"end":379},"obj":"SP_10"},{"id":"T86425","span":{"begin":461,"end":469},"obj":"SP_10"}],"attributes":[{"subj":"T14","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50627","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T65425","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T87174","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40194","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7397","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T53306","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48802","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86425","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":85,"end":88},"obj":"Body_part"},{"id":"T7","span":{"begin":168,"end":175},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82774"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":168,"end":189},"obj":"Chemical"},{"id":"11","span":{"begin":200,"end":210},"obj":"Chemical"},{"id":"12","span":{"begin":232,"end":240},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D000241"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:D009584"},{"subj":"10","pred":"source","obj":"LitCovid-PubTator"},{"subj":"11","pred":"source","obj":"LitCovid-PubTator"},{"subj":"12","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":371,"end":379},"obj":"Disease"},{"id":"T5","span":{"begin":461,"end":469},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":317,"end":323},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":5,"end":15},"obj":"Chemical"},{"id":"T10","span":{"begin":168,"end":175},"obj":"Chemical"},{"id":"T11","span":{"begin":200,"end":210},"obj":"Chemical"},{"id":"T12","span":{"begin":232,"end":240},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":62,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T3","span":{"begin":152,"end":161},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":126,"end":260},"obj":"Sentence"},{"id":"T9","span":{"begin":261,"end":528},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#ecaa93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#9396ec"},{"id":"LitCovid-PubTator","color":"#b0ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93ca"},{"id":"LitCovid-PD-CLO","color":"#93e4ec"},{"id":"LitCovid-PD-CHEBI","color":"#ecda93"},{"id":"LitCovid-PD-GO-BP","color":"#c093ec"},{"id":"LitCovid-sentences","color":"#93eca6"}]}]}}