PMC:7291971 / 26398-26719 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T565","span":{"begin":65,"end":74},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T566","span":{"begin":114,"end":122},"obj":"SP_10"},{"id":"T567","span":{"begin":309,"end":317},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T603","span":{"begin":122,"end":130},"obj":"SP_10"},{"id":"T604","span":{"begin":131,"end":136},"obj":"PR:000000125"},{"id":"T605","span":{"begin":189,"end":200},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T606","span":{"begin":201,"end":211},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T607","span":{"begin":245,"end":253},"obj":"SP_10"},{"id":"T608","span":{"begin":254,"end":259},"obj":"PR:000000125"}],"text":"Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T75","span":{"begin":114,"end":122},"obj":"Disease"}],"attributes":[{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T218","span":{"begin":163,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T219","span":{"begin":262,"end":265},"obj":"http://purl.obolibrary.org/obo/CLO_0009405"}],"text":"Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T443","span":{"begin":65,"end":74},"obj":"Chemical"},{"id":"T444","span":{"begin":227,"end":229},"obj":"Chemical"},{"id":"T445","span":{"begin":262,"end":265},"obj":"Chemical"}],"attributes":[{"id":"A443","pred":"chebi_id","subj":"T443","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A444","pred":"chebi_id","subj":"T444","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"},{"id":"A445","pred":"chebi_id","subj":"T445","obj":"http://purl.obolibrary.org/obo/CHEBI_46024"}],"text":"Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13."}

{"project":"LitCovid-sentences","denotations":[{"id":"T191","span":{"begin":0,"end":321},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13."}