PMC:7281546 / 48812-49827
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7281546","sourcedb":"PMC","sourceid":"7281546","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7281546","text":"The multiple stages of CoV replication cycle are closely associated with cellular membrane compartments, especially the endoplasmic reticulum (ER). The shape and functions of ER can be influenced by different physiological states and environmental conditions. When protein synthesis amounts surpass the folding capacity, the accumulation of a large amount of unfolded proteins in the ER leads to ER stress. Consequently, cells manifest a corresponding biological reaction that is widely known as the unfolded protein response (UPR) [233]. Once the UPR is induced, it alleviates the problems by host protein translation inhibition (by the transducer PKR-like ER protein kinase (PERK)-induced phosphorylation of eIF2a), stimulating protein folding. If homeostasis cannot be re-established, apoptosis eventually is triggered. Indeed, the activation of UPR regulates a wide variety of signaling pathways, such as apoptosis, autophagy, mitogen-activated protein (MAP) kinase activation, and innate immune response [234].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T280","span":{"begin":73,"end":90},"obj":"Body_part"},{"id":"T281","span":{"begin":91,"end":103},"obj":"Body_part"},{"id":"T282","span":{"begin":120,"end":141},"obj":"Body_part"},{"id":"T283","span":{"begin":143,"end":145},"obj":"Body_part"},{"id":"T284","span":{"begin":175,"end":177},"obj":"Body_part"},{"id":"T285","span":{"begin":265,"end":272},"obj":"Body_part"},{"id":"T286","span":{"begin":368,"end":376},"obj":"Body_part"},{"id":"T287","span":{"begin":384,"end":386},"obj":"Body_part"},{"id":"T288","span":{"begin":396,"end":398},"obj":"Body_part"},{"id":"T289","span":{"begin":421,"end":426},"obj":"Body_part"},{"id":"T290","span":{"begin":509,"end":516},"obj":"Body_part"},{"id":"T291","span":{"begin":599,"end":606},"obj":"Body_part"},{"id":"T292","span":{"begin":658,"end":660},"obj":"Body_part"},{"id":"T293","span":{"begin":661,"end":668},"obj":"Body_part"},{"id":"T294","span":{"begin":730,"end":737},"obj":"Body_part"},{"id":"T295","span":{"begin":949,"end":956},"obj":"Body_part"},{"id":"T296","span":{"begin":958,"end":961},"obj":"Body_part"}],"attributes":[{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A281","pred":"fma_id","subj":"T281","obj":"http://purl.org/sig/ont/fma/fma76577"},{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A292","pred":"fma_id","subj":"T292","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma67847"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T292","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T470","span":{"begin":82,"end":90},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T471","span":{"begin":341,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T472","span":{"begin":421,"end":426},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T473","span":{"begin":436,"end":437},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T474","span":{"begin":835,"end":845},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T475","span":{"begin":863,"end":864},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T476","span":{"begin":881,"end":890},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T477","span":{"begin":939,"end":948},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T478","span":{"begin":970,"end":980},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T470","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T471","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T472","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T473","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T474","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T475","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T476","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T477","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T478","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T391","span":{"begin":265,"end":272},"obj":"Chemical"},{"id":"T392","span":{"begin":368,"end":376},"obj":"Chemical"},{"id":"T393","span":{"begin":509,"end":516},"obj":"Chemical"},{"id":"T394","span":{"begin":599,"end":606},"obj":"Chemical"},{"id":"T395","span":{"begin":661,"end":668},"obj":"Chemical"},{"id":"T396","span":{"begin":677,"end":681},"obj":"Chemical"},{"id":"T397","span":{"begin":730,"end":737},"obj":"Chemical"},{"id":"T398","span":{"begin":931,"end":938},"obj":"Chemical"},{"id":"T399","span":{"begin":949,"end":956},"obj":"Chemical"},{"id":"T400","span":{"begin":958,"end":961},"obj":"Chemical"}],"attributes":[{"id":"A391","pred":"chebi_id","subj":"T391","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A392","pred":"chebi_id","subj":"T392","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A393","pred":"chebi_id","subj":"T393","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A394","pred":"chebi_id","subj":"T394","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