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PMC:7291971 / 32300-34217 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T684 123-124 GO:0006272 denotes O
T685 124-136 GO:0036123 denotes -methylation
T686 137-139 GO:0097152 denotes of
T687 144-147 GO:0008541 denotes cap
T688 158-168 CHEBI:22260;CHEBI:22260 denotes adenosines
T689 336-345 CHEBI:22260;CHEBI:22260 denotes adenosine
T690 364-372 CHEBI:23357;CHEBI:23357 denotes cofactor
T691 485-497 NCBITaxon:31032 denotes flaviviruses
T692 499-510 NCBITaxon:11118 denotes coronavirus
T693 514-517 NCBITaxon:9258 denotes pox
T694 517-518 NCBITaxon:4896 denotes -
T695 518-523 NCBITaxon:10239 denotes virus
T696 569-577 SP_10 denotes SARS-CoV
T697 578-583 PR:000000125 denotes nsp14
T698 701-710 CHEBI:36357;CHEBI:36357 denotes compounds
T699 730-735 SP_6;NCBITaxon:9606 denotes human
T700 845-856 NCBITaxon:11118 denotes coronavirus
T701 901-909 SO:0000853 denotes homology
T702 918-923 NCBITaxon:10239 denotes viral
T703 984-994 CHEBI:35222;CHEBI:35222 denotes inhibitors
T704 1081-1083 CHEBI:86228;CHEBI:86228 denotes 4-
T705 1083-1089 CHEBI:47853;CHEBI:47853 denotes chloro
T706 1089-1115 CHEBI:86228;CHEBI:86228 denotes -3-nitrobenzenesulfonamide
T707 1152-1162 CHEBI:28748;CHEBI:28748 denotes adenosines
T708 1192-1200 SP_10 denotes SARS-CoV
T709 1529-1537 SP_10 denotes SARS-CoV
T710 1538-1543 PR:000000125 denotes nsp14
T711 1601-1611 SP_7 denotes SARS-CoV-2
T712 1612-1617 PR:000000125 denotes nsp14
T713 1673-1679 SO:0001026 denotes genome
T714 1692-1702 SP_7 denotes SARS-CoV-2
T715 1753-1761 SP_10 denotes SARS-CoV
T716 1783-1791 CHEBI:36357;CHEBI:36357 denotes compound
T717 1889-1899 SP_7 denotes SARS-CoV-2
T718 1900-1905 PR:000000125 denotes nsp14
T719 1906-1916 CHEBI:35222;CHEBI:35222 denotes inhibitors
T69159 123-124 GO:0006272 denotes O
T43711 124-136 GO:0036123 denotes -methylation
T81564 137-139 GO:0097152 denotes of
T70474 144-147 GO:0008541 denotes cap
T41314 158-168 CHEBI:22260;CHEBI:22260 denotes adenosines
T23726 336-345 CHEBI:22260;CHEBI:22260 denotes adenosine
T98548 364-372 CHEBI:23357;CHEBI:23357 denotes cofactor
T92328 485-497 NCBITaxon:31032 denotes flaviviruses
T24605 499-510 NCBITaxon:11118 denotes coronavirus
T78621 514-517 NCBITaxon:9258 denotes pox
T7158 517-518 NCBITaxon:4896 denotes -
T18275 518-523 NCBITaxon:10239 denotes virus
T29561 569-577 SP_10 denotes SARS-CoV
T7597 578-583 PR:000000125 denotes nsp14
T54566 701-710 CHEBI:36357;CHEBI:36357 denotes compounds
T98305 730-735 SP_6;NCBITaxon:9606 denotes human
T14451 845-856 NCBITaxon:11118 denotes coronavirus
T51183 901-909 SO:0000853 denotes homology
T79023 918-923 NCBITaxon:10239 denotes viral
T82178 984-994 CHEBI:35222;CHEBI:35222 denotes inhibitors
T61222 1081-1083 CHEBI:86228;CHEBI:86228 denotes 4-
T60782 1083-1089 CHEBI:47853;CHEBI:47853 denotes chloro
T84456 1089-1115 CHEBI:86228;CHEBI:86228 denotes -3-nitrobenzenesulfonamide
T6725 1152-1162 CHEBI:28748;CHEBI:28748 denotes adenosines
T96719 1192-1200 SP_10 denotes SARS-CoV
T5588 1529-1537 SP_10 denotes SARS-CoV
T96029 1538-1543 PR:000000125 denotes nsp14
T31767 1601-1611 SP_7 denotes SARS-CoV-2
T33421 1612-1617 PR:000000125 denotes nsp14
T98006 1673-1679 SO:0001026 denotes genome
T89107 1692-1702 SP_7 denotes SARS-CoV-2
T30986 1753-1761 SP_10 denotes SARS-CoV
T14527 1783-1791 CHEBI:36357;CHEBI:36357 denotes compound
T75722 1889-1899 SP_7 denotes SARS-CoV-2
T45819 1900-1905 PR:000000125 denotes nsp14
T90350 1906-1916 CHEBI:35222;CHEBI:35222 denotes inhibitors

