PMC:7283670 / 14326-15341 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7283670","sourcedb":"PMC","sourceid":"7283670","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7283670","text":"An essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, \u0026 Simões e Silva, 2008). Upon infection, SARS‐CoV‐2 binds ACE2. This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. The final effect of ACE2 in an otherwise healthy adult is to increase reabsorption of sodium and the reciprocal excretion of potassium ions (K+). The concomitant re‐uptake of water with sodium reabsorption prompts an increase in blood pressure (Weir \u0026 Rolfe, 2010). Potassium is the predominant intracellular ion, that is majorly involved in regulation of cell membrane polarity. Too low levels of K+ in blood, known as hypokalemia, can result in cellular hyper‐polarity. A hyper‐polarized cell membrane tends to be depolarized faster than normal, causing aberrancy in the function of cardiac cells (Bielecka‐Dabrowa et al., 2012).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T45844","span":{"begin":62,"end":67},"obj":"Body_part"},{"id":"T65421","span":{"begin":139,"end":142},"obj":"Body_part"},{"id":"T45087","span":{"begin":150,"end":154},"obj":"Body_part"},{"id":"T88598","span":{"begin":613,"end":618},"obj":"Body_part"},{"id":"T47809","span":{"begin":740,"end":753},"obj":"Body_part"},{"id":"T61144","span":{"begin":740,"end":744},"obj":"Body_part"},{"id":"T3455","span":{"begin":788,"end":793},"obj":"Body_part"},{"id":"T95222","span":{"begin":874,"end":887},"obj":"Body_part"},{"id":"T6739","span":{"begin":874,"end":878},"obj":"Body_part"},{"id":"T24435","span":{"begin":977,"end":982},"obj":"Body_part"}],"attributes":[{"id":"A6881","pred":"fma_id","subj":"T45844","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A79515","pred":"fma_id","subj":"T65421","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A67556","pred":"fma_id","subj":"T45087","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A14032","pred":"fma_id","subj":"T88598","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A29365","pred":"fma_id","subj":"T47809","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A18873","pred":"fma_id","subj":"T61144","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A46049","pred":"fma_id","subj":"T3455","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A99774","pred":"fma_id","subj":"T95222","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A43324","pred":"fma_id","subj":"T6739","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34149","pred":"fma_id","subj":"T24435","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T45844","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T65421","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T45087","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T88598","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T47809","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T61144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3455","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T95222","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6739","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24435","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T24","span":{"begin":62,"end":67},"obj":"Body_part"},{"id":"T25","span":{"begin":139,"end":142},"obj":"Body_part"},{"id":"T26","span":{"begin":613,"end":618},"obj":"Body_part"},{"id":"T27","span":{"begin":788,"end":793},"obj":"Body_part"}],"attributes":[{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":250,"end":259},"obj":"Disease"},{"id":"T73","span":{"begin":261,"end":265},"obj":"Disease"},{"id":"T74","span":{"begin":601,"end":627},"obj":"Disease"},{"id":"T75","span":{"begin":804,"end":815},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0003019"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T99674","span":{"begin":62,"end":67},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T84772","span":{"begin":62,"end":67},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T30692","span":{"begin":139,"end":142},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T15067","span":{"begin":613,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T63295","span":{"begin":613,"end":618},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T19778","span":{"begin":740,"end":744},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T98378","span":{"begin":745,"end":753},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T76879","span":{"begin":788,"end":793},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T41190","span":{"begin":788,"end":793},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T91219","span":{"begin":856,"end":857},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T48010","span":{"begin":874,"end":878},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T44827","span":{"begin":879,"end":887},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T6950","span":{"begin":977,"end":982},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T99674","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84772","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30692","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15067","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63295","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19778","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T98378","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T76879","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41190","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91219","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48010","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44827","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6950","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22","span":{"begin":164,"end":175},"obj":"Chemical"},{"id":"T23","span":{"begin":176,"end":187},"obj":"Chemical"},{"id":"T25","span":{"begin":470,"end":476},"obj":"Chemical"},{"id":"T26","span":{"begin":509,"end":518},"obj":"Chemical"},{"id":"T27","span":{"begin":519,"end":523},"obj":"Chemical"},{"id":"T28","span":{"begin":559,"end":564},"obj":"Chemical"},{"id":"T29","span":{"begin":570,"end":576},"obj":"Chemical"},{"id":"T30","span":{"begin":693,"end":696},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A24","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_26216"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T94048","span":{"begin":300,"end":311},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T48643","span":{"begin":496,"end":505},"obj":"http://purl.obolibrary.org/obo/GO_0007588"},{"id":"T8749","span":{"begin":549,"end":555},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T39000","span":{"begin":549,"end":555},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T87922","span":{"begin":726,"end":736},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"attributes":[{"subj":"T94048","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T48643","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8749","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T39000","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T87922","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T110","span":{"begin":0,"end":244},"obj":"Sentence"},{"id":"T111","span":{"begin":245,"end":283},"obj":"Sentence"},{"id":"T112","span":{"begin":284,"end":383},"obj":"Sentence"},{"id":"T113","span":{"begin":384,"end":529},"obj":"Sentence"},{"id":"T114","span":{"begin":530,"end":649},"obj":"Sentence"},{"id":"T115","span":{"begin":650,"end":763},"obj":"Sentence"},{"id":"T116","span":{"begin":764,"end":855},"obj":"Sentence"},{"id":"T117","span":{"begin":856,"end":1015},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"},{"subj":"T112","pred":"source","obj":"LitCovid-sentences"},{"subj":"T113","pred":"source","obj":"LitCovid-sentences"},{"subj":"T114","pred":"source","obj":"LitCovid-sentences"},{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"},{"subj":"T117","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":601,"end":627},"obj":"Phenotype"},{"id":"T16","span":{"begin":804,"end":815},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0032263"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002900"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"294","span":{"begin":78,"end":82},"obj":"Gene"},{"id":"295","span":{"begin":278,"end":282},"obj":"Gene"},{"id":"296","span":{"begin":315,"end":319},"obj":"Gene"},{"id":"297","span":{"begin":370,"end":374},"obj":"Gene"},{"id":"298","span":{"begin":404,"end":408},"obj":"Gene"},{"id":"299","span":{"begin":261,"end":271},"obj":"Species"},{"id":"300","span":{"begin":176,"end":187},"obj":"Chemical"},{"id":"301","span":{"begin":470,"end":476},"obj":"Chemical"},{"id":"302","span":{"begin":509,"end":518},"obj":"Chemical"},{"id":"303","span":{"begin":559,"end":564},"obj":"Chemical"},{"id":"304","span":{"begin":570,"end":576},"obj":"Chemical"},{"id":"305","span":{"begin":650,"end":659},"obj":"Chemical"},{"id":"306","span":{"begin":250,"end":259},"obj":"Disease"},{"id":"307","span":{"begin":804,"end":815},"obj":"Disease"}],"attributes":[{"id":"A294","pred":"tao:has_database_id","subj":"294","obj":"Gene:59272"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"Gene:59272"},{"id":"A296","pred":"tao:has_database_id","subj":"296","obj":"Gene:59272"},{"id":"A297","pred":"tao:has_database_id","subj":"297","obj":"Gene:59272"},{"id":"A298","pred":"tao:has_database_id","subj":"298","obj":"Gene:59272"},{"id":"A299","pred":"tao:has_database_id","subj":"299","obj":"Tax:2697049"},{"id":"A300","pred":"tao:has_database_id","subj":"300","obj":"MESH:D000450"},{"id":"A301","pred":"tao:has_database_id","subj":"301","obj":"MESH:D012964"},{"id":"A302","pred":"tao:has_database_id","subj":"302","obj":"MESH:D011188"},{"id":"A303","pred":"tao:has_database_id","subj":"303","obj":"MESH:D014867"},{"id":"A304","pred":"tao:has_database_id","subj":"304","obj":"MESH:D012964"},{"id":"A305","pred":"tao:has_database_id","subj":"305","obj":"MESH:D011188"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"MESH:D007239"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"MESH:D007008"},{"subj":"294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"295","pred":"source","obj":"LitCovid-PubTator"},{"subj":"296","pred":"source","obj":"LitCovid-PubTator"},{"subj":"297","pred":"source","obj":"LitCovid-PubTator"},{"subj":"298","pred":"source","obj":"LitCovid-PubTator"},{"subj":"299","pred":"source","obj":"LitCovid-PubTator"},{"subj":"300","pred":"source","obj":"LitCovid-PubTator"},{"subj":"301","pred":"source","obj":"LitCovid-PubTator"},{"subj":"302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"305","pred":"source","obj":"LitCovid-PubTator"},{"subj":"306","pred":"source","obj":"LitCovid-PubTator"},{"subj":"307","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#c793ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#93ecad"},{"id":"LitCovid-PD-MONDO","color":"#ec9393"},{"id":"LitCovid-PD-CLO","color":"#93acec"},{"id":"LitCovid-PD-CHEBI","color":"#c6ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93e1"},{"id":"LitCovid-sentences","color":"#93ecdd"},{"id":"LitCovid-PD-HP","color":"#ecc393"},{"id":"LitCovid-PubTator","color":"#a993ec"}]}]}}