PMC:7281546 / 54068-54900 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7281546","sourcedb":"PMC","sourceid":"7281546","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7281546","text":"Figure 3 The action model of PEDV interferons (IFNs) antagonists. For type I IFN, PEDV PLP2 removes ubiquitinated conjugates from RIG-I; PEDV nsp5 induces cleavage of NEMO; PEDV N protein directly interacts with TBK1 to obstruct the association between TBK1 and IRF3; PEDV nsp1 causes degradation of CBP and IκBα, as well as inhibition of IκBα phosphorylation and p65 activation. PEDV nsp16 inhibits type I IFN production and nsp10 enhances the inhibitory effect of nsp16 on type I IFN production. For type III IFN, PEDV N protein blocks the nuclear translocation of NF-κB; PEDV nsp1 blocks the nuclear translocation of IRF1 and reduces the amounts of peroxisomes. PEDV nsp15 inhibits the type I IFN and type III IFN responses by unknown mechanisms. PEDV nsp7 interacts with STAT1 and STAT2 to block nuclear translocation of ISGF3.","divisions":[{"label":"label","span":{"begin":0,"end":8}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T329","span":{"begin":181,"end":188},"obj":"Body_part"},{"id":"T330","span":{"begin":524,"end":531},"obj":"Body_part"},{"id":"T331","span":{"begin":653,"end":664},"obj":"Body_part"}],"attributes":[{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma63845"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":301,"end":304},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0010565"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T506","span":{"begin":311,"end":312},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T507","span":{"begin":342,"end":343},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T508","span":{"begin":369,"end":379},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T509","span":{"begin":572,"end":573},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T510","span":{"begin":697,"end":713},"obj":"http://purl.obolibrary.org/obo/PR_000024990"}],"attributes":[{"subj":"T506","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T507","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T508","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T510","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T92358","span":{"begin":54,"end":65},"obj":"Chemical"},{"id":"T77304","span":{"begin":181,"end":188},"obj":"Chemical"},{"id":"T51413","span":{"begin":524,"end":531},"obj":"Chemical"},{"id":"T11713","span":{"begin":568,"end":570},"obj":"Chemical"}],"attributes":[{"id":"A92618","pred":"chebi_id","subj":"T92358","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A85411","pred":"chebi_id","subj":"T77304","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A71584","pred":"chebi_id","subj":"T51413","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A75887","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A50412","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A43437","pred":"chebi_id","subj":"T11713","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"subj":"T92358","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77304","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51413","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11713","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T418","span":{"begin":213,"end":217},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T419","span":{"begin":254,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T420","span":{"begin":286,"end":297},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T421","span":{"begin":345,"end":360},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T422","span":{"begin":401,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T423","span":{"begin":476,"end":497},"obj":"http://purl.obolibrary.org/obo/GO_0032606"}],"attributes":[{"subj":"T418","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T420","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T421","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T422","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T413","span":{"begin":0,"end":66},"obj":"Sentence"},{"id":"T414","span":{"begin":67,"end":380},"obj":"Sentence"},{"id":"T415","span":{"begin":381,"end":498},"obj":"Sentence"},{"id":"T416","span":{"begin":499,"end":665},"obj":"Sentence"},{"id":"T417","span":{"begin":666,"end":750},"obj":"Sentence"},{"id":"T418","span":{"begin":751,"end":832},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T413","pred":"source","obj":"LitCovid-sentences"},{"subj":"T414","pred":"source","obj":"LitCovid-sentences"},{"subj":"T415","pred":"source","obj":"LitCovid-sentences"},{"subj":"T416","pred":"source","obj":"LitCovid-sentences"},{"subj":"T417","pred":"source","obj":"LitCovid-sentences"},{"subj":"T418","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2494","span":{"begin":88,"end":92},"obj":"Gene"},{"id":"2495","span":{"begin":131,"end":136},"obj":"Gene"},{"id":"2496","span":{"begin":143,"end":147},"obj":"Gene"},{"id":"2497","span":{"begin":168,"end":172},"obj":"Gene"},{"id":"2498","span":{"begin":213,"end":217},"obj":"Gene"},{"id":"2499","span":{"begin":254,"end":258},"obj":"Gene"},{"id":"2500","span":{"begin":263,"end":267},"obj":"Gene"},{"id":"2501","span":{"begin":274,"end":278},"obj":"Gene"},{"id":"2502","span":{"begin":301,"end":304},"obj":"Gene"},{"id":"2503","span":{"begin":309,"end":313},"obj":"Gene"},{"id":"2504","span":{"begin":340,"end":344},"obj":"Gene"},{"id":"2505","span":{"begin":365,"end":368},"obj":"Gene"},{"id":"2506","span":{"begin":568,"end":573},"obj":"Gene"},{"id":"2507","span":{"begin":580,"end":584},"obj":"Gene"},{"id":"2508","span":{"begin":621,"end":625},"obj":"Gene"},{"id":"2509","span":{"begin":776,"end":781},"obj":"Gene"},{"id":"2510","span":{"begin":786,"end":791},"obj":"Gene"},{"id":"2511","span":{"begin":826,"end":831},"obj":"Gene"},{"id":"2512","span":{"begin":30,"end":34},"obj":"Species"},{"id":"2513","span":{"begin":83,"end":87},"obj":"Species"},{"id":"2514","span":{"begin":138,"end":142},"obj":"Species"},{"id":"2515","span":{"begin":174,"end":178},"obj":"Species"},{"id":"2516","span":{"begin":269,"end":273},"obj":"Species"},{"id":"2517","span":{"begin":381,"end":385},"obj":"Species"},{"id":"2518","span":{"begin":575,"end":579},"obj":"Species"},{"id":"2519","span":{"begin":666,"end":670},"obj":"Species"},{"id":"2520","span":{"begin":751,"end":755},"obj":"Species"},{"id":"2521","span":{"begin":512,"end":515},"obj":"Gene"}],"attributes":[{"id":"A2494","pred":"tao:has_database_id","subj":"2494","obj":"Gene:5355"},{"id":"A2495","pred":"tao:has_database_id","subj":"2495","obj":"Gene:23586"},{"id":"A2496","pred":"tao:has_database_id","subj":"2496","obj":"Gene:92521"},{"id":"A2497","pred":"tao:has_database_id","subj":"2497","obj":"Gene:8517"},{"id":"A2498","pred":"tao:has_database_id","subj":"2498","obj":"Gene:29110"},{"id":"A2499","pred":"tao:has_database_id","subj":"2499","obj":"Gene:29110"},{"id":"A2500","pred":"tao:has_database_id","subj":"2500","obj":"Gene:3661"},{"id":"A2501","pred":"tao:has_database_id","subj":"2501","obj":"Gene:10045"},{"id":"A2502","pred":"tao:has_database_id","subj":"2502","obj":"Gene:1387"},{"id":"A2503","pred":"tao:has_database_id","subj":"2503","obj":"Gene:4792"},{"id":"A2504","pred":"tao:has_database_id","subj":"2504","obj":"Gene:4792"},{"id":"A2505","pred":"tao:has_database_id","subj":"2505","obj":"Gene:5970"},{"id":"A2506","pred":"tao:has_database_id","subj":"2506","obj":"Gene:4790"},{"id":"A2507","pred":"tao:has_database_id","subj":"2507","obj":"Gene:10045"},{"id":"A2508","pred":"tao:has_database_id","subj":"2508","obj":"Gene:3659"},{"id":"A2509","pred":"tao:has_database_id","subj":"2509","obj":"Gene:6772"},{"id":"A2510","pred":"tao:has_database_id","subj":"2510","obj":"Gene:6773"},{"id":"A2511","pred":"tao:has_database_id","subj":"2511","obj":"Gene:10379"},{"id":"A2512","pred":"tao:has_database_id","subj":"2512","obj":"Tax:28295"},{"id":"A2513","pred":"tao:has_database_id","subj":"2513","obj":"Tax:28295"},{"id":"A2514","pred":"tao:has_database_id","subj":"2514","obj":"Tax:28295"},{"id":"A2515","pred":"tao:has_database_id","subj":"2515","obj":"Tax:28295"},{"id":"A2516","pred":"tao:has_database_id","subj":"2516","obj":"Tax:28295"},{"id":"A2517","pred":"tao:has_database_id","subj":"2517","obj":"Tax:28295"},{"id":"A2518","pred":"tao:has_database_id","subj":"2518","obj":"Tax:28295"},{"id":"A2519","pred":"tao:has_database_id","subj":"2519","obj":"Tax:28295"},{"id":"A2520","pred":"tao:has_database_id","subj":"2520","obj":"Tax:28295"},{"id":"A2521","pred":"tao:has_database_id","subj":"2521","obj":"Gene:3439"},{"subj":"2494","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2495","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2496","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2502","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2503","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2504","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2505","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2506","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2507","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2508","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2516","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2517","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2519","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2520","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2521","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecc093","default":true},{"id":"LitCovid-PD-MONDO","color":"#a693ec"},{"id":"LitCovid-PD-CLO","color":"#9aec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b4"},{"id":"LitCovid-PD-GO-BP","color":"#93ceec"},{"id":"LitCovid-sentences","color":"#e8ec93"},{"id":"LitCovid-PubTator","color":"#d693ec"}]}]}}