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PMC:7281546 / 54901-57109 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T332 37-45 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T333 52-60 Body_part denotes Proteins http://purl.org/sig/ont/fma/fma67257
T334 207-211 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 323-327 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T336 335-356 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T337 358-360 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T338 430-437 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T339 540-544 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T340 676-678 Body_part denotes ER http://purl.org/sig/ont/fma/fma63842
T341 746-751 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T342 1825-1828 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T343 1943-1946 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 299-308 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T120 908-911 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T511 111-113 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T512 118-120 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T513 118-120 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T514 155-163 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T515 207-211 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T516 323-327 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T517 482-487 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T518 540-544 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T519 632-637 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T520 690-700 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T521 708-709 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T522 746-751 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T523 845-862 http://purl.obolibrary.org/obo/PR_000024990 denotes IFNs and type III
T524 965-966 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T525 1163-1164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T526 1265-1274 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T527 1341-1346 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T528 1417-1418 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T529 1668-1669 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T530 1708-1709 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 1837-1838 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 1856-1860 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3′-5
T533 1878-1886 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T534 1899-1900 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T535 2053-2073 http://purl.obolibrary.org/obo/PR_000024990 denotes IFN and the type III

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T93052 37-45 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T12139 118-120 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T83472 396-406 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T27461 430-437 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5121 580-590 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T63271 704-706 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T43488 867-878 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T25687 1413-1415 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T36475 1476-1486 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T7051 1545-1557 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T70647 1553-1557 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T40947 1962-1972 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T25370 2016-2026 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T67576 2171-2181 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T30 545-563 Phenotype denotes growth retardation http://purl.obolibrary.org/obo/HP_0001510

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T424 155-170 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T425 212-221 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T426 212-221 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T427 251-268 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T428 251-268 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T429 270-283 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T430 312-319 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T431 323-333 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T432 369-378 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T433 380-395 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T434 408-429 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with host
T435 462-477 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T436 482-495 http://purl.obolibrary.org/obo/GO_0046755 denotes virus budding
T437 488-495 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T438 540-551 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T439 545-551 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T440 567-574 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T441 652-659 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T442 755-762 http://purl.obolibrary.org/obo/GO_0051320 denotes S-phase
T443 777-794 http://purl.obolibrary.org/obo/GO_0006900 denotes vesicle formation
T444 785-794 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T445 893-904 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T446 928-943 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T447 948-959 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T448 1118-1135 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T449 1118-1135 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T450 1171-1185 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase
T451 1187-1190 http://purl.obolibrary.org/obo/GO_0004843 denotes DUB
T452 1197-1212 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitinates
T453 1265-1274 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T454 1374-1397 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T455 1676-1693 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T456 1676-1693 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T457 1748-1765 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T458 1748-1765 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T459 1805-1816 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T460 1859-1886 http://purl.obolibrary.org/obo/GO_0008859 denotes 5′ exoribonuclease activity
T461 1862-1886 http://purl.obolibrary.org/obo/GO_0004532 denotes exoribonuclease activity
T462 1913-1928 http://purl.obolibrary.org/obo/GO_0006298 denotes mismatch repair
T463 1943-1956 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T464 1947-1956 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T465 2140-2151 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T419 0-46 Sentence denotes Table 1 The functions of PEDV viral proteins.
T420 47-107 Sentence denotes PEDV Proteins The Biological Processes Involved References
T421 108-247 Sentence denotes S (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]
T422 248-458 Sentence denotes N viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]
T423 459-628 Sentence denotes M virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]
T424 629-726 Sentence denotes E virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]
T425 727-831 Sentence denotes ORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]
T426 832-1058 Sentence denotes nsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]
T427 1059-1072 Sentence denotes nsp2 Unknown
T428 1073-1286 Sentence denotes nsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]
T429 1287-1451 Sentence denotes nsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]
T430 1452-1651 Sentence denotes nsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]
T431 1652-1700 Sentence denotes nsp12 encoding a RdRp; viral replication [134]
T432 1701-1772 Sentence denotes nsp13 a NTPase/helicase that is essential for viral replication [111]
T433 1773-1997 Sentence denotes nsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]
T434 1998-2106 Sentence denotes nsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]
T435 2107-2208 Sentence denotes nsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2552 438-442 Gene denotes NPM1 Gene:4869
2553 576-579 Gene denotes IFN Gene:3439
2554 704-709 Gene denotes NF-κB Gene:4790
2555 727-731 Gene denotes ORF3 Gene:136991
2556 863-866 Gene denotes IFN Gene:3439
2557 908-911 Gene denotes CBP Gene:1387
2558 963-967 Gene denotes IκBα Gene:4792
2559 980-983 Gene denotes p65 Gene:5970
2560 1041-1045 Gene denotes IRF1 Gene:3659
2561 1213-1218 Gene denotes RIG-I Gene:23586
2562 1223-1228 Gene denotes STING Gene:340061
2563 1287-1291 Gene denotes nsp5 Gene:92521
2564 1413-1438 Gene denotes NF-κB essential modulator Gene:8517
2565 1440-1444 Gene denotes NEMO Gene:8517
2566 1472-1475 Gene denotes IFN Gene:3439
2567 1511-1514 Gene denotes IFN Gene:3439
2568 1616-1621 Gene denotes IFN-β Gene:3439
2569 1717-1725 Gene denotes helicase Gene:164045
2570 1958-1961 Gene denotes IFN Gene:3439
2571 2005-2010 Gene denotes EndoU Gene:8909
2572 2012-2015 Gene denotes IFN Gene:3439
2573 2167-2170 Gene denotes IFN Gene:3439
2574 832-836 Gene denotes nsp1 Gene:10045
2575 47-51 Species denotes PEDV Tax:28295
2576 806-810 Species denotes PEDV Tax:28295
2577 510-514 Species denotes PEDV Tax:28295
2578 1261-1264 Gene denotes IFN Gene:3439
2579 362-368 Disease denotes stress MESH:D000079225
2580 545-563 Disease denotes growth retardation MESH:D006130
2581 679-685 Disease denotes stress MESH:D000079225
2583 26-30 Species denotes PEDV Tax:28295