PMC:7289100 / 28688-29430 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T101","span":{"begin":387,"end":396},"obj":"Body_part"},{"id":"T102","span":{"begin":498,"end":502},"obj":"Body_part"},{"id":"T103","span":{"begin":620,"end":628},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T41","span":{"begin":387,"end":396},"obj":"Body_part"}],"attributes":[{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T368","span":{"begin":387,"end":410},"obj":"Disease"},{"id":"T369","span":{"begin":447,"end":450},"obj":"Disease"},{"id":"T370","span":{"begin":706,"end":714},"obj":"Disease"}],"attributes":[{"id":"A368","pred":"mondo_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/MONDO_0001956"},{"id":"A369","pred":"mondo_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/MONDO_0010787"},{"id":"A370","pred":"mondo_id","subj":"T370","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T231","span":{"begin":66,"end":67},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T123","span":{"begin":92,"end":100},"obj":"Chemical"},{"id":"T124","span":{"begin":169,"end":177},"obj":"Chemical"},{"id":"T125","span":{"begin":498,"end":500},"obj":"Chemical"},{"id":"T127","span":{"begin":561,"end":569},"obj":"Chemical"}],"attributes":[{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A126","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T179","span":{"begin":387,"end":401},"obj":"Phenotype"}],"attributes":[{"id":"A179","pred":"hp_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/HP_0030005"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T184","span":{"begin":0,"end":110},"obj":"Sentence"},{"id":"T185","span":{"begin":111,"end":340},"obj":"Sentence"},{"id":"T186","span":{"begin":341,"end":467},"obj":"Sentence"},{"id":"T187","span":{"begin":468,"end":742},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T406","span":{"begin":92,"end":100},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T407","span":{"begin":105,"end":109},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T408","span":{"begin":169,"end":177},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T409","span":{"begin":182,"end":186},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T410","span":{"begin":290,"end":294},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T411","span":{"begin":350,"end":354},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T412","span":{"begin":387,"end":396},"obj":"UBERON:0001982"},{"id":"T413","span":{"begin":556,"end":560},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T414","span":{"begin":561,"end":569},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T415","span":{"begin":694,"end":700},"obj":"UBERON:0007023"},{"id":"T416","span":{"begin":706,"end":714},"obj":"SP_7"},{"id":"T26559","span":{"begin":92,"end":100},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T64521","span":{"begin":105,"end":109},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T75793","span":{"begin":169,"end":177},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T52297","span":{"begin":182,"end":186},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T17659","span":{"begin":290,"end":294},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T68482","span":{"begin":350,"end":354},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T48537","span":{"begin":387,"end":396},"obj":"UBERON:0001982"},{"id":"T9746","span":{"begin":556,"end":560},"obj":"CHEBI:42098;CHEBI:42098"},{"id":"T39797","span":{"begin":561,"end":569},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T11659","span":{"begin":694,"end":700},"obj":"UBERON:0007023"},{"id":"T84045","span":{"begin":706,"end":714},"obj":"SP_7"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"974","span":{"begin":498,"end":502},"obj":"Gene"},{"id":"975","span":{"begin":34,"end":42},"obj":"Species"},{"id":"976","span":{"begin":92,"end":100},"obj":"Chemical"},{"id":"977","span":{"begin":169,"end":177},"obj":"Chemical"},{"id":"978","span":{"begin":447,"end":450},"obj":"Chemical"},{"id":"979","span":{"begin":561,"end":569},"obj":"Chemical"},{"id":"980","span":{"begin":387,"end":410},"obj":"Disease"},{"id":"981","span":{"begin":706,"end":714},"obj":"Disease"}],"attributes":[{"id":"A974","pred":"tao:has_database_id","subj":"974","obj":"Gene:3552"},{"id":"A975","pred":"tao:has_database_id","subj":"975","obj":"Tax:9606"},{"id":"A976","pred":"tao:has_database_id","subj":"976","obj":"MESH:D013256"},{"id":"A977","pred":"tao:has_database_id","subj":"977","obj":"MESH:D013256"},{"id":"A979","pred":"tao:has_database_id","subj":"979","obj":"MESH:D013256"},{"id":"A980","pred":"tao:has_database_id","subj":"980","obj":"MESH:D019559"},{"id":"A981","pred":"tao:has_database_id","subj":"981","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}

{"project":"2_test","denotations":[{"id":"32535093-31073478-4828882","span":{"begin":463,"end":465},"obj":"31073478"}],"text":"To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG. The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80]. Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81]. Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82]."}