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T95 18-25 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T96 148-151 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T97 304-308 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T98 736-739 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T99 1445-1449 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T100 1618-1625 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T101 1673-1679 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
544 18-39 Chemical denotes adenine dinucleosides
545 158-168 Chemical denotes adenosines MESH:D000241
546 256-265 Chemical denotes adenosine MESH:D000241
547 336-345 Chemical denotes adenosine MESH:D000241
548 1053-1065 Chemical denotes dinucleoside
549 1081-1115 Chemical denotes 4-chloro-3-nitrobenzenesulfonamide
550 1152-1162 Chemical denotes adenosines MESH:D000241
551 1265-1275 Chemical denotes sinefungin MESH:C006235

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T91 569-577 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 1192-1200 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 1529-1537 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 1601-1609 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T95 1692-1700 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T96 1753-1761 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 1889-1897 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T247 518-523 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T248 730-735 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T249 827-828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 1079-1080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 1180-1188 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T252 1285-1286 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T253 1385-1393 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T254 1632-1634 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T540 18-25 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T541 75-78 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T543 158-168 Chemical denotes adenosines http://purl.obolibrary.org/obo/CHEBI_22260
T544 195-197 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424
T546 256-265 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T547 290-300 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T548 336-345 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T549 360-363 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T551 364-372 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T552 428-431 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T554 794-803 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T555 857-866 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T556 984-994 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T557 1083-1089 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T558 1152-1162 Chemical denotes adenosines http://purl.obolibrary.org/obo/CHEBI_22260
T559 1265-1275 Chemical denotes sinefungin http://purl.obolibrary.org/obo/CHEBI_45453
T560 1437-1440 Chemical denotes SAM http://purl.obolibrary.org/obo/CHEBI_15414|http://purl.obolibrary.org/obo/CHEBI_67040
T562 1618-1625 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T563 1906-1916 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T43 125-136 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T44 380-391 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation

2_test

Id Subject Object Predicate Lexical cue
32563813-32007145-29105595 1769-1771 32007145 denotes 38

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T233 0-152 Sentence denotes We synthesized 16 adenine dinucleosides which were designed as bisubstrate SAM analogs to mimic the transition state of 2′-O-methylation of the cap RNA.
T234 153-401 Sentence denotes Both adenosines were connected by various NH or N-substituted linkers between the 2′-O-position of the adenosine representing the 5′-end nucleoside of mRNA and the 5′-position of the adenosine mimicking the SAM cofactor in the methylation reaction.
T235 402-534 Sentence denotes None of these bisubstrate SAM analogs were found to inhibit 2′-O MTases of several flaviviruses, coronavirus or pox-virus at 200 μM.
T236 535-658 Sentence denotes Conversely, six of them inhibited SARS-CoV nsp14 N7-MTase in micromolar range concentration and one in submicromolar range.
T237 659-877 Sentence denotes Additionally, we also observed that these compounds barely inhibit the human RNA N7 MTase, an important feature given that the lack of antiviral specificity represents a common issue in coronavirus antiviral discovery.
T238 878-1012 Sentence denotes Indeed, the structural homology between viral and cellular MTases often impairs the discovery of specific inhibitors for CoV N7-MTase.
T239 1013-1311 Sentence denotes Nevertheless, our work did identify one dinucleoside (13) bearing a 4-chloro-3-nitrobenzenesulfonamide moiety in the N-linker between both adenosines, that blocks the activity of SARS-CoV nsp14 at the submicromolar concentration in the same range than sinefungin but with a significant specificity.
T240 1312-1475 Sentence denotes Thermal shift assays and molecular modeling indicate that the inhibitory activity is likely due to the binding of 13 to both SAM and mRNA binding pockets of nsp14.
T241 1476-1660 Sentence denotes It is quite interesting to note that all residues of SARS-CoV nsp14 involved in the binding of 13 are fully conserved in the SARS-CoV-2 nsp14 protein (Fig. S1, Supporting Information).
T242 1661-1773 Sentence denotes Indeed, the genome sequence of SARS-CoV-2 nsp14 exhibits about 95% sequence similarity with SARS-CoV nsp14 [38].
T243 1774-1917 Sentence denotes The lead compound 13 and the most potent derivatives will serve as starting building blocks for the development of SARS-CoV-2 nsp14 inhibitors.

MyTest

Id Subject Object Predicate Lexical cue
32563813-32007145-29105595 1769-1771 32007145 denotes 38