A395","pred":"chebi_id","subj":"T395","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A396","pred":"chebi_id","subj":"T396","obj":"http://purl.obolibrary.org/obo/CHEBI_17300"},{"id":"A397","pred":"chebi_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A398","pred":"chebi_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/CHEBI_52290"},{"id":"A399","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A400","pred":"chebi_id","subj":"T400","obj":"http://purl.obolibrary.org/obo/CHEBI_6716"},{"subj":"T391","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T392","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T393","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T394","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T395","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T396","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T397","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T398","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T399","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T400","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T366","span":{"begin":265,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T367","span":{"begin":273,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T368","span":{"begin":599,"end":618},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T369","span":{"begin":691,"end":706},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T370","span":{"begin":730,"end":745},"obj":"http://purl.obolibrary.org/obo/GO_0006457"},{"id":"T371","span":{"begin":750,"end":761},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T372","span":{"begin":788,"end":797},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T373","span":{"begin":788,"end":797},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T374","span":{"begin":881,"end":899},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T375","span":{"begin":881,"end":890},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T376","span":{"begin":909,"end":918},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T377","span":{"begin":909,"end":918},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T378","span":{"begin":920,"end":929},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T379","span":{"begin":920,"end":929},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T380","span":{"begin":970,"end":1008},"obj":"http://purl.obolibrary.org/obo/GO_0002218"},{"id":"T381","span":{"begin":986,"end":1008},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T382","span":{"begin":993,"end":1008},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T366","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T382","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T366","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T367","span":{"begin":148,"end":259},"obj":"Sentence"},{"id":"T368","span":{"begin":260,"end":406},"obj":"Sentence"},{"id":"T369","span":{"begin":407,"end":538},"obj":"Sentence"},{"id":"T370","span":{"begin":539,"end":746},"obj":"Sentence"},{"id":"T371","span":{"begin":747,"end":822},"obj":"Sentence"},{"id":"T372","span":{"begin":823,"end":1015},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T366","pred":"source","obj":"LitCovid-sentences"},{"subj":"T367","pred":"source","obj":"LitCovid-sentences"},{"subj":"T368","pred":"source","obj":"LitCovid-sentences"},{"subj":"T369","pred":"source","obj":"LitCovid-sentences"},{"subj":"T370","pred":"source","obj":"LitCovid-sentences"},{"subj":"T371","pred":"source","obj":"LitCovid-sentences"},{"subj":"T372","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32403318-17565364-82827501","span":{"begin":533,"end":536},"obj":"17565364"},{"id":"32403318-24987391-82827502","span":{"begin":1010,"end":1013},"obj":"24987391"}],"attributes":[{"subj":"32403318-17565364-82827501","pred":"source","obj":"2_test"},{"subj":"32403318-24987391-82827502","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1632","span":{"begin":677,"end":681},"obj":"Gene"},{"id":"1633","span":{"begin":710,"end":715},"obj":"Gene"},{"id":"1634","span":{"begin":23,"end":26},"obj":"Species"},{"id":"1635","span":{"begin":399,"end":405},"obj":"Disease"}],"attributes":[{"id":"A1632","pred":"tao:has_database_id","subj":"1632","obj":"Gene:9451"},{"id":"A1633","pred":"tao:has_database_id","subj":"1633","obj":"Gene:1965"},{"id":"A1634","pred":"tao:has_database_id","subj":"1634","obj":"Tax:11118"},{"id":"A1635","pred":"tao:has_database_id","subj":"1635","obj":"MESH:D000079225"},{"subj":"1632","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1633","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1634","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1635","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecba","default":true},{"id":"LitCovid-PD-CLO","color":"#eca093"},{"id":"LitCovid-PD-CHEBI","color":"#93a0ec"},{"id":"LitCovid-PD-GO-BP","color":"#baec93"},{"id":"LitCovid-sentences","color":"#ec93d4"},{"id":"2_test","color":"#93ecea"},{"id":"LitCovid-PubTator","color":"#ecd093"}]}]}}