PMC:7291971 / 747-1319
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 46-56 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T15 | 122-125 | GO:0008541 | denotes | cap |
| T16 | 148-153 | NCBITaxon:10239 | denotes | viral |
| T17 | 241-251 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T18 | 336-345 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T19 | 396-408 | NCBITaxon:31032 | denotes | flaviviruses |
| T20 | 412-420 | SP_10 | denotes | SARS-CoV |
| T21 | 502-510 | SP_10 | denotes | SARS-CoV |
| T50627 | 46-56 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T65425 | 122-125 | GO:0008541 | denotes | cap |
| T87174 | 148-153 | NCBITaxon:10239 | denotes | viral |
| T40194 | 241-251 | CHEBI:22260;CHEBI:22260 | denotes | adenosines |
| T7397 | 336-345 | CHEBI:36357;CHEBI:36357 | denotes | compounds |
| T53306 | 396-408 | NCBITaxon:31032 | denotes | flaviviruses |
| T48802 | 412-420 | SP_10 | denotes | SARS-CoV |
| T86425 | 502-510 | SP_10 | denotes | SARS-CoV |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T6 | 126-129 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T7 | 209-216 | Body_part | denotes | adenine | http://purl.org/sig/ont/fma/fma82774 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 10 | 209-230 | Chemical | denotes | adenine dinucleosides | |
| 11 | 241-251 | Chemical | denotes | adenosines | MESH:D000241 |
| 12 | 273-281 | Chemical | denotes | nitrogen | MESH:D009584 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T4 | 412-420 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 502-510 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 358-364 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T9 | 46-56 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T10 | 209-216 | Chemical | denotes | adenine | http://purl.obolibrary.org/obo/CHEBI_16708 |
| T11 | 241-251 | Chemical | denotes | adenosines | http://purl.obolibrary.org/obo/CHEBI_22260 |
| T12 | 273-281 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 103-114 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
| T3 | 193-202 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7 | 22-166 | Sentence | denotes | We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. |
| T8 | 167-301 | Sentence | denotes | This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. |
| T9 | 302-569 | Sentence | denotes | Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. |