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LitCovid-PD-FMA-UBERON

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T64","span":{"begin":1105,"end":1113},"obj":"Disease"},{"id":"T65","span":{"begin":1329,"end":1337},"obj":"Disease"},{"id":"T66","span":{"begin":1911,"end":1926},"obj":"Disease"},{"id":"T67","span":{"begin":1917,"end":1926},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"4.2.1. PEDV N Protein\nN protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134]. PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58]. PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3. Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58]. Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168]. N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].\nRecent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171]. The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171]. In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61]. These results indicate the important function of the CoVs N protein in modulating host innate immune response. Whether PEDV N protein targets TRIM25 or PACT should be investigated.\nAlthough several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection. CoV N protein is a vital viral protein involved in virus replication. Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176]. In the host cells, a large number of host proteins reveal various functions. However, for the virus, the genome only encodes several limited viral proteins. Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence."}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T171","span":{"begin":158,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T172","span":{"begin":423,"end":427},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T173","span":{"begin":608,"end":612},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T174","span":{"begin":649,"end":653},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T175","span":{"begin":679,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T176","span":{"begin":697,"end":712},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T177","span":{"begin":782,"end":805},"obj":"http://purl.obolibrary.org/obo/GO_0034343"},{"id":"T178","span":{"begin":1133,"end":1154},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T179","span":{"begin":1254,"end":1268},"obj":"http://purl.obolibrary.org/obo/GO_0072647"},{"id":"T180","span":{"begin":1473,"end":1487},"obj":"http://purl.obolibrary.org/obo/GO_0072647"},{"id":"T181","span":{"begin":1520,"end":1529},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T182","span":{"begin":1607,"end":1645},"obj":"http://purl.obolibrary.org/obo/GO_0052167"},{"id":"T183","span":{"begin":1623,"end":1645},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T184","span":{"begin":1630,"end":1645},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T185","span":{"begin":1662,"end":1677},"obj":"http://purl.obolibrary.org/obo/GO_0006605"},{"id":"T186","span":{"begin":1911,"end":1926},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"4.2.1. PEDV N Protein\nN protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134]. PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58]. PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3. Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58]. Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168]. N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].\nRecent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171]. The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171]. In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61]. These results indicate the important function of the CoVs N protein in modulating host innate immune response. Whether PEDV N protein targets TRIM25 or PACT should be investigated.\nAlthough several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection. CoV N protein is a vital viral protein involved in virus replication. Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176]. In the host cells, a large number of host proteins reveal various functions. However, for the virus, the genome only encodes several limited viral proteins. Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T201","span":{"begin":0,"end":6},"obj":"Sentence"},{"id":"T202","span":{"begin":7,"end":21},"obj":"Sentence"},{"id":"T203","span":{"begin":22,"end":195},"obj":"Sentence"},{"id":"T204","span":{"begin":196,"end":350},"obj":"Sentence"},{"id":"T205","span":{"begin":351,"end":548},"obj":"Sentence"},{"id":"T206","span":{"begin":549,"end":739},"obj":"Sentence"},{"id":"T207","span":{"begin":740,"end":836},"obj":"Sentence"},{"id":"T208","span":{"begin":837,"end":1079},"obj":"Sentence"},{"id":"T209","span":{"begin":1080,"end":1218},"obj":"Sentence"},{"id":"T210","span":{"begin":1219,"end":1302},"obj":"Sentence"},{"id":"T211","span":{"begin":1303,"end":1535},"obj":"Sentence"},{"id":"T212","span":{"begin":1536,"end":1646},"obj":"Sentence"},{"id":"T213","span":{"begin":1647,"end":1716},"obj":"Sentence"},{"id":"T214","span":{"begin":1717,"end":1927},"obj":"Sentence"},{"id":"T215","span":{"begin":1928,"end":1997},"obj":"Sentence"},{"id":"T216","span":{"begin":1998,"end":2193},"obj":"Sentence"},{"id":"T217","span":{"begin":2194,"end":2270},"obj":"Sentence"},{"id":"T218","span":{"begin":2271,"end":2350},"obj":"Sentence"},{"id":"T219","span":{"begin":2351,"end":2463},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.2.1. PEDV N Protein\nN protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134]. PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58]. PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3. Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58]. Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168]. N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].\nRecent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171]. The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171]. In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61]. These results indicate the important function of the CoVs N protein in modulating host innate immune response. Whether PEDV N protein targets TRIM25 or PACT should be investigated.\nAlthough several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection. CoV N protein is a vital viral protein involved in virus replication. Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176]. In the host cells, a large number of host proteins reveal various functions. However, for the virus, the genome only encodes several limited viral proteins. Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence."}

2_test

{"project":"2_test","denotations":[{"id":"32403318-16971454-82827402","span":{"begin":187,"end":189},"obj":"16971454"},{"id":"32403318-28643204-82827403","span":{"begin":190,"end":193},"obj":"28643204"},{"id":"32403318-24872591-82827404","span":{"begin":346,"end":348},"obj":"24872591"},{"id":"32403318-24872591-82827405","span":{"begin":735,"end":737},"obj":"24872591"},{"id":"32403318-28591694-82827406","span":{"begin":1531,"end":1533},"obj":"28591694"},{"id":"32403318-15358143-82827407","span":{"begin":2097,"end":2100},"obj":"15358143"},{"id":"32403318-20478047-82827408","span":{"begin":2127,"end":2130},"obj":"20478047"},{"id":"32403318-18055455-82827409","span":{"begin":2140,"end":2143},"obj":"18055455"},{"id":"32403318-10603321-82827410","span":{"begin":2156,"end":2159},"obj":"10603321"},{"id":"32403318-20960183-82827411","span":{"begin":2188,"end":2191},"obj":"20960183"}],"text":"4.2.1. PEDV N Protein\nN protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134]. PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58]. PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3. Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58]. Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168]. N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].\nRecent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171]. The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171]. In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61]. These results indicate the important function of the CoVs N protein in modulating host innate immune response. Whether PEDV N protein targets TRIM25 or PACT should be investigated.\nAlthough several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection. CoV N protein is a vital viral protein involved in virus replication. Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176]. In the host cells, a large number of host proteins reveal various functions. However, for the virus, the genome only encodes several limited viral proteins. Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence."}

LitCovid-PubTator

PMC:7281546 / 28646-31109 JSONTXT

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PMC:7281546 / 28646-31109 JSON TXT