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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7291971","sourcedb":"PMC","sourceid":"7291971","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7291971","text":"Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range.","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T18","span":{"begin":34,"end":43},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T19","span":{"begin":94,"end":106},"obj":"NCBITaxon:31032"},{"id":"T20","span":{"begin":110,"end":118},"obj":"SP_10"},{"id":"T21","span":{"begin":200,"end":208},"obj":"SP_10"},{"id":"T7397","span":{"begin":34,"end":43},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T53306","span":{"begin":94,"end":106},"obj":"NCBITaxon:31032"},{"id":"T48802","span":{"begin":110,"end":118},"obj":"SP_10"},{"id":"T86425","span":{"begin":200,"end":208},"obj":"SP_10"}],"attributes":[{"subj":"T18","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7397","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T53306","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48802","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86425","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"T5","span":{"begin":200,"end":208},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T6","span":{"begin":56,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":267},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#a6ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93c0"},{"id":"LitCovid-PD-CLO","color":"#93daec"},{"id":"LitCovid-sentences","color":"#ece493"}]}]}}