PMC:7291971 / 36044-36920
Annnotations
LitCovid-PMC-OGER-BB
{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T742","span":{"begin":49,"end":81},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T743","span":{"begin":85,"end":86},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T744","span":{"begin":86,"end":88},"obj":"CHEBI:52029;CHEBI:52029"},{"id":"T745","span":{"begin":88,"end":101},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T746","span":{"begin":101,"end":107},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T747","span":{"begin":109,"end":111},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T748","span":{"begin":111,"end":123},"obj":"CHEBI:27798;CHEBI:27798"},{"id":"T749","span":{"begin":123,"end":126},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T750","span":{"begin":126,"end":137},"obj":"CHEBI:35358;CHEBI:35358"},{"id":"T751","span":{"begin":167,"end":168},"obj":"CHEBI:75508;CHEBI:75508"},{"id":"T752","span":{"begin":168,"end":169},"obj":"CHEBI:82321;CHEBI:82321"},{"id":"T753","span":{"begin":169,"end":170},"obj":"CHEBI:50217;CHEBI:50217"},{"id":"T754","span":{"begin":170,"end":175},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T755","span":{"begin":175,"end":177},"obj":"CHEBI:50217;CHEBI:50217"},{"id":"T756","span":{"begin":177,"end":196},"obj":"CHEBI:53250;CHEBI:53250"},{"id":"T757","span":{"begin":197,"end":206},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T758","span":{"begin":240,"end":261},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T759","span":{"begin":262,"end":270},"obj":"CHEBI:17996;CHEBI:17996"},{"id":"T760","span":{"begin":334,"end":338},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T761","span":{"begin":662,"end":665},"obj":"CHEBI:36927;CHEBI:36927"},{"id":"T86118","span":{"begin":49,"end":81},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T62627","span":{"begin":85,"end":86},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T73292","span":{"begin":86,"end":88},"obj":"CHEBI:52029;CHEBI:52029"},{"id":"T56519","span":{"begin":88,"end":101},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T95710","span":{"begin":101,"end":107},"obj":"CHEBI:16625;CHEBI:16625"},{"id":"T45397","span":{"begin":109,"end":111},"obj":"CHEBI:53233;CHEBI:53233"},{"id":"T96670","span":{"begin":111,"end":123},"obj":"CHEBI:27798;CHEBI:27798"},{"id":"T69786","span":{"begin":123,"end":126},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T24453","span":{"begin":126,"end":137},"obj":"CHEBI:35358;CHEBI:35358"},{"id":"T31575","span":{"begin":167,"end":168},"obj":"CHEBI:75508;CHEBI:75508"},{"id":"T96563","span":{"begin":168,"end":169},"obj":"CHEBI:82321;CHEBI:82321"},{"id":"T43267","span":{"begin":169,"end":170},"obj":"CHEBI:50217;CHEBI:50217"},{"id":"T88305","span":{"begin":170,"end":175},"obj":"CHEBI:46882;CHEBI:46882"},{"id":"T5438","span":{"begin":175,"end":177},"obj":"CHEBI:50217;CHEBI:50217"},{"id":"T60092","span":{"begin":177,"end":196},"obj":"CHEBI:53250;CHEBI:53250"},{"id":"T29954","span":{"begin":197,"end":206},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T50196","span":{"begin":240,"end":261},"obj":"CHEBI:86228;CHEBI:86228"},{"id":"T14448","span":{"begin":262,"end":270},"obj":"CHEBI:17996;CHEBI:17996"},{"id":"T79305","span":{"begin":334,"end":338},"obj":"CHEBI:32145;CHEBI:32145"},{"id":"T69919","span":{"begin":662,"end":665},"obj":"CHEBI:36927;CHEBI:36927"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"613","span":{"begin":197,"end":206},"obj":"Chemical"},{"id":"614","span":{"begin":240,"end":270},"obj":"Chemical"},{"id":"615","span":{"begin":334,"end":338},"obj":"Chemical"},{"id":"616","span":{"begin":339,"end":342},"obj":"Chemical"},{"id":"617","span":{