PMC:7289100 / 28688-29430 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	fma_id
T101	387-396	Body_part	denotes	capillary	http://purl.org/sig/ont/fma/fma63194
T102	498-502	Body_part	denotes	IL-1	http://purl.org/sig/ont/fma/fma86583
T103	620-628	Body_part	denotes	cytokine	http://purl.org/sig/ont/fma/fma84050

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T41	387-396	Body_part	denotes	capillary	http://purl.obolibrary.org/obo/UBERON_0001982

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T368	387-410	Disease	denotes	capillary leak syndrome	http://purl.obolibrary.org/obo/MONDO_0001956
T369	447-450	Disease	denotes	KSS	http://purl.obolibrary.org/obo/MONDO_0010787
T370	706-714	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T231	66-67	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T123	92-100	Chemical	denotes	steroids	http://purl.obolibrary.org/obo/CHEBI_35341
T124	169-177	Chemical	denotes	steroids	http://purl.obolibrary.org/obo/CHEBI_35341
T125	498-500	Chemical	denotes	IL	http://purl.obolibrary.org/obo/CHEBI_63895\|http://purl.obolibrary.org/obo/CHEBI_74072
T127	561-569	Chemical	denotes	steroids	http://purl.obolibrary.org/obo/CHEBI_35341

Id	Subject	Object	Predicate	Lexical cue	hp_id
T179	387-401	Phenotype	denotes	capillary leak	http://purl.obolibrary.org/obo/HP_0030005

Id	Subject	Object	Predicate	Lexical cue
T184	0-110	Sentence	denotes	To our knowledge, the majority of patients with PeCOHS respond to a variable combination of steroids and IVIG.
T185	111-340	Sentence	denotes	The discussion about the immunomodulatory effects of both steroids and IVIG is beyond the scope of this review, but it is interesting to highlight that one of the many effects of IVIG is the down modulation of superantigens [80].
T186	341-467	Sentence	denotes	Of note, IVIG is the therapy of choice in the capillary leak syndrome, whose main features are similar to KSS and PeCOHS [81].
T187	468-742	Sentence	denotes	Finally, the efficacy of anti-IL-1 treatment as “rescue therapy” for cases resistant to IVIG+steroids points out the relevance of this pro-inflammatory cytokine in the hyperinflammatory state, similar to what already shown in adults with COVID-19 and hyperinflammation [82].

Id	Subject	Object	Predicate	Lexical cue
T406	92-100	CHEBI:35341;CHEBI:35341	denotes	steroids
T407	105-109	CHEBI:42098;CHEBI:42098	denotes	IVIG
T408	169-177	CHEBI:35341;CHEBI:35341	denotes	steroids
T409	182-186	CHEBI:42098;CHEBI:42098	denotes	IVIG
T410	290-294	CHEBI:42098;CHEBI:42098	denotes	IVIG
T411	350-354	CHEBI:42098;CHEBI:42098	denotes	IVIG
T412	387-396	UBERON:0001982	denotes	capillary
T413	556-560	CHEBI:42098;CHEBI:42098	denotes	IVIG
T414	561-569	CHEBI:35341;CHEBI:35341	denotes	steroids
T415	694-700	UBERON:0007023	denotes	adults
T416	706-714	SP_7	denotes	COVID-19
T26559	92-100	CHEBI:35341;CHEBI:35341	denotes	steroids
T64521	105-109	CHEBI:42098;CHEBI:42098	denotes	IVIG
T75793	169-177	CHEBI:35341;CHEBI:35341	denotes	steroids
T52297	182-186	CHEBI:42098;CHEBI:42098	denotes	IVIG
T17659	290-294	CHEBI:42098;CHEBI:42098	denotes	IVIG
T68482	350-354	CHEBI:42098;CHEBI:42098	denotes	IVIG
T48537	387-396	UBERON:0001982	denotes	capillary
T9746	556-560	CHEBI:42098;CHEBI:42098	denotes	IVIG
T39797	561-569	CHEBI:35341;CHEBI:35341	denotes	steroids
T11659	694-700	UBERON:0007023	denotes	adults
T84045	706-714	SP_7	denotes	COVID-19

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
974	498-502	Gene	denotes	IL-1	Gene:3552
975	34-42	Species	denotes	patients	Tax:9606
976	92-100	Chemical	denotes	steroids	MESH:D013256
977	169-177	Chemical	denotes	steroids	MESH:D013256
978	447-450	Chemical	denotes	KSS
979	561-569	Chemical	denotes	steroids	MESH:D013256
980	387-410	Disease	denotes	capillary leak syndrome	MESH:D019559
981	706-714	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue
32535093-31073478-4828882	463-465	31073478	denotes	81