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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T70121","span":{"begin":236,"end":240},"obj":"Body_part"},{"id":"T2202","span":{"begin":775,"end":783},"obj":"Body_part"},{"id":"T61701","span":{"begin":946,"end":951},"obj":"Body_part"},{"id":"T62000","span":{"begin":999,"end":1004},"obj":"Body_part"},{"id":"T60996","span":{"begin":1090,"end":1096},"obj":"Body_part"},{"id":"T83591","span":{"begin":1259,"end":1264},"obj":"Body_part"},{"id":"T9472","span":{"begin":2024,"end":2029},"obj":"Body_part"},{"id":"T33287","span":{"begin":2384,"end":2390},"obj":"Body_part"},{"id":"T63692","span":{"begin":2587,"end":2592},"obj":"Body_part"},{"id":"T43858","span":{"begin":2778,"end":2783},"obj":"Body_part"}],"attributes":[{"id":"A61746","pred":"fma_id","subj":"T70121","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A77271","pred":"fma_id","subj":"T2202","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A92128","pred":"fma_id","subj":"T61701","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A83601","pred":"fma_id","subj":"T62000","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A33714","pred":"fma_id","subj":"T60996","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A48680","pred":"fma_id","subj":"T83591","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A57652","pred":"fma_id","subj":"T9472","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A62610","pred":"fma_id","subj":"T33287","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A64473","pred":"fma_id","subj":"T63692","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A18651","pred":"fma_id","subj":"T43858","obj":"http://purl.org/sig/ont/fma/fma67498"}],"text":"5.1 Clinical symptom spectrum\nUnderstanding the otherwise nonspecific clinical signs and symptoms of COVID‐19 is a crucial step toward appropriate management of the disease. Patients mostly complain of fever, non‐productive cough, and body ache or extreme tiredness. In some cases, diarrhea and nausea precede fever by a few days, suggesting that fever might not be the initial manifestation of infection. A small number of patients reportedly had headache, or even developed hemoptysis (Guan et al., 2020; Wang, Hu, et al., 2020). Some patients remained asymptomatic, despite being tested positive for the disease (Chan et al., 2020). According to several studies, infection with SARS‐CoV‐2 in the elderly, especially the male community, is more likely to result in severe alveolar damage and respiratory failure (Chen, Zhou, et al., 2020). Occasionally, the disease may be demonstrated with a fulminant natural history, rapidly progressing to organ dysfunction, and even death in critical cases. Organ dysfunction includes conditions such as shock, ARDS, acute cardiac injury, and acute kidney injury (Huang et al., 2020; Wang, Hu, et al., 2020). From a laboratory point of view, lymphopenia, thrombocytopenia, impaired prothrombin time (PT), and elevated serum levels of CRP stand among the findings that can be reported for patients with COVID‐19 (Chen, Zhou, et al., 2020; Guan et al., 2020; Huang et al., 2020; Wang, Hu, et al., 2020). Overall, any patient with fever and acute respiratory symptoms, who is reported to have lymphopenia or leukopenia on lab examination, should be suspected. A history of travel to Wuhan or having close contact with local residents is a strong indicator for careful management of the patient (Zu et al., 2020). Table 2 represents the criteria for diagnosis of COVID‐19 infected patients (Committee, 2020b; Zu et al., 2020; WWW.ClinicalTrials.gov).