PMC:7291971 / 10915-11349 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"dinucleosides containing the N-arylsulfonamide motif.\nScheme 2 Synthesis of dinucleosides 1–9. (a) K2CO3, KI, DMF, 50 °C, 24 h, 74%; (b) PhSH, K2CO3, DMF, 25 °C, 2 h, 76%; (c) TFA/H2O 8/2, 25 °C, 3 h, 76% for 1 and 34% for 9; (d) (i) 21, AcOH, CH2Cl2, 25 °C, 2 h, (ii) NaBH(OAc)3, 25 °C, 2 h, 93%; (e) (i) TFA/H2O 8/2, 25 °C, 3 h, (ii) 2 M aqueous solution LiOH, 25 °C, 0.5 h, 32%; (f) TFA/H2O 8/2, 25 °C, 3 h, 35%; (g) (i) TFA/H2O 8/","divisions":[{"label":"label","span":{"begin":54,"end":62}}],"tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T215","span":{"begin":0,"end":13},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T216","span":{"begin":29,"end":30},"obj":"CHEBI:7586;CHEBI:7586"},{"id":"T217","span":{"begin":30,"end":31},"obj":"CHEBI:75508;CHEBI:75508"},{"id":"T218","span":{"begin":31,"end":46},"obj":"CHEBI:57472;CHEBI:57472"},{"id":"T219","span":{"begin":76,"end":89},"obj":"CHEBI:23447;CHEBI:23447"},{"id":"T220","span":{"begin":99,"end":104},"obj":"CHEBI:32031;CHEBI:32031"},{"id":"T221","span":{"begin":143,"end":148},"obj":"CHEBI:32031;CHEBI:32031"},{"id":"T222","span":{"begin":180,"end":183},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T223","span":{"begin":238,"end":242},"obj":"CHEBI:16236;CHEBI:16236"},{"id":"T224","span":{"begin":310,"end":313},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T225","span":{"begin":340,"end":347},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T226","span":{"begin":348,"end":356},"obj":"CHEBI:75958;CHEBI:75958"},{"id":"T227","span":{"begin":357,"end":361},"obj":"CHEBI:48607;CHEBI:48607"},{"id":"T228","span":{"begin":390,"end":393},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T229","span":{"begin":428,"end":431},"obj":"CHEBI:15377;CHEBI:15377"}],"attributes":[{"subj":"T215","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T216","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T217","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T218","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T219","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T220","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T221","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T222","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T223","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T224","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T225","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T226","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T227","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T228","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T229","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T49","span":{"begin":261,"end":268},"obj":"Body_part"},{"id":"T50","span":{"begin":328,"end":335},"obj":"Body_part"}],"attributes":[{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma278665"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma278665"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"109","span":{"begin":76,"end":89},"obj":"Chemical"},{"id":"110","span":{"begin":180,"end":183},"obj":"Chemical"},{"id":"111","span":{"begin":310,"end":313},"obj":"Chemical"},{"id":"112","span":{"begin":390,"end":393},"obj":"Chemical"},{"id":"113","span":{"begin":428,"end":431},"obj":"Chemical"},{"id":"200","span":{"begin":0,"end":13},"obj":"Chemical"},{"id":"201","span":{"begin":29,"end":46},"obj":"Chemical"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"attributes":[{"subj":"109","pred":"source","obj":"LitCovid-PubTator"},{"subj":"110","pred":"source","obj":"LitCovid-PubTator"},{"subj":"111","pred":"source","obj":"LitCovid-PubTator"},{"subj":"112","pred":"source","obj":"LitCovid-PubTator"},{"subj":"113","pred":"source","obj":"LitCovid-PubTator"},{"subj":"200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T77","span":{"begin":96,"end":97},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T78","span":{"begin":134,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T79","span":{"begin":159,"end":163},"obj":"http://purl.obolibrary.org/obo/CLO_0002105"},{"id":"T80","span":{"begin":159,"end":163},"obj":"http://purl.obolibrary.org/obo/CLO_0051742"},{"id":"T81","span":{"begin":186,"end":191},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"},{"id":"T82","span":{"begin":215,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T83","span":{"begin":230,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0004316"},{"id":"T84","span":{"begin":256,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0002105"},{"id":"T85","span":{"begin":256,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0051742"},{"id":"T86","span":{"begin":285,"end":289},"obj":"http://purl.obolibrary.org/obo/CLO_0002105"},{"id":"T87","span":{"begin":285,"end":289},"obj":"http://purl.obolibrary.org/obo/CLO_0051742"},{"id":"T88","span":{"begin":316,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"},{"id":"T89","span":{"begin":396,"end":401},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"},{"id":"T90","span":{"begin":411,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"attributes":[{"subj":"T77","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T149","span":{"begin":99,"end":104},"obj":"Chemical"},{"id":"T150","span":{"begin":106,"end":108},"obj":"Chemical"},{"id":"T152","span":{"begin":110,"end":113},"obj":"Chemical"},{"id":"T153","span":{"begin":143,"end":148},"obj":"Chemical"},{"id":"T154","span":{"begin":150,"end":153},"obj":"Chemical"},{"id":"T155","span":{"begin":176,"end":179},"obj":"Chemical"},{"id":"T156","span":{"begin":180,"end":183},"obj":"Chemical"},{"id":"T157","span":{"begin":238,"end":242},"obj":"Chemical"},{"id":"T158","span":{"begin":306,"end":309},"obj":"Chemical"},{"id":"T159","span":{"begin":310,"end":313},"obj":"Chemical"},{"id":"T160","span":{"begin":348,"end":356},"obj":"Chemical"},{"id":"T161","span":{"begin":357,"end":361},"obj":"Chemical"},{"id":"T162","span":{"begin":386,"end":389},"obj":"Chemical"},{"id":"T163","span":{"begin":390,"end":393},"obj":"Chemical"},{"id":"T164","span":{"begin":424,"end":427},"obj":"Chemical"},{"id":"T165","span":{"begin":428,"end":431},"obj":"Chemical"}],"attributes":[{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_131526"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_74559"},{"id":"A151","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_8346"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_17741"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_131526"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_17741"},{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_15366"},{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_75958"},{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_33979"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_45892"},{"id":"A165","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":63,"end":72},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T26","pred":"source","obj":"LitCovid-PD-GO-BP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#eca393","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#939cec"},{"id":"LitCovid-PubTator","color":"#b6ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93d0"},{"id":"LitCovid-PD-CHEBI","color":"#93eaec"},{"id":"LitCovid-PD-GO-BP","color":"#ecd393"}]}]}}