PMC:7291971 / 788-1321
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 5-15 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T15 | 81-84 | GO:0008541 | denotes | cap |
| T16 | 107-112 | NCBITaxon:10239 | denotes | viral |
| T17 | 200-210 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T18 | 295-304 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T19 | 355-367 | NCBITaxon:31032 | denotes | flaviviruses |
| T20 | 371-379 | SP_10 | denotes | SARS-CoV |
| T21 | 461-469 | SP_10 | denotes | SARS-CoV |
| T50627 | 5-15 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T65425 | 81-84 | GO:0008541 | denotes | cap |
| T87174 | 107-112 | NCBITaxon:10239 | denotes | viral |
| T40194 | 200-210 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T7397 | 295-304 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T53306 | 355-367 | NCBITaxon:31032 | denotes | flaviviruses |
| T48802 | 371-379 | SP_10 | denotes | SARS-CoV |
| T86425 | 461-469 | SP_10 | denotes | SARS-CoV |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T6 | 85-88 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T7 | 168-175 | Body_part | denotes | adenine | http://purl.org/sig/ont/fma/fma82774 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 10 | 168-189 | Chemical | denotes | adenine dinucleosides | |
| 11 | 200-210 | Chemical | denotes | adenosines | MESH:D000241 |
| 12 | 232-240 | Chemical | denotes | nitrogen | MESH:D009584 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T4 | 371-379 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 461-469 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 317-323 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T9 | 5-15 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T10 | 168-175 | Chemical | denotes | adenine | http://purl.obolibrary.org/obo/CHEBI_16708 |
| T11 | 200-210 | Chemical | denotes | adenosines | http://purl.obolibrary.org/obo/CHEBI_22260 |
| T12 | 232-240 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 62-73 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T3 | 152-161 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T8 | 126-260 | Sentence | denotes | This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. |
| T9 | 261-528 | Sentence | denotes | Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. |