PMC:7283670 / 65779-67381 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7283670","sourcedb":"PMC","sourceid":"7283670","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7283670","text":"The efficacy and safety of thalidomide combined with low‐dose hormones in the treatment of Severe COVID‐19 Placebo, drug: thalidomide COVID‐19 thalidomide 40, all, 18 years and older Treatment Placebo comparator: control group α‐interferon: nebulized inhalation, 5 million U or equivalent dose added 2 ml of sterile water for injection, 2 times a day, for 7 days; abidol, 200 mg/time, 3 times a day, for 7 days; methylprednisolone: 40 mg, q12h, for 5 days. placebo: 100 mg/d, qn, for 14 days\nExperimental: thalidomide group α‐interferon: nebulized inhalation, 5 million U or equivalent dose added 2 ml of sterile water for injection, 2 times a day, for 7 days; abidol, 200 mg/time, 3 times a day, for 7 days; methylprednisolone: 40 mg, q12h, for 5 days. thalidomide: 100 mg/d qn for 14 days II Primary (up to 28 days): time to clinical improvement\nSecondary (up to 28 days): clinical status (days 7, 14, 21, and 28), time to hospital discharge or NEWS2 (National Early Warning Score 2) of ≤2 maintained for 24 hr, all cause mortality, duration (days) of mechanical ventilation, duration (days) of extracorporeal membrane oxygenation, duration (days) of supplemental oxygenation, length of hospital stay (days), time to 2019‐nCoV RT‐PCR, change (reduction) in 2019‐nCoV viral load in upper and lower respiratory tract specimens as assessed by area under viral load curve, frequency of serious adverse drug events, Serum TNF‐α, IL‐1β, IL‐2, IL‐6, IL‐7, IL‐10, GSCF, IP10#MCP1, MIP1α, and other cytokine expression levels before and after treatment NCT04273581/Not yet recruiting, Feb18‐May30 2020","divisions":[{"label":"td","span":{"begin":0,"end":106}},{"label":"td","span":{"begin":108,"end":134}},{"label":"td","span":{"begin":136,"end":156}},{"label":"td","span":{"begin":158,"end":185}},{"label":"td","span":{"begin":187,"end":196}},{"label":"td","span":{"begin":198,"end":795}},{"label":"p","span":{"begin":198,"end":496}},{"label":"p","span":{"begin":497,"end":795}},{"label":"td","span":{"begin":797,"end":799}},{"label":"td","span":{"begin":801,"end":1552}},{"label":"p","span":{"begin":801,"end":854}},{"label":"p","span":{"begin":855,"end":1552}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T228","span":{"begin":62,"end":70},"obj":"Body_part"},{"id":"T229","span":{"begin":1300,"end":1323},"obj":"Body_part"},{"id":"T230","span":{"begin":1420,"end":1425},"obj":"Body_part"},{"id":"T231","span":{"begin":1433,"end":1437},"obj":"Body_part"},{"id":"T232","span":{"begin":1440,"end":1444},"obj":"Body_part"},{"id":"T233","span":{"begin":1499,"end":1507},"obj":"Body_part"}],"attributes":[{"id":"A228","pred":"fma_id","subj":"T228","obj":"http://purl.org/sig/ont/fma/fma12278"},{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A232","pred":"fma_id","subj":"T232","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A233","pred":"fma_id","subj":"T233","obj":"http://purl.org/sig/ont/fma/fma84050"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T149","span":{"begin":1300,"end":1323},"obj":"Body_part"},{"id":"T150","span":{"begin":1306,"end":1323},"obj":"Body_part"},{"id":"T151","span":{"begin":1420,"end":1425},"obj":"Body_part"}],"attributes":[{"id":"A149","pred":"uberon_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A151","pred":"uberon_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T375","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"T376","span":{"begin":136,"end":144},"obj":"Disease"},{"id":"T377","span":{"begin":313,"end":320},"obj":"Disease"},{"id":"T378","span":{"begin":610,"end":617},"obj":"Disease"}],"attributes":[{"id":"A375","pred":"mondo_id","subj":"T375","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A376","pred":"mondo_id","subj":"T376","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A377","pred":"mondo_id","subj":"T377","obj":"http://purl.obolibrary.org/obo/MONDO_0005047"},{"id":"A378","pred":"mondo_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/MONDO_0005047"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T591","span":{"begin":167,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T592","span":{"begin":350,"end":351},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T593","span":{"begin":398,"end":399},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T594","span":{"begin":647,"end":648},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T595","span":{"begin":695,"end":696},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T596","span":{"begin":1119,"end":1127},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T597","span":{"begin":1300,"end":1323},"obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"T598","span":{"begin":1440,"end":1444},"obj":"http://purl.obolibrary.org/obo/PR_000001379"}],"attributes":[{"subj":"T591","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T592","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T593","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T594","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T595","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T596","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T597","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T598","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T191","span":{"begin":27,"end":38},"obj":"Chemical"},{"id":"T192","span":{"begin":62,"end":70},"obj":"Chemical"},{"id":"T193","span":{"begin":117,"end":121},"obj":"Chemical"},{"id":"T194","span":{"begin":123,"end":134},"obj":"Chemical"},{"id":"T195","span":{"begin":145,"end":156},"obj":"Chemical"},{"id":"T196","span":{"begin":226,"end":231},"obj":"Chemical"},{"id":"T197","span":{"begin":234,"end":244},"obj":"Chemical"},{"id":"T198","span":{"begin":321,"end":326},"obj":"Chemical"},{"id":"T199","span":{"begin":417,"end":435},"obj":"Chemical"},{"id":"T200","span":{"begin":511,"end":522},"obj":"Chemical"},{"id":"T201","span":{"begin":523,"end":528},"obj":"Chemical"},{"id":"T202","