PMC:7291971 / 26398-26719
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T565 | 65-74 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
| T566 | 114-122 | SP_10 | denotes | SARS-CoV |
| T567 | 309-317 | CHEBI:36357;CHEBI:36357 | denotes | compound |
| T603 | 122-130 | SP_10 | denotes | nsp14 a |
| T604 | 131-136 | PR:000000125 | denotes | ainst |
| T605 | 189-200 | CHEBI:23447;CHEBI:23447 | denotes | ts notable |
| T606 | 201-211 | CHEBI:35222;CHEBI:35222 | denotes | inding aff |
| T607 | 245-253 | SP_10 | denotes | as dedu |
| T608 | 254-259 | PR:000000125 | denotes | ed fr |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T75 | 114-122 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T218 | 163-164 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T219 | 262-265 | http://purl.obolibrary.org/obo/CLO_0009405 | denotes | TSA |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T443 | 65-74 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T444 | 227-229 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
| T445 | 262-265 | Chemical | denotes | TSA | http://purl.obolibrary.org/obo/CHEBI_46024 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T191 | 0-321 | Sentence | denotes | Remarkably, the highest T m was observed with the most efficient inhibitor 13 (IC50 0.6 ± 0.1 μM) that stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔT m +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM), as deduced from TSA performed with increasing concentration of compound 13. |