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PMC:7289100 / 41292-42777 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T126 40-48 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T127 74-78 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T128 96-107 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T129 109-118 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T130 124-135 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T131 230-246 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T132 241-246 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T133 494-502 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T134 537-542 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T135 570-577 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T136 1088-1093 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T54 537-542 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T492 137-146 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T493 162-170 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T494 162-166 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T495 370-378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T496 370-374 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T497 381-390 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T498 392-400 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T499 421-433 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T500 446-465 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T306 8-9 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 61-62 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T308 74-84 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T309 109-118 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T310 124-135 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T311 179-180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 230-240 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T313 241-246 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T314 537-542 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T315 537-542 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T316 609-612 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T317 623-626 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T318 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 1046-1047 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 1088-1093 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T321 1106-1107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T322 1295-1296 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T168 0-2 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T170 210-212 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T172 262-264 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T174 553-555 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T176 570-577 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T177 691-693 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T179 812-823 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T180 955-966 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T181 1008-1014 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T182 1255-1266 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T183 1404-1415 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T184 1445-1455 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T211 446-465 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T19 324-346 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T20 421-433 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T252 0-136 Sentence denotes IL-6 is a pleiotropic, pro-inflammatory cytokine produced by a variety of cell types, including lymphocytes, monocytes, and fibroblasts.
T253 137-247 Sentence denotes Infection by the related SARS-CoV induces a dose-dependent production of IL-6 from bronchial epithelial cells.
T254 248-391 Sentence denotes Elevations in IL-6 levels may be an important mediator when severe systemic inflammatory responses occur in patients with SARS-CoV-2 infection.
T255 392-629 Sentence denotes COVID-19-associated systemic inflammation and hypoxic respiratory failure is associated with an acute cytokine release, as indicated by elevated blood levels of IL-6, C-reactive protein (CRP), D-dimer, and ferritin [[114], [115], [116]].
T256 630-740 Sentence denotes Few clinical studies aiming to evaluate the efficacy of anti-IL-6 receptor blocker have been published so far.
T257 741-934 Sentence denotes In a report from China by Xu et al. the authors were able to show that tocilizumab effectively improved clinical symptoms as well as reversed the deterioration of sever Covid-19 patients [117].