span":{"begin":531,"end":541},"obj":"Chemical"},{"id":"T203","span":{"begin":618,"end":623},"obj":"Chemical"},{"id":"T204","span":{"begin":714,"end":732},"obj":"Chemical"},{"id":"T205","span":{"begin":759,"end":770},"obj":"Chemical"},{"id":"T206","span":{"begin":797,"end":799},"obj":"Chemical"},{"id":"T207","span":{"begin":1407,"end":1411},"obj":"Chemical"},{"id":"T208","span":{"begin":1433,"end":1435},"obj":"Chemical"},{"id":"T210","span":{"begin":1440,"end":1442},"obj":"Chemical"},{"id":"T212","span":{"begin":1446,"end":1448},"obj":"Chemical"},{"id":"T214","span":{"begin":1452,"end":1454},"obj":"Chemical"},{"id":"T216","span":{"begin":1458,"end":1460},"obj":"Chemical"}],"attributes":[{"id":"A191","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_9513"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_9513"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_9513"},{"id":"A196","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A197","pred":"chebi_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_9513"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_9513"},{"id":"A206","pred":"chebi_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A209","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A211","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A212","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A213","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A215","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A217","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T197","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T198","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T199","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T200","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T210","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T651","span":{"begin":0,"end":436},"obj":"Sentence"},{"id":"T652","span":{"begin":437,"end":470},"obj":"Sentence"},{"id":"T653","span":{"begin":471,"end":496},"obj":"Sentence"},{"id":"T654","span":{"begin":497,"end":733},"obj":"Sentence"},{"id":"T655","span":{"begin":734,"end":771},"obj":"Sentence"},{"id":"T656","span":{"begin":772,"end":854},"obj":"Sentence"},{"id":"T657","span":{"begin":855,"end":1602},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T651","pred":"source","obj":"LitCovid-sentences"},{"subj":"T652","pred":"source","obj":"LitCovid-sentences"},{"subj":"T653","pred":"source","obj":"LitCovid-sentences"},{"subj":"T654","pred":"source","obj":"LitCovid-sentences"},{"subj":"T655","pred":"source","obj":"LitCovid-sentences"},{"subj":"T656","pred":"source","obj":"LitCovid-sentences"},{"subj":"T657","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1833","span":{"begin":1426,"end":1431},"obj":"Gene"},{"id":"1834","span":{"begin":1433,"end":1438},"obj":"Gene"},{"id":"1835","span":{"begin":1440,"end":1444},"obj":"Gene"},{"id":"1836","span":{"begin":1446,"end":1450},"obj":"Gene"},{"id":"1837","span":{"begin":1452,"end":1456},"obj":"Gene"},{"id":"1838","span":{"begin":1458,"end":1463},"obj":"Gene"},{"id":"1839","span":{"begin":1471,"end":1475},"obj":"Gene"},{"id":"1840","span":{"begin":1476,"end":1480},"obj":"Gene"},{"id":"1841","span":{"begin":1482,"end":1487},"obj":"Gene"},{"id":"1903","span":{"begin":1226,"end":1235},"obj":"Species"},{"id":"1904","span":{"begin":1266,"end":1275},"obj":"Species"},{"id":"2068","span":{"begin":321,"end":326},"obj":"Chemical"},{"id":"2069","span":{"begin":511,"end":522},"obj":"Chemical"},{"id":"2070","span":{"begin":618,"end":623},"obj":"Chemical"},{"id":"2071","span":{"begin":666,"end":672},"obj":"Chemical"},{"id":"2072","span":{"begin":714,"end":732},"obj":"Chemical"}],"attributes":[{"id":"A1833","pred":"tao:has_database_id","subj":"1833","obj":"Gene:7124"},{"id":"A1834","pred":"tao:has_database_id","subj":"1834","obj":"Gene:3552"},{"id":"A1835","pred":"tao:has_database_id","subj":"1835","obj":"Gene:3558"},{"id":"A1836","pred":"tao:has_database_id","subj":"1836","obj":"Gene:3569"},{"id":"A1837","pred":"tao:has_database_id","subj":"1837","obj":"Gene:3574"},{"id":"A1838","pred":"tao:has_database_id","subj":"1838","obj":"Gene:3586"},{"id":"A1839","pred":"tao:has_database_id","subj":"1839","obj":"Gene:3627"},{"id":"A1840","pred":"tao:has_database_id","subj":"1840","obj":"Gene:6347"},{"id":"A1841","pred":"tao:has_database_id","subj":"1841","obj":"Gene:6348"},{"id":"A1903","pred":"tao:has_database_id","subj":"1903","obj":"Tax:2697049"},{"id":"A1904","pred":"tao:has_database_id","subj":"1904","obj":"Tax:2697049"},{"id":"A2068","pred":"tao:has_database_id","subj":"2068","obj":"MESH:D014867"},{"id":"A2069","pred":"tao:has_database_id","subj":"2069","obj":"MESH:D013792"},{"id":"A2070","pred":"tao:has_database_id","subj":"2070","obj":"MESH:D014867"},{"id":"A2072","pred":"tao:has_database_id","subj":"2072","obj":"MESH:D008775"},{"subj":"1833","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1834","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1835","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1836","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1837","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1838","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1839","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1840","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1841","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1903","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1904","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2068","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2069","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2070","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2071","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2072","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecbe93","default":true},{"id":"LitCovid-PD-UBERON","color":"#a493ec"},{"id":"LitCovid-PD-MONDO","color":"#9bec93"},{"id":"LitCovid-PD-CLO","color":"#ec93b5"},{"id":"LitCovid-PD-CHEBI","color":"#93cfec"},{"id":"LitCovid-sentences","color":"#eaec93"},{"id":"LitCovid-PubTator","color":"#d493ec"}]}]}}