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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":299,"end":308},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"Table 1 The functions of PEDV viral proteins.\nPEDV Proteins The Biological Processes Involved References\nS (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]\nN viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]\nM virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]\nE virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]\nORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]\nnsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]\nnsp2 Unknown\nnsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]\nnsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]\nnsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]\nnsp12 encoding a RdRp; viral replication [134]\nnsp13 a NTPase/helicase that is essential for viral replication [111]\nnsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]\nnsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]\nnsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]"}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T120","span":{"begin":908,"end":911},"obj":"Disease"}],"attributes":[{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0010565"}],"text":"Table 1 The functions of PEDV viral proteins.\nPEDV Proteins The Biological Processes Involved References\nS (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]\nN viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]\nM virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]\nE virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]\nORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]\nnsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]\nnsp2 Unknown\nnsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]\nnsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]\nnsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]\nnsp12 encoding a RdRp; viral replication [134]\nnsp13 a NTPase/helicase that is essential for viral replication [111]\nnsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]\nnsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]\nnsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]"}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T30","span":{"begin":545,"end":563},"obj":"Phenotype"}],"attributes":[{"id":"A30","pred":"hp_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/HP_0001510"}],"text":"Table 1 The functions of PEDV viral proteins.\nPEDV Proteins The Biological Processes Involved References\nS (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]\nN viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]\nM virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]\nE virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]\nORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]\nnsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]\nnsp2 Unknown\nnsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]\nnsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]\nnsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]\nnsp12 encoding a RdRp; viral replication [134]\nnsp13 a NTPase/helicase that is essential for viral replication [111]\nnsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]\nnsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]\nnsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]"}

LitCovid-PD-GO-BP

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T419","span":{"begin":0,"end":46},"obj":"Sentence"},{"id":"T420","span":{"begin":47,"end":107},"obj":"Sentence"},{"id":"T421","span":{"begin":108,"end":247},"obj":"Sentence"},{"id":"T422","span":{"begin":248,"end":458},"obj":"Sentence"},{"id":"T423","span":{"begin":459,"end":628},"obj":"Sentence"},{"id":"T424","span":{"begin":629,"end":726},"obj":"Sentence"},{"id":"T425","span":{"begin":727,"end":831},"obj":"Sentence"},{"id":"T426","span":{"begin":832,"end":1058},"obj":"Sentence"},{"id":"T427","span":{"begin":1059,"end":1072},"obj":"Sentence"},{"id":"T428","span":{"begin":1073,"end":1286},"obj":"Sentence"},{"id":"T429","span":{"begin":1287,"end":1451},"obj":"Sentence"},{"id":"T430","span":{"begin":1452,"end":1651},"obj":"Sentence"},{"id":"T431","span":{"begin":1652,"end":1700},"obj":"Sentence"},{"id":"T432","span":{"begin":1701,"end":1772},"obj":"Sentence"},{"id":"T433","span":{"begin":1773,"end":1997},"obj":"Sentence"},{"id":"T434","span":{"begin":1998,"end":2106},"obj":"Sentence"},{"id":"T435","span":{"begin":2107,"end":2208},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 1 The functions of PEDV viral proteins.\nPEDV Proteins The Biological Processes Involved References\nS (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]\nN viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]\nM virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]\nE virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]\nORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]\nnsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]\nnsp2 Unknown\nnsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]\nnsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]\nnsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]\nnsp12 encoding a RdRp; viral replication [134]\nnsp13 a NTPase/helicase that is essential for viral replication [111]\nnsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]\nnsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]\nnsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]"}

LitCovid-PubTator

PMC:7281546 / 54901-57109 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7281546 / 54901-57109 JSON TXT