T258 935-1185 Sentence denotes Within 5 days after tocilizumab, 15 of the 20 patients had lowered their oxygen intake and 19 of the 20 showed a noticeable improvement in the CT of the lungs, as well as a significant reduction in CRP levels which was noted in 16 of the 19 patients.
T259 1186-1274 Sentence denotes All patients have been discharged on an average of 15 days after the tocilizumab dosing.
T260 1275-1361 Sentence denotes Even though this is a small and uncontrolled study, the results seem to be impressive.
T261 1362-1485 Sentence denotes Over 20 randomized controlled trials with tocilizumab, or sarilumab as well as JAK-inhibitors as baricitinib, are underway.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T557 0-4 PR:000001393 denotes IL-6
T558 96-107 CL:0000542 denotes lymphocytes
T559 109-118 CL:0000576 denotes monocytes
T560 124-135 CL:0000057 denotes fibroblasts
T561 162-170 SP_10 denotes SARS-CoV
T562 210-214 PR:000001393 denotes IL-6
T563 220-240 UBERON:0002031;CL:0002328 denotes bronchial epithelial
T564 241-246 CL:0002328 denotes cells
T565 262-266 PR:000001393 denotes IL-6
T566 370-380 SP_7 denotes SARS-CoV-2
T567 392-400 SP_7 denotes COVID-19
T568 446-457 UBERON:0001004 denotes respiratory
T569 537-542 UBERON:0000178 denotes blood
T570 553-557 PR:000001393 denotes IL-6
T571 559-577 PR:000005897 denotes C-reactive protein
T572 579-582 PR:000005897 denotes CRP
T573 691-695 PR:000001393 denotes IL-6
T574 812-823 DG_35 denotes tocilizumab
T575 910-918 SP_7 denotes Covid-19
T576 955-966 DG_35 denotes tocilizumab
T577 1088-1093 UBERON:0000170 denotes lungs
T578 1255-1266 DG_35 denotes tocilizumab
T579 1404-1415 DG_35 denotes tocilizumab
T580 1420-1429 DG_39 denotes sarilumab
T581 1445-1455 CHEBI:35222;CHEBI:35222 denotes inhibitors
T582 1459-1470 DG_41 denotes baricitinib
T21859 0-4 PR:000001393 denotes IL-6
T19136 96-107 CL:0000542 denotes lymphocytes
T28167 109-118 CL:0000576 denotes monocytes
T98906 124-135 CL:0000057 denotes fibroblasts
T25741 162-170 SP_10 denotes SARS-CoV
T11441 210-214 PR:000001393 denotes IL-6
T67653 220-240 UBERON:0002031;CL:0002328 denotes bronchial epithelial
T73773 241-246 CL:0002328 denotes cells
T15981 262-266 PR:000001393 denotes IL-6
T39306 370-380 SP_7 denotes SARS-CoV-2
T89461 392-400 SP_7 denotes COVID-19
T69527 446-457 UBERON:0001004 denotes respiratory
T63239 537-542 UBERON:0000178 denotes blood
T30193 553-557 PR:000001393 denotes IL-6
T46291 559-577 PR:000005897 denotes C-reactive protein
T28455 579-582 PR:000005897 denotes CRP
T70338 691-695 PR:000001393 denotes IL-6
T60533 812-823 DG_35 denotes tocilizumab
T64207 910-918 SP_7 denotes Covid-19
T25449 955-966 DG_35 denotes tocilizumab
T54606 1088-1093 UBERON:0000170 denotes lungs
T83703 1255-1266 DG_35 denotes tocilizumab
T67676 1404-1415 DG_35 denotes tocilizumab
T51113 1420-1429 DG_39 denotes sarilumab
T28736 1445-1455 CHEBI:35222;CHEBI:35222 denotes inhibitors
T15613 1459-1470 DG_41 denotes baricitinib

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1408 0-4 Gene denotes IL-6 Gene:3569
1409 210-214 Gene denotes IL-6 Gene:3569
1410 262-266 Gene denotes IL-6 Gene:3569
1411 553-557 Gene denotes IL-6 Gene:3569
1412 559-577 Gene denotes C-reactive protein Gene:1401
1413 579-582 Gene denotes CRP Gene:1401
1414 1133-1136 Gene denotes CRP Gene:1401
1415 162-170 Species denotes SARS-CoV Tax:694009
1416 356-364 Species denotes patients Tax:9606
1417 919-927 Species denotes patients Tax:9606
1418 981-989 Species denotes patients Tax:9606
1419 1176-1184 Species denotes patients Tax:9606
1420 1190-1198 Species denotes patients Tax:9606
1421 812-823 Chemical denotes tocilizumab MESH:C502936
1422 955-966 Chemical denotes tocilizumab MESH:C502936
1423 1008-1014 Chemical denotes oxygen MESH:D010100
1424 1255-1266 Chemical denotes tocilizumab MESH:C502936
1425 1404-1415 Chemical denotes tocilizumab MESH:C502936
1426 1420-1429 Chemical denotes sarilumab MESH:C000592401
1427 1459-1470 Chemical denotes baricitinib MESH:C000596027
1428 137-146 Disease denotes Infection MESH:D007239
1429 370-390 Disease denotes SARS-CoV-2 infection MESH:C000657245
1430 392-400 Disease denotes COVID-19 MESH:C000657245
1431 421-433 Disease denotes inflammation MESH:D007249
1432 438-465 Disease denotes hypoxic respiratory failure MESH:D012131
1433 910-918 Disease denotes Covid-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32535093-32171076-4828887 609-612 32171076 denotes 114
32535093-31986264-4828888 616-619 31986264 denotes 115