"begin":345,"end":347},"obj":"Chemical"},{"id":"618","span":{"begin":362,"end":368},"obj":"Chemical"},{"id":"619","span":{"begin":395,"end":397},"obj":"Chemical"},{"id":"620","span":{"begin":414,"end":416},"obj":"Chemical"},{"id":"621","span":{"begin":428,"end":430},"obj":"Chemical"},{"id":"622","span":{"begin":442,"end":444},"obj":"Chemical"},{"id":"623","span":{"begin":461,"end":463},"obj":"Chemical"},{"id":"624","span":{"begin":479,"end":481},"obj":"Chemical"},{"id":"625","span":{"begin":505,"end":507},"obj":"Chemical"},{"id":"626","span":{"begin":540,"end":542},"obj":"Chemical"},{"id":"627","span":{"begin":575,"end":577},"obj":"Chemical"},{"id":"628","span":{"begin":610,"end":612},"obj":"Chemical"},{"id":"629","span":{"begin":629,"end":631},"obj":"Chemical"},{"id":"630","span":{"begin":643,"end":645},"obj":"Chemical"},{"id":"631","span":{"begin":657,"end":659},"obj":"Chemical"},{"id":"632","span":{"begin":662,"end":665},"obj":"Chemical"},{"id":"633","span":{"begin":680,"end":688},"obj":"Chemical"},{"id":"634","span":{"begin":831,"end":842},"obj":"Chemical"},{"id":"635","span":{"begin":804,"end":808},"obj":"Disease"}],"attributes":[{"id":"A613","pred":"tao:has_database_id","subj":"613","obj":"MESH:D000241"},{"id":"A620","pred":"tao:has_database_id","subj":"620","obj":"MESH:D003903"},{"id":"A623","pred":"tao:has_database_id","subj":"623","obj":"MESH:D003903"},{"id":"A624","pred":"tao:has_database_id","subj":"624","obj":"MESH:D003903"},{"id":"A629","pred":"tao:has_database_id","subj":"629","obj":"MESH:D003903"},{"id":"A630","pred":"tao:has_database_id","subj":"630","obj":"MESH:D014316"},{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"MESH:D014316"},{"id":"A632","pred":"tao:has_database_id","subj":"632","obj":"MESH:C000615229"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T272","span":{"begin":139,"end":141},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T273","span":{"begin":160,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T274","span":{"begin":272,"end":274},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T275","span":{"begin":305,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T276","span":{"begin":844,"end":847},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T588","span":{"begin":22,"end":43},"obj":"Chemical"},{"id":"T589","span":{"begin":24,"end":29},"obj":"Chemical"},{"id":"T590","span":{"begin":49,"end":57},"obj":"Chemical"},{"id":"T592","span":{"begin":101,"end":107},"obj":"Chemical"},{"id":"T594","span":{"begin":111,"end":123},"obj":"Chemical"},{"id":"T595","span":{"begin":126,"end":137},"obj":"Chemical"},{"id":"T596","span":{"begin":170,"end":175},"obj":"Chemical"},{"id":"T597","span":{"begin":182,"end":196},"obj":"Chemical"},{"id":"T598","span":{"begin":197,"end":206},"obj":"Chemical"},{"id":"T599","span":{"begin":262,"end":270},"obj":"Chemical"},{"id":"T600","span":{"begin":320,"end":322},"obj":"Chemical"},{"id":"T601","span":{"begin":334,"end":338},"obj":"Chemical"},{"id":"T602","span":{"begin":339,"end":342},"obj":"Chemical"},{"id":"T603","span":{"begin":345,"end":347},"obj":"Chemical"},{"id":"T604","span":{"begin":362,"end":366},"obj":"Chemical"},{"id":"T605","span":{"begin":395,"end":397},"obj":"Chemical"},{"id":"T606","span":{"begin":428,"end":430},"obj":"Chemical"},{"id":"T607","span":{"begin":442,"end":444},"obj":"Chemical"},{"id":"T608","span":{"begin":505,"end":507},"obj":"Chemical"},{"id":"T609","span":{"begin":540,"end":542},"obj":"Chemical"},{"id":"T610","span":{"begin":575,"end":577},"obj":"Chemical"},{"id":"T611","span":{"begin":610,"end":612},"obj":"Chemical"},{"id":"T612","span":{"begin":680,"end":684},"obj":"Chemical"}],"attributes":[{"id":"A588","pred":"chebi_id","subj":"T588","