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PMC:7281546 / 28646-31109 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T167 14-21 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T168 24-31 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 70-77 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 98-103 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T171 203-210 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 358-365 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T173 771-778 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 839-846 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T175 1067-1072 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T176 1116-1123 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 1234-1241 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T178 1340-1348 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T179 1382-1389 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T180 1403-1410 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T181 1596-1603 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T182 1662-1669 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 1873-1881 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T184 1891-1895 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T185 1934-1941 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 1959-1966 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T187 2039-2046 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 2072-2080 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T189 2152-2154 Body_part denotes A1 http://purl.org/sig/ont/fma/fma66592
T190 2170-2179 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T191 2206-2211 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 2236-2244 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T193 2299-2305 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T194 2341-2349 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T195 2374-2382 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T64 1105-1113 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 1329-1337 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 1911-1926 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T67 1917-1926 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T252 98-103 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T253 105-108 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T254 139-144 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T255 211-214 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 332-333 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T257 334-344 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T258 379-389 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T259 500-510 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T260 806-809 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T261 971-972 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T262 1067-1072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T263 1390-1399 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T264 1464-1472 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T265 1520-1529 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T266 1891-1895 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T267 1945-1946 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 1979-1984 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T269 2206-2211 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T270 2213-2214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 2288-2293 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T272 2431-2436 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T224 14-21 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T225 24-31 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T226 70-77 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T227 203-210 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T228 237-240 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T229 241-251 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T230 282-285 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T231 328-330 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T234 358-365 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T235 397-400 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T236 452-455 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T237 518-521 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T238 717-720 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T239 771-778 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T240 791-794 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T241 839-846 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T242 856-887 Chemical denotes polyinosinic-polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84491
T243 869-887 Chemical denotes polycytidylic acid http://purl.obolibrary.org/obo/CHEBI_84498
T244 883-887 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T245 889-898 Chemical denotes poly(I:C) http://purl.obolibrary.org/obo/CHEBI_84491
T246 908-911 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T247 967-969 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T250 1017-1019 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T251 1020-1023 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T252 1046-1055 Chemical denotes poly(I:C) http://purl.obolibrary.org/obo/CHEBI_84491
T253 1116-1123 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T254 1140-1143 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T255 1234-1241 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 1254-1257 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T257 1340-1348 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T258 1382-1389 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 1403-1410 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T260 1473-1476 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T261 1516-1519 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T262 1596-1603 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T263 1662-1669 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T264 1873-1881 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T265 1934-1941 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T266 1959-1966 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T267 2039-2046 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T268 2072-2080 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T269 2236-2244 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T270 2341-2349 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T271 2374-2382 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T171 158-171 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T172 423-427 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T173 608-612 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T174 649-653 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T175 679-683 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T176 697-712 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T177 782-805 http://purl.obolibrary.org/obo/GO_0034343 denotes type III IFN production
T178 1133-1154 http://purl.obolibrary.org/obo/GO_0032606 denotes type I IFN production
T179 1254-1268 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T180 1473-1487 http://purl.obolibrary.org/obo/GO_0072647 denotes IFN production
T181 1520-1529 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T182 1607-1645 http://purl.obolibrary.org/obo/GO_0052167 denotes modulating host innate immune response
T183 1623-1645 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T184 1630-1645 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T185 1662-1677 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets
T186 1911-1926 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T201 0-6 Sentence denotes 4.2.1.
T202 7-21 Sentence denotes PEDV N Protein
T203 22-195 Sentence denotes N protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134].
T204 196-350 Sentence denotes PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58].
T205 351-548 Sentence denotes PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3.
T206 549-739 Sentence denotes Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58].
T207 740-836 Sentence denotes Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168].
T208 837-1079 Sentence denotes N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168].
T209 1080-1218 Sentence denotes Recent studies show that SARS-CoV N protein inhibits type I IFN production through suppressing TRIM25-mediated RIG-I ubiquitination [171].
T210 1219-1302 Sentence denotes The MERS-CoV N protein also blocks IFN production by interacting with TRIM25 [171].
T211 1303-1535 Sentence denotes In addition, both MHV and SARS-CoV N proteins perturb the function of cellular protein activator of protein kinase R (PACT), which can bind to RIG-I and MDA5 to activate IFN production, and thus antagonize type-I IFN signaling [61].
T212 1536-1646 Sentence denotes These results indicate the important function of the CoVs N protein in modulating host innate immune response.
T213 1647-1716 Sentence denotes Whether PEDV N protein targets TRIM25 or PACT should be investigated.
T214 1717-1927 Sentence denotes Although several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection.
T215 1928-1997 Sentence denotes CoV N protein is a vital viral protein involved in virus replication.
T216 1998-2193 Sentence denotes Current researches have indicated that N protein interacts with many host proteins, such as hCypA [172], proteasome subunit p42 [173], Smad3 [174], hnRNP-A1 [175], and the chemokine CXCL16 [176].
T217 2194-2270 Sentence denotes In the host cells, a large number of host proteins reveal various functions.
T218 2271-2350 Sentence denotes However, for the virus, the genome only encodes several limited viral proteins.
T219 2351-2463 Sentence denotes Therefore, these viral proteins have to be multifunctional, which is pivotal to virus replication and existence.

