PMC:7291971 / 244-835 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"used by the recently emerged coronavirus SARS-CoV-2 is one significant and unfortunate example of what the world will have to face in the future with emerging viruses in absence of appropriate treatment. The discovery of potent and specific antiviral inhibitors and/or vaccines to fight these massive outbreaks is an urgent research priority. Enzymes involved in the capping pathway of viruses and more specifically RNA N7- or 2′O-methyltransferases (MTases) are now admitted as potential targets for antiviral chemotherapy. We designed bisubstrate inhibitors by mimicking the transition sta","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T8","span":{"begin":29,"end":40},"obj":"NCBITaxon:11118"},{"id":"T9","span":{"begin":41,"end":51},"obj":"SP_7"},{"id":"T10","span":{"begin":126,"end":130},"obj":"UBERON:0001456"},{"id":"T11","span":{"begin":159,"end":166},"obj":"NCBITaxon:10239"},{"id":"T12","span":{"begin":251,"end":261},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T13","span":{"begin":386,"end":393},"obj":"NCBITaxon:10239"},{"id":"T14","span":{"begin":549,"end":559},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T43008","span":{"begin":29,"end":40},"obj":"NCBITaxon:11118"},{"id":"T77356","span":{"begin":41,"end":51},"obj":"SP_7"},{"id":"T38673","span":{"begin":126,"end":130},"obj":"UBERON:0001456"},{"id":"T98319","span":{"begin":159,"end":166},"obj":"NCBITaxon:10239"},{"id":"T93340","span":{"begin":251,"end":261},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T49466","span":{"begin":386,"end":393},"obj":"NCBITaxon:10239"},{"id":"T50627","span":{"begin":549,"end":559},"obj":"CHEBI:35222;CHEBI:35222"}],"attributes":[{"subj":"T8","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43008","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77356","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T38673","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98319","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T93340","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49466","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T50627","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":126,"end":130},"obj":"Body_part"},{"id":"T5","span":{"begin":416,"end":419},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma24728"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":126,"end":130},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":41,"end":49},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T3","span":{"begin":126,"end":130},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T4","span":{"begin":159,"end":166},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T5","span":{"begin":386,"end":393},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":241,"end":250},"obj":"Chemical"},{"id":"T7","span":{"begin":251,"end":261},"obj":"Chemical"},{"id":"T8","span":{"begin":501,"end":510},"obj":"Chemical"},{"id":"T9","span":{"begin":549,"end":559},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T5","span":{"begin":204,"end":342},"obj":"Sentence"},{"id":"T6","span":{"begin":343,"end":524},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#ece793","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#cd93ec"},{"id":"LitCovid-PD-UBERON","color":"#93ecb3"},{"id":"LitCovid-PD-MONDO","color":"#ec9993"},{"id":"LitCovid-PD-CLO","color":"#93a7ec"},{"id":"LitCovid-PD-CHEBI","color":"#c1ec93"},{"id":"LitCovid-sentences","color":"#ec93db"}]}]}}