obj":"http://purl.obolibrary.org/obo/CHEBI_30756"},{"id":"A589","pred":"chebi_id","subj":"T589","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A590","pred":"chebi_id","subj":"T590","obj":"http://purl.obolibrary.org/obo/CHEBI_33601"},{"id":"A591","pred":"chebi_id","subj":"T590","obj":"http://purl.obolibrary.org/obo/CHEBI_42266"},{"id":"A592","pred":"chebi_id","subj":"T592","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A593","pred":"chebi_id","subj":"T592","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A594","pred":"chebi_id","subj":"T594","obj":"http://purl.obolibrary.org/obo/CHEBI_27798"},{"id":"A595","pred":"chebi_id","subj":"T595","obj":"http://purl.obolibrary.org/obo/CHEBI_35358"},{"id":"A596","pred":"chebi_id","subj":"T596","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A597","pred":"chebi_id","subj":"T597","obj":"http://purl.obolibrary.org/obo/CHEBI_29858"},{"id":"A598","pred":"chebi_id","subj":"T598","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A599","pred":"chebi_id","subj":"T599","obj":"http://purl.obolibrary.org/obo/CHEBI_17996"},{"id":"A600","pred":"chebi_id","subj":"T600","obj":"http://purl.obolibrary.org/obo/CHEBI_33346"},{"id":"A601","pred":"chebi_id","subj":"T601","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A602","pred":"chebi_id","subj":"T602","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A603","pred":"chebi_id","subj":"T603","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A604","pred":"chebi_id","subj":"T604","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A605","pred":"chebi_id","subj":"T605","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A606","pred":"chebi_id","subj":"T606","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A607","pred":"chebi_id","subj":"T607","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A608","pred":"chebi_id","subj":"T608","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A609","pred":"chebi_id","subj":"T609","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A610","pred":"chebi_id","subj":"T610","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A611","pred":"chebi_id","subj":"T611","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A612","pred":"chebi_id","subj":"T612","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T4","span":{"begin":339,"end":342},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T266","span":{"begin":0,"end":142},"obj":"Sentence"},{"id":"T267","span":{"begin":143,"end":319},"obj":"Sentence"},{"id":"T268","span":{"begin":320,"end":344},"obj":"Sentence"},{"id":"T269","span":{"begin":345,"end":661},"obj":"Sentence"},{"id":"T270","span":{"begin":662,"end":803},"obj":"Sentence"},{"id":"T271","span":{"begin":804,"end":850},"obj":"Sentence"},{"id":"T272","span":{"begin":851,"end":876},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.3 N-{[(4R,6R)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d] [1,3]dioxol-4-yl]methyl}-4-nitrobenzene-1-sulfonamide (18)\nFollowing method A with 5′-amino-2′,3′-isopropylidene adenosine (2.21 g, 7.22 mmol, 1.00 eq) and 4-nitrobenzenesufonyl chloride, 18 (2.64 g, 74%) was obtained as a beige solid. Rf 0.50 (8:92 MeOH/DCM). 1H NMR (600 MHz, DMSO‑d 6) δ 8.55 (t, J = 5.8 Hz, 1H), 8.33–8.27 (m, 2H), 8.26 (s, 1H), 8.13 (s, 1H), 7.96–7.88 (m, 2H), 7.37 (br. s, 2H), 6.09 (d, J = 2.8 Hz, 1H), 5.32 (dd, J = 6.3 Hz, 2.9 Hz, 1H), 4.89 (dd, J = 6.3 Hz, 3.0 Hz, 1H), 4.16 (td, J = 5.9 Hz, 3.0 Hz, 1H), 3.24–3.10 (m, 2H), 1.50 (s, 3H), 1.27 (s, 3H). 13C NMR (600 MHz, DMSO‑d 6) δ 156.3, 152.7, 149.5, 148.4, 146.0, 140.2, 128.0, 124.5, 119.3, 113.6, 89.4, 84.4, 83.0, 81.6, 44.6, 27.0, 25.2. HRMS (ESI+): m/z calcd for C19H22N7O7S [M+H]+: 492.1301, Found 492.1311."}