2_test

Id Subject Object Predicate Lexical cue
32403318-16971454-82827402 187-189 16971454 denotes 56
32403318-28643204-82827403 190-193 28643204 denotes 134
32403318-24872591-82827404 346-348 24872591 denotes 58
32403318-24872591-82827405 735-737 24872591 denotes 58
32403318-28591694-82827406 1531-1533 28591694 denotes 61
32403318-15358143-82827407 2097-2100 15358143 denotes 172
32403318-20478047-82827408 2127-2130 20478047 denotes 173
32403318-18055455-82827409 2140-2143 18055455 denotes 174
32403318-10603321-82827410 2156-2159 10603321 denotes 175
32403318-20960183-82827411 2188-2191 20960183 denotes 176

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
845 2-5 Gene denotes 2.1 Gene:6700
875 237-240 Gene denotes IFN Gene:3439
876 282-287 Gene denotes IFN-β Gene:3439
877 319-323 Gene denotes IRF3 Gene:3661
878 328-333 Gene denotes NF-κB Gene:4790
879 397-402 Gene denotes IFN-β Gene:3439
880 423-427 Gene denotes TBK1 Gene:29110
881 445-450 Gene denotes RIG-I Gene:23586
882 452-457 Gene denotes MDA-5 Gene:64135
883 459-463 Gene denotes VISA Gene:57506
884 469-474 Gene denotes TRAF3 Gene:7187
885 518-523 Gene denotes IFN-β Gene:3439
886 543-547 Gene denotes IRF3 Gene:3661
887 608-612 Gene denotes TBK1 Gene:29110
888 649-653 Gene denotes TBK1 Gene:29110
889 658-662 Gene denotes IRF3 Gene:3661
890 679-683 Gene denotes TBK1 Gene:29110
891 692-696 Gene denotes IRF3 Gene:3661
892 717-722 Gene denotes IFN-β Gene:3439
893 908-914 Gene denotes IFN-λ3 Gene:282617
894 967-972 Gene denotes NF-κB Gene:4790
895 196-200 Species denotes PEDV Tax:28295
896 351-355 Species denotes PEDV Tax:28295
897 764-768 Species denotes PEDV Tax:28295
898 1020-1023 Gene denotes IFN Gene:3439
899 856-887 Chemical denotes polyinosinic-polycytidylic acid MESH:D011070
900 889-898 Chemical denotes poly(I:C) MESH:D011070
901 1046-1055 Chemical denotes poly(I:C) MESH:D011070
902 85-97 Disease denotes CoV-infected MESH:D018352
903 1059-1066 CellLine denotes IPEC-J2 CVCL:2246
921 1175-1181 Gene denotes TRIM25 Gene:7706
922 1191-1196 Gene denotes RIG-I Gene:23586
923 1254-1257 Gene denotes IFN Gene:3439
924 1289-1295 Gene denotes TRIM25 Gene:7706
925 1403-1419 Gene denotes protein kinase R Gene:5610
926 1421-1425 Gene denotes PACT Gene:8575
927 1446-1451 Gene denotes RIG-I Gene:23586
928 1456-1460 Gene denotes MDA5 Gene:64135
929 1473-1476 Gene denotes IFN Gene:3439
930 1678-1684 Gene denotes TRIM25 Gene:7706
931 1688-1692 Gene denotes PACT Gene:8575
932 1516-1519 Gene denotes IFN Gene:3439
933 1105-1113 Species denotes SARS-CoV Tax:694009
934 1223-1231 Species denotes MERS-CoV Tax:1335626
935 1589-1593 Species denotes CoVs Tax:11118
936 1321-1324 Species denotes MHV Tax:11138
937 1329-1356 Disease denotes SARS-CoV N proteins perturb MESH:C000657245
946 2090-2095 Gene denotes hCypA Gene:5478
947 2103-2125 Gene denotes proteasome subunit p42 Gene:5706
948 2133-2138 Gene denotes Smad3 Gene:4088
949 2146-2154 Gene denotes hnRNP-A1 Gene:3178
950 2180-2186 Gene denotes CXCL16 Gene:58191
951 1797-1801 Species denotes PEDV Tax:28295
952 1928-1931 Species denotes CoV Tax:11118
953 1911-1926 Disease denotes viral infection MESH:D001102