PMC:7283670 / 122509-123599
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T83 | 307-312 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T84 | 680-689 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T85 | 747-751 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T86 | 999-1006 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T232 | 307-312 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T666 | 263-272 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T667 | 452-468 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T669 | 855-859 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T154 | 98-101 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T155 | 307-312 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T156 | 499-502 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T157 | 552-560 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T158 | 659-660 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T159 | 727-732 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T160 | 747-751 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T161 | 882-886 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T162 | 963-973 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T163 | 989-998 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T164 | 1015-1016 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T165 | 1017-1026 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T52426 | 75-86 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T56465 | 87-96 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T21830 | 175-183 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T87346 | 215-226 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T86968 | 227-236 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T49099 | 542-551 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T47561 | 564-575 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T3955 | 576-585 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T238 | 638-642 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T64771 | 753-764 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T240 | 765-774 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T20352 | 981-988 | Chemical | denotes | mitogen | http://purl.obolibrary.org/obo/CHEBI_52290 |
| T35707 | 999-1006 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 452-468 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T15 | 816-829 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T16 | 999-1026 | http://purl.obolibrary.org/obo/GO_0010737 | denotes | protein kinase, a signaling |
| T17 | 1017-1026 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1023 | 0-184 | Sentence | denotes | So far, close monitoring of over 100 patients, who were under treatment of chloroquine phosphate, has provided further evidence regarding the effectiveness of this long‐known medicine. |
| T1024 | 185-389 | Sentence | denotes | Investigations indicated that chloroquine phosphate prevented exacerbation of pneumonia in these patients, improved their chest CT findings, and shortened the otherwise long natural course of the disease. |
| T1025 | 390-495 | Sentence | denotes | Importantly, there have been no records of severe reaction or hypersensitivity to this therapeutic agent. |
| T1026 | 496-938 | Sentence | denotes | It has been suggested that the broad‐spectrum antiviral activity of chloroquine phosphate lies within the complicated pharmacodynamics of the drug that results in a basic shift in the endosomal pH required for successful fusion of virus onto the host cell. chloroquine phosphate also seems to have disruptive effects on glycosylation of cellular receptors of SARS‐CoV (Yin & Wunderink, 2018; Zumla et al., 2020), rendering them nonfunctional. |
| T1027 | 939-1090 | Sentence | denotes | It also interferes with activation of p38 mitogen‐activated protein kinase, a signaling event involved in replication of HCoV‐229E (Kono et al., 2008). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T318 | 263-272 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T319 | 452-468 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2499 | 977-1013 | Gene | denotes | p38 mitogen‐activated protein kinase | Gene:1432 |
| 2500 | 37-45 | Species | denotes | patients | Tax:9606 |
| 2501 | 282-290 | Species | denotes | patients | Tax:9606 |
| 2502 | 855-863 | Species | denotes | SARS‐CoV | Tax:694009 |
| 2503 | 1060-1069 | Species | denotes | HCoV‐229E | Tax:11137 |
| 2504 | 75-96 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 2505 | 215-236 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 2506 | 564-585 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 2507 | 753-774 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 2508 | 263-272 | Disease | denotes | pneumonia | MESH:D011014 |
| 2509 | 452-468 | Disease | denotes | hypersensitivity | MESH:D004342 |