PMC:7281546 / 1190-9214 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7281546","sourcedb":"PMC","sourceid":"7281546","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7281546","text":"1. Introduction\nPorcine epidemic diarrhea virus (PEDV) is the etiological agent of porcine epidemic diarrhea (PED) that causes an acute and highly contagious enteric disease of swine characterized by vomiting, diarrhea, dehydration, and anorexia in pigs of all ages, especially resulting in severe diarrhea and high mortality rate in piglets. In serious cases, outbreak of PED even leads to a mortality rate of 100% in pigs [1,2,3]. The causative agent of PED was first described in the 1970s in England [4]. In 1976, an unrecognized enteric disease was reported in several European countries [5]. The viral diarrhea was collectively designated “PED” in 1982 [6]. Endemic PED had been described in both developed and developing countries, but with a low impact on the swine industry until 2010. In 2010, outbreaks of PED caused by highly pathogenic variant PEDV strains occurred in China, and this was immediately reported in other Asian counties, causing up to 100% mortality in suckling piglets [1,7,8,9]. In April 2013, PEDV entered the United States (US) for the first time and the virulent strains spread rapidly across the US [10]. Apart from almost 100% mortality rate in suckling piglets, PEDV infection also damaged the growth performance of finishing pigs [11]. The highly pathogenic strains of PEDV spread worldwide, resulting in serious problems to the swine industry and substantial economic losses [7,10,12,13]. Vaccination used to be the main strategy to prevent and control the rate of PEDV infection [14], however, the current available PEDV vaccines cannot provide complete protection for the pigs affected by the highly pathogenic strains. The optimal vaccines should induce efficient maternal antibodies in sows that could be transmitted to the offspring and protect neonatal suckling piglets from PEDV. The vaccination method is critically associated with the antibodies’ induction by PEDV vaccines. Oral vaccination with attenuated PEDV seems to be more efficacious than injectable vaccine. Oral immunization of PEDV-seronegative pregnant sows with attenuated PEDV leads to lower mortality rate of piglets and higher amounts of IgA transferred from the sows to the offspring than that in the intramuscularly injected group. However, the duration of virus shedding after challenge was not reduced compared to the control group [15]. The immunization dose of the virus for sows and the challenge dose of the virus for piglets significantly affected the protection against virus challenge [16]. Moreover, epidemiological studies have demonstrated that the prevalent strains causing previous PED outbreaks in China in 2010 and the recent outbreaks in North America and Asia all belong to the genogroup II (GII) PEDV and the S gene of GIIb PEDV contains typical insertion and deletion mutations [2]. Therefore, new PEDV vaccines should be developed based on these variant strains. The biological characteristics, pathogenicity and immune protective effects of GIIb PEDV strains should be studied as soon as possible. An inactivated vaccine based on genotype IIb strain AJ1102 developed by Wuhan Keqian company was approved for clinical trial in 2014. In addition, the lactic acid bacteria (LAB) that have the ability to interact with the intestinal cells can be used as a potential vector for improving delivery of oral vaccines [17]. Developing the transgenic plants expressing antigenic proteins as edible vaccines to induce efficient mucosal immune responses might be a prominent strategy to prevent PEDV infection [18]. Choosing appropriate and effective adjuvants for PEDV vaccines to enhance adaptive immune response is also important. In addition, the construction of recombinant PEDV with deletion or mutation of the immune antagonistic regions or sites is a potential strategy to develop PEDV vaccines as well. The produced modified antigens will induce an increased and earlier immune response in pigs, compared with the antigens from wildtype viruses. Therefore, the modification of viral antigens, the optimization of immunization methods, screening effective adjuvants, and exploiting a new generation of vaccines are promising directions for the control of PED.PEDV is classified as a coronavirus (CoV), due to its similar electron microscopic appearance and polypeptide structure to other CoVs [19,20,21]. CoVs (subfamily Coronavirinae, family Coronaviridae, order Nidovirales) are a large family of viruses that have broad host ranges and have caused global public health issues [22]. The currently known CoVs are divided into four genera, which include Alphacoronavirus (α-CoV), Betacoronavirus (β-CoV), Gammacoronavirus (γ-CoV) and Deltacoronavirus (δ-CoV), according to the genome phylogeny and serotypes. CoVs give rise to a wide spectrum of diseases in humans and animals, but generally fall into two classes, with respiratory or enteric tropisms. Moreover, the β-CoV genus consists of a lot of important CoVs that result in serious respiratory illnesses in humans, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the latest 2019 novel coronavirus (SARS-CoV2). SARS-CoV resulted in an outbreak of severe respiratory disease through China in 2002–2003 [23,24]. MERS-CoV was first identified in Saudi Arabia in 2012 and is associated with severe pneumonia and acute respiratory distress syndrome (ARDS) that results in a high mortality (~35%) [25,26]. SARS-CoV2 was identified in Wuhan, China in December 2019, which leads to similar symptoms in humans as SARS-CoV, but it is more infectious to humans than SARS-CoV [27,28]. Furthermore, α-CoV genus includes porcine respiratory coronavirus (PRCV) and various enteric CoVs that lead to viral diarrhea in pigs, such as PEDV, transmissible gastroenteritis virus (TGEV), and HKU2-like porcine enteric alphacoronavirus (PEAV) [29,30]. PRCV infects the upper respiratory epithelial cells and alveolar macrophages, but the clinical manifestations caused by PRCV are not significant [31]. The swine enteric CoVs cause severe diarrhea, vomiting, and mortality in piglets, having contributed to enormous economic losses to the global swine industry [6].\nPEDV is the main causative pathogen of viral diarrhea in piglets. Over the years, significant work has been done to investigate PEDV pathogenesis and prevention. Aminopeptidase N protein (APN, also known as CD13) is identified as a functional receptor of PEDV and TGEV [32,33,34]. APN, a 150 KD type II transmembrane glycoprotein, is mainly expressed on the apical membrane of mature enterocytes [35]. APN binds to the 477-629 amino-acid region in the C-terminal region of PEDV spike 1 (S1) protein [34]. Apart from APN, PEDV is able to bind to sialic acids [36]. It