PMC:7291971 / 24444-25169 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T536","span":{"begin":52,"end":61},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T537","span":{"begin":65,"end":73},"obj":"SP_10"},{"id":"T538","span":{"begin":84,"end":89},"obj":"SP_6;NCBITaxon:9606"},{"id":"T539","span":{"begin":126,"end":131},"obj":"PR:000000125"},{"id":"T31576","span":{"begin":92,"end":101},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T67246","span":{"begin":129,"end":137},"obj":"SP_10"},{"id":"T8618","span":{"begin":138,"end":143},"obj":"PR:000000125"},{"id":"T22326","span":{"begin":181,"end":190},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T4976","span":{"begin":238,"end":246},"obj":"SP_10"},{"id":"T14252","span":{"begin":289,"end":298},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T88128","span":{"begin":382,"end":391},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T62427","span":{"begin":471,"end":480},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T17572","span":{"begin":520,"end":528},"obj":"SP_10"},{"id":"T56144","span":{"begin":715,"end":723},"obj":"CHEBI:36357;CHEBI:36357"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T66","span":{"begin":65,"end":73},"obj":"Disease"},{"id":"T67","span":{"begin":117,"end":125},"obj":"Disease"}],"attributes":[{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T203","span":{"begin":45,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T204","span":{"begin":84,"end":89},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T205","span":{"begin":95,"end":105},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T206","span":{"begin":258,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T207","span":{"begin":388,"end":389},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T208","span":{"begin":421,"end":429},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T209","span":{"begin":485,"end":486},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T210","span":{"begin":515,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T211","span":{"begin":530,"end":538},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T212","span":{"begin":582,"end":583},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}

{"project":"2_test","denotations":[{"id":"32563813-28676301-29105588","span":{"begin":515,"end":517},"obj":"28676301"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}

{"project":"LitCovid-sentences","denotations":[{"id":"T168","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"T169","span":{"begin":107,"end":157},"obj":"Sentence"},{"id":"T170","span":{"begin":158,"end":180},"obj":"Sentence"},{"id":"T171","span":{"begin":181,"end":204},"obj":"Sentence"},{"id":"T172","span":{"begin":205,"end":222},"obj":"Sentence"},{"id":"T173","span":{"begin":223,"end":239},"obj":"Sentence"},{"id":"T174","span":{"begin":240,"end":257},"obj":"Sentence"},{"id":"T175","span":{"begin":258,"end":284},"obj":"Sentence"},{"id":"T176","span":{"begin":285,"end":310},"obj":"Sentence"},{"id":"T177","span":{"begin":311,"end":336},"obj":"Sentence"},{"id":"T178","span":{"begin":337,"end":353},"obj":"Sentence"},{"id":"T179","span":{"begin":354,"end":370},"obj":"Sentence"},{"id":"T180","span":{"begin":371,"end":387},"obj":"Sentence"},{"id":"T181","span":{"begin":388,"end":484},"obj":"Sentence"},{"id":"T182","span":{"begin":485,"end":519},"obj":"Sentence"},{"id":"T183","span":{"begin":520,"end":725},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}

{"project":"MyTest","denotations":[{"id":"32563813-28676301-29105588","span":{"begin":515,"end":517},"obj":"28676301"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Table 2 Comparison of IC50 values of 10 most active compounds on SARS-CoV nsp14 and human RNMT activities.\nCompounds SARS-CoV nsp14 IC50a (μM) hRNMTIC50 (μM)\nSinefunginb 0.36 \u003c0.05\n2 40.6 ± 3.2 10.9 ± 1.0\n6 55.5 ± 5.1 \u003e500\n9 2.6 ± 0.2 \u003e500\n10 3.9 ± 0.4 \u003e500\n11 70.4 ± 4.9 169.3 ± 30.4\n12 5.7 ± 0.5 275.9 ± 28.7\n13 0.6 ± 0.1 247.5 ± 14.9\n14 1.5 ± 0.1 n.d\n15 2.4 ± 0.2 n.i\n16 9.9 ± 0.9 n.d\na Concentration inhibiting MTase activity by 50%; mean value from three independent experiments.\nb values from the literature [11]. The MTase activity for IC50 determinations was measured using a filter binding assay as described above. n.i: no inhibition detected at 50 μM; n.d: not determined due to inhibition lower than 50% at 50 μM."}