PMC:7291971 / 53618-54407 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1102","span":{"begin":85,"end":97},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T1103","span":{"begin":261,"end":265},"obj":"CHEBI:51231;CHEBI:51231"},{"id":"T86511","span":{"begin":85,"end":97},"obj":"CHEBI:38472;CHEBI:38472"},{"id":"T14604","span":{"begin":261,"end":265},"obj":"CHEBI:51231;CHEBI:51231"}],"text":"Following method C with 23 (40 mg, 0.45 mol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 5 (20 mg, 72%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm.1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"919","span":{"begin":342,"end":344},"obj":"Chemical"}],"attributes":[{"id":"A919","pred":"tao:has_database_id","subj":"919","obj":"MESH:D003903"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Following method C with 23 (40 mg, 0.45 mol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 5 (20 mg, 72%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm.1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T335","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T336","span":{"begin":175,"end":176},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Following method C with 23 (40 mg, 0.45 mol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 5 (20 mg, 72%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm.1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T17575","span":{"begin":85,"end":97},"obj":"Chemical"},{"id":"T86424","span":{"begin":107,"end":113},"obj":"Chemical"},{"id":"T108","span":{"begin":244,"end":246},"obj":"Chemical"},{"id":"T24815","span":{"begin":261,"end":265},"obj":"Chemical"},{"id":"T20156","span":{"begin":282,"end":284},"obj":"Chemical"},{"id":"T65687","span":{"begin":296,"end":298},"obj":"Chemical"},{"id":"T8029","span":{"begin":310,"end":312},"obj":"Chemical"},{"id":"T2651","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"T5457","span":{"begin":386,"end":388},"obj":"Chemical"},{"id":"T115","span":{"begin":412,"end":414},"obj":"Chemical"},{"id":"T28173","span":{"begin":457,"end":459},"obj":"Chemical"},{"id":"T85971","span":{"begin":483,"end":485},"obj":"Chemical"},{"id":"T74956","span":{"begin":515,"end":517},"obj":"Chemical"},{"id":"T36399","span":{"begin":547,"end":549},"obj":"Chemical"},{"id":"T49547","span":{"begin":573,"end":575},"obj":"Chemical"},{"id":"T89992","span":{"begin":644,"end":646},"obj":"Chemical"}],"attributes":[{"id":"A17503","pred":"chebi_id","subj":"T17575","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A26477","pred":"chebi_id","subj":"T86424","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"},{"id":"A99157","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A45204","pred":"chebi_id","subj":"T24815","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A26917","pred":"chebi_id","subj":"T20156","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A1029","pred":"chebi_id","subj":"T65687","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A69071","pred":"chebi_id","subj":"T8029","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A15046","pred":"chebi_id","subj":"T2651","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A28452","pred":"chebi_id","subj":"T5457","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A79910","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A65818","pred":"chebi_id","subj":"T28173","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A9025","pred":"chebi_id","subj":"T85971","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A1044","pred":"chebi_id","subj":"T74956","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A83323","pred":"chebi_id","subj":"T36399","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A60424","pred":"chebi_id","subj":"T49547","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A66813","pred":"chebi_id","subj":"T89992","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"}],"text":"Following method C with 23 (40 mg, 0.45 mol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 5 (20 mg, 72%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm.1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T381","span":{"begin":0,"end":789},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Following method C with 23 (40 mg, 0.45 mol, 1.00 eq) and a 0–50% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7 for purification, 5 (20 mg, 72%) was obtained as a white powder with 98% purity determined by HPLC analysis at 260 nm.1H NMR (500 MHz, DMSO‑d 6) δ 8.36 (s, 1H), 8.32 (s, 1H), 8.14 (s, 1H), 8.13 (s, 1H), 7.33 (br. s, 2H), 7.25 (br. s, 2H), 5.97 (d, J = 6.3 Hz, 1H), 5.85 (d, J = 5.2 Hz, 1H), 5.49–5.39 (m, 3H), 5.14 (d, J = 5.3 Hz, 1H), 4.62 (q, J = 5.4 Hz, 1H), 4.52 (dd, J = 6.5, 4.7 Hz, 1H), 4.29 (dd, J = 4.8, 2.8 Hz, 1H), 4.06 (q, J = 4.9 Hz, 1H), 4.00–3.92 (m, 2H), 3.68–3.46 (m, 4H), 2.79 (dd, J = 14.0, 4.6 Hz, 1H), 2.70–2.51 (m, 3H), 2.41–2.30 (m, 2H), 1.22 (q, J = 7.4, 2H), 1.07 (tdd, J = 13.4 Hz, J = 10.5 Hz, J = 6.3 Hz, 2H), 0.73 (t, J = 7.3 Hz, 2H)."}