\nTable 2 Criteria for clinical severity of confirmed COVID‐19 pneumonia\nPatient Clinical findings CT (imaging findings of pneumonia) Organ damage\nMild Negative None None\nNo dyspnea, with or without cough, fever \u003c38°C (quelled without treatment)\nNo history of chronic respiratory disease\nModerate dyspnea, with or without cough Multifocal patchy GGOs with subpleural distribution None\nSpO2 \u003e93% without oxygen inhalation\nSevere Fever Diffuse heterogeneous consolidation with GGO, None\nMuscle ache Rapid progression (\u003e50%) on CT imaging within 24–48 hr\nHeadache\nConfusion\nRespiratory distress:\nRR ≥ 30 times/min\nSpO2 \u003c 93% at rest\nPaO2/FiO2 ≤ 300 mmHg\nCritical Shock “Extra pulmonary” organ failure or MODS\nRespiratory failure\nneed mechanical assistance\nIntensive care unit is needed\nAbbreviations: FiO2, fraction of inspired oxygen; GGO, ground‐glass opacity; MODS, multiple organ dysfunction syndrome; PaO2, partial pressure of oxygen; RR, respiratory rate, SpO2, oxygen saturation.\nJohn Wiley \u0026 Sons, Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T50","span":{"begin":946,"end":951},"obj":"Body_part"},{"id":"T51","span":{"begin":999,"end":1004},"obj":"Body_part"},{"id":"T52","span":{"begin":1090,"end":1096},"obj":"Body_part"},{"id":"T53","span":{"begin":1259,"end":1264},"obj":"Body_part"},{"id":"T54","span":{"begin":2024,"end":2029},"obj":"Body_part"},{"id":"T55","span":{"begin":2587,"end":2592},"obj":"Body_part"},{"id":"T56","span":{"begin":2778,"end":2783},"obj":"Body_part"}],"attributes":[{"id":"A50","pred":"uberon_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"5.1 Clinical symptom spectrum\nUnderstanding the otherwise nonspecific clinical signs and symptoms of COVID‐19 is a crucial step toward appropriate management of the disease. Patients mostly complain of fever, non‐productive cough, and body ache or extreme tiredness. In some cases, diarrhea and nausea precede fever by a few days, suggesting that fever might not be the initial manifestation of infection. A small number of patients reportedly had headache, or even developed hemoptysis (Guan et al., 2020; Wang, Hu, et al., 2020). Some patients remained asymptomatic, despite being tested positive for the disease (Chan et al., 2020). According to several studies, infection with SARS‐CoV‐2 in the elderly, especially the male community, is more likely to result in severe alveolar damage and respiratory failure (Chen, Zhou, et al., 2020). Occasionally, the disease may be demonstrated with a fulminant natural history, rapidly progressing to organ dysfunction, and even death in critical cases. Organ dysfunction includes conditions such as shock, ARDS, acute cardiac injury, and acute kidney injury (Huang et al., 2020; Wang, Hu, et al., 2020). From a laboratory point of view, lymphopenia, thrombocytopenia, impaired prothrombin time (PT), and elevated serum levels of CRP stand among the findings that can be reported for patients with COVID‐19 (Chen, Zhou, et al., 2020; Guan et al., 2020; Huang et al., 2020; Wang, Hu, et al., 2020). Overall, any patient with fever and acute respiratory symptoms, who is reported to have lymphopenia or leukopenia on lab examination, should be suspected. A history of travel to Wuhan or having close contact with local residents is a strong indicator for careful management of the patient (Zu et al., 2020). Table 2 represents the criteria for diagnosis of COVID‐19 infected patients (Committee, 2020b; Zu et al., 2020; WWW.ClinicalTrials.gov).\nTable 2 Criteria for clinical severity of confirmed COVID‐19 pneumonia\nPatient Clinical findings CT (imaging findings of pneumonia) Organ damage\nMild Negative None None\nNo dyspnea, with or without cough, fever \u003c38°C (quelled without treatment)\nNo history of chronic respiratory disease\nModerate dyspnea, with or without cough Multifocal patchy GGOs with subpleural distribution None\nSpO2 \u003e93% without oxygen inhalation\nSevere Fever Diffuse heterogeneous consolidation with GGO, None\nMuscle ache Rapid progression (\u003e50%) on CT imaging within 24–48 hr\nHeadache\nConfusion\nRespiratory distress:\nRR ≥ 30 times/min\nSpO2 \u003c 93% at rest\nPaO2/FiO2 ≤ 300 mmHg\nCritical Shock “Extra pulmonary” organ failure or MODS\nRespiratory failure\nneed mechanical assistance\nIntensive care unit is needed\nAbbreviations: FiO2, fraction of inspired oxygen; GGO, ground‐glass opacity; MODS, multiple organ dysfunction syndrome; PaO2, partial pressure of oxygen; RR, respiratory rate, SpO2, oxygen saturation.\nJohn Wiley \u0026 Sons, Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T56","span":{"begin":724,"end":728},"obj":"Chemical"},{"id":"T57","span":{"begin":1241,"end":1243},"obj":"Chemical"},{"id":"T58","span":{"begin":1684,"end":1693},"obj":"Chemical"},{"id":"T59","span":{"begin":2299,"end":2305},"obj":"Chemical"},{"id":"T60","span":{"begin":2493,"end":2495},"obj":"Chemical"},{"id":"T61","span":{"begin":2728,"end":2734},"obj":"Chemical"},{"id":"T62","span":{"begin":2832,"end":2838},"obj":"Chemical"},{"id":"T63","span":{"begin":2840,"end":2842},"obj":"Chemical"},{"id":"T64","span":{"begin":2868,"end":2874},"obj":"Chemical"}],"attributes":[{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_141395"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_47867"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_73811"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_73811"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"5.1 Clinical symptom spectrum\nUnderstanding the otherwise nonspecific clinical signs and symptoms of COVID‐19 is a crucial step toward appropriate management of the disease. Patients mostly complain of fever, non‐productive cough, and body ache or extreme tiredness. In some cases, diarrhea and nausea precede fever by a few days, suggesting that fever might not be the initial manifestation of infection. A small number of patients reportedly had headache, or even developed hemoptysis (Guan et al., 2020; Wang, Hu, et al., 2020). Some patients remained asymptomatic, despite being tested positive for the disease (Chan et al., 2020). According to several studies, infection with SARS‐CoV‐2 in the elderly, especially the male community, is more likely to result in severe alveolar damage and respiratory failure (Chen, Zhou, et al., 2020). Occasionally, the disease may be demonstrated with a fulminant natural history, rapidly progressing to organ dysfunction, and even death in critical cases. Organ dysfunction includes conditions such as shock, ARDS, acute cardiac injury, and acute kidney injury (Huang et al., 2020; Wang, Hu, et al., 2020). From a laboratory point of view, lymphopenia, thrombocytopenia, impaired prothrombin time (PT), and elevated serum levels of CRP stand among the findings that can be reported for patients with COVID‐19 (Chen, Zhou, et al., 2020; Guan et al., 2020; Huang et al., 2020; Wang, Hu, et al., 2020). Overall, any patient with fever and acute respiratory symptoms, who is reported to have lymphopenia or leukopenia on lab examination, should be suspected. A history of travel to Wuhan or having close contact with local residents is a strong indicator for careful management of the patient (Zu et al., 2020). Table 2 represents the criteria for diagnosis of COVID‐19 infected patients (Committee, 2020b; Zu et al., 2020; WWW.ClinicalTrials.gov).\nTable 2 Criteria for clinical severity of confirmed COVID‐19 pneumonia\nPatient Clinical findings CT (imaging findings of pneumonia) Organ damage\nMild Negative None None\nNo dyspnea, with or without cough, fever \u003c38°C (quelled without treatment)\nNo history of chronic respiratory disease\nModerate dyspnea, with or without cough Multifocal patchy GGOs with subpleural distribution None\nSpO2 \u003e93% without oxygen inhalation\nSevere Fever Diffuse heterogeneous consolidation with GGO, None\nMuscle ache Rapid progression (\u003e50%) on CT imaging within 24–48 hr\nHeadache\nConfusion\nRespiratory distress:\nRR ≥ 30 times/min\nSpO2 \u003c 93% at rest\nPaO2/FiO2 ≤ 300 mmHg\nCritical Shock “Extra pulmonary” organ failure or MODS\nRespiratory failure\nneed mechanical assistance\nIntensive care unit is needed\nAbbreviations: FiO2, fraction of inspired oxygen; GGO, ground‐glass opacity; MODS, multiple organ dysfunction syndrome; PaO2, partial pressure of oxygen; RR, respiratory rate, SpO2, oxygen saturation.\nJohn Wiley \u0026 Sons, Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency."}

LitCovid-sentences

LitCovid-PD-HP

LitCovid-PubTator

PMC:7283670 / 25967-29185 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7283670 / 25967-29185 JSON TXT