PMC:7283670 / 14326-15341
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T45844 | 62-67 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T65421 | 139-142 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T45087 | 150-154 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T88598 | 613-618 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T47809 | 740-753 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T61144 | 740-744 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T3455 | 788-793 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T95222 | 874-887 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T6739 | 874-878 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T24435 | 977-982 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T24 | 62-67 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T25 | 139-142 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T26 | 613-618 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T27 | 788-793 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T72 | 250-259 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T73 | 261-265 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T74 | 601-627 | Disease | denotes | increase in blood pressure | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T75 | 804-815 | Disease | denotes | hypokalemia | http://purl.obolibrary.org/obo/MONDO_0003019 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T99674 | 62-67 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T84772 | 62-67 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T30692 | 139-142 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T15067 | 613-618 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T63295 | 613-618 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T19778 | 740-744 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T98378 | 745-753 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T76879 | 788-793 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T41190 | 788-793 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T91219 | 856-857 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T48010 | 874-878 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T44827 | 879-887 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T6950 | 977-982 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T22 | 164-175 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T23 | 176-187 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T25 | 470-476 | Chemical | denotes | sodium | http://purl.obolibrary.org/obo/CHEBI_26708 |
| T26 | 509-518 | Chemical | denotes | potassium | http://purl.obolibrary.org/obo/CHEBI_26216 |
| T27 | 519-523 | Chemical | denotes | ions | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T28 | 559-564 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T29 | 570-576 | Chemical | denotes | sodium | http://purl.obolibrary.org/obo/CHEBI_26708 |
| T30 | 693-696 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T94048 | 300-311 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T48643 | 496-505 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
| T8749 | 549-555 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
| T39000 | 549-555 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
| T87922 | 726-736 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T110 | 0-244 | Sentence | denotes | An essential player in maintenance of electrolyte balance and blood pressure, ACE2 is regarded by many as the principal counter‐regulatory arm in the axis of renin–angiotensin‐aldosterone system (RAAS; Santos, Ferreira, & Simões e Silva, 2008). |
| T111 | 245-283 | Sentence | denotes | Upon infection, SARS‐CoV‐2 binds ACE2. |
| T112 | 284-383 | Sentence | denotes | This results in degradation of ACE2, which subsequently dampens the counter‐effect of ACE2 on RAAS. |
| T113 | 384-529 | Sentence | denotes | The final effect of ACE2 in an otherwise healthy adult is to increase reabsorption of sodium and the reciprocal excretion of potassium ions (K+). |
| T114 | 530-649 | Sentence | denotes | The concomitant re‐uptake of water with sodium reabsorption prompts an increase in blood pressure (Weir & Rolfe, 2010). |
| T115 | 650-763 | Sentence | denotes | Potassium is the predominant intracellular ion, that is majorly involved in regulation of cell membrane polarity. |
| T116 | 764-855 | Sentence | denotes | Too low levels of K+ in blood, known as hypokalemia, can result in cellular hyper‐polarity. |
| T117 | 856-1015 | Sentence | denotes | A hyper‐polarized cell membrane tends to be depolarized faster than normal, causing aberrancy in the function of cardiac cells (Bielecka‐Dabrowa et al., 2012). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T15 | 601-627 | Phenotype | denotes | increase in blood pressure | http://purl.obolibrary.org/obo/HP_0032263 |
| T16 | 804-815 | Phenotype | denotes | hypokalemia | http://purl.obolibrary.org/obo/HP_0002900 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 294 | 78-82 | Gene | denotes | ACE2 | Gene:59272 |
| 295 | 278-282 | Gene | denotes | ACE2 | Gene:59272 |
| 296 | 315-319 | Gene | denotes | ACE2 | Gene:59272 |
| 297 | 370-374 | Gene | denotes | ACE2 | Gene:59272 |
| 298 | 404-408 | Gene | denotes | ACE2 | Gene:59272 |
| 299 | 261-271 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
| 300 | 176-187 | Chemical | denotes | aldosterone | MESH:D000450 |
| 301 | 470-476 | Chemical | denotes | sodium | MESH:D012964 |
| 302 | 509-518 | Chemical | denotes | potassium | MESH:D011188 |
| 303 | 559-564 | Chemical | denotes | water | MESH:D014867 |
| 304 | 570-576 | Chemical | denotes | sodium | MESH:D012964 |
| 305 | 650-659 | Chemical | denotes | Potassium | MESH:D011188 |
| 306 | 250-259 | Disease | denotes | infection | MESH:D007239 |
| 307 | 804-815 | Disease | denotes | hypokalemia | MESH:D007008 |