PMC:7291971 / 747-1319 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T14","span":{"begin":46,"end":56},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T15","span":{"begin":122,"end":125},"obj":"GO:0008541"},{"id":"T16","span":{"begin":148,"end":153},"obj":"NCBITaxon:10239"},{"id":"T17","span":{"begin":241,"end":251},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T18","span":{"begin":336,"end":345},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T19","span":{"begin":396,"end":408},"obj":"NCBITaxon:31032"},{"id":"T20","span":{"begin":412,"end":420},"obj":"SP_10"},{"id":"T21","span":{"begin":502,"end":510},"obj":"SP_10"},{"id":"T50627","span":{"begin":46,"end":56},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T65425","span":{"begin":122,"end":125},"obj":"GO:0008541"},{"id":"T87174","span":{"begin":148,"end":153},"obj":"NCBITaxon:10239"},{"id":"T40194","span":{"begin":241,"end":251},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T7397","span":{"begin":336,"end":345},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T53306","span":{"begin":396,"end":408},"obj":"NCBITaxon:31032"},{"id":"T48802","span":{"begin":412,"end":420},"obj":"SP_10"},{"id":"T86425","span":{"begin":502,"end":510},"obj":"SP_10"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":126,"end":129},"obj":"Body_part"},{"id":"T7","span":{"begin":209,"end":216},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82774"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PubTator","denotations":[{"id":"10","span":{"begin":209,"end":230},"obj":"Chemical"},{"id":"11","span":{"begin":241,"end":251},"obj":"Chemical"},{"id":"12","span":{"begin":273,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D000241"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:D009584"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"T5","span":{"begin":502,"end":510},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":358,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":46,"end":56},"obj":"Chemical"},{"id":"T10","span":{"begin":209,"end":216},"obj":"Chemical"},{"id":"T11","span":{"begin":241,"end":251},"obj":"Chemical"},{"id":"T12","span":{"begin":273,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22260"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":103,"end":114},"obj":"http://purl.obolibrary.org/obo/GO_0032259"},{"id":"T3","span":{"begin":193,"end":202},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":22,"end":166},"obj":"Sentence"},{"id":"T8","span":{"begin":167,"end":301},"obj":"Sentence"},{"id":"T9","span":{"begin":302,"end":569},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"tiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. Th"}