PMC:7291971 / 47354-47874 JSONTXT

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{"project":"LitCovid-PubTator","denotations":[{"id":"830","span":{"begin":38,"end":41},"obj":"Chemical"},{"id":"831","span":{"begin":55,"end":60},"obj":"Chemical"},{"id":"832","span":{"begin":174,"end":177},"obj":"Chemical"},{"id":"833","span":{"begin":181,"end":185},"obj":"Chemical"},{"id":"834","span":{"begin":331,"end":341},"obj":"Chemical"},{"id":"835","span":{"begin":398,"end":410},"obj":"Chemical"},{"id":"836","span":{"begin":414,"end":419},"obj":"Chemical"}],"attributes":[{"id":"A830","pred":"tao:has_database_id","subj":"830","obj":"MESH:D014269"},{"id":"A831","pred":"tao:has_database_id","subj":"831","obj":"MESH:D014867"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"MESH:D058428"},{"id":"A835","pred":"tao:has_database_id","subj":"835","obj":"MESH:C032159"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" was treated at room temperature with TFA (1.44 mL) in water (360 μL) and stirred for 3 h at room temperature. The solvents were removed and the residue was treated with 7 M NH3 in MeOH (10 mL). After stirring for 24 h at 30 °C, solvents were removed and the residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a 0–15% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophil"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T320","span":{"begin":314,"end":315},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T321","span":{"begin":371,"end":372},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":" was treated at room temperature with TFA (1.44 mL) in water (360 μL) and stirred for 3 h at room temperature. The solvents were removed and the residue was treated with 7 M NH3 in MeOH (10 mL). After stirring for 24 h at 30 °C, solvents were removed and the residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a 0–15% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophil"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T889","span":{"begin":38,"end":41},"obj":"Chemical"},{"id":"T890","span":{"begin":55,"end":60},"obj":"Chemical"},{"id":"T891","span":{"begin":115,"end":123},"obj":"Chemical"},{"id":"T892","span":{"begin":174,"end":177},"obj":"Chemical"},{"id":"T893","span":{"begin":181,"end":185},"obj":"Chemical"},{"id":"T894","span":{"begin":229,"end":237},"obj":"Chemical"},{"id":"T895","span":{"begin":331,"end":337},"obj":"Chemical"},{"id":"T896","span":{"begin":398,"end":410},"obj":"Chemical"},{"id":"T897","span":{"begin":420,"end":426},"obj":"Chemical"}],"attributes":[{"id":"A889","pred":"chebi_id","subj":"T889","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A890","pred":"chebi_id","subj":"T890","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A891","pred":"chebi_id","subj":"T891","obj":"http://purl.obolibrary.org/obo/CHEBI_46787"},{"id":"A892","pred":"chebi_id","subj":"T892","obj":"http://purl.obolibrary.org/obo/CHEBI_16134"},{"id":"A893","pred":"chebi_id","subj":"T893","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A894","pred":"chebi_id","subj":"T894","obj":"http://purl.obolibrary.org/obo/CHEBI_46787"},{"id":"A895","pred":"chebi_id","subj":"T895","obj":"http://purl.obolibrary.org/obo/CHEBI_30563"},{"id":"A896","pred":"chebi_id","subj":"T896","obj":"http://purl.obolibrary.org/obo/CHEBI_38472"},{"id":"A897","pred":"chebi_id","subj":"T897","obj":"http://purl.obolibrary.org/obo/CHEBI_35225"}],"text":" was treated at room temperature with TFA (1.44 mL) in water (360 μL) and stirred for 3 h at room temperature. The solvents were removed and the residue was treated with 7 M NH3 in MeOH (10 mL). After stirring for 24 h at 30 °C, solvents were removed and the residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a 0–15% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophil"}

{"project":"LitCovid-sentences","denotations":[{"id":"T344","span":{"begin":111,"end":194},"obj":"Sentence"},{"id":"T345","span":{"begin":195,"end":439},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" was treated at room temperature with TFA (1.44 mL) in water (360 μL) and stirred for 3 h at room temperature. The solvents were removed and the residue was treated with 7 M NH3 in MeOH (10 mL). After stirring for 24 h at 30 °C, solvents were removed and the residue was purified by flash column chromatography on a reversed-phase silica gel column C18 (4 g, 40 μm) with a 0–15% linear gradient of acetonitrile in TEAAc buffer 50 mM, pH 7. The fractions containing the pure compound were pooled, concentrated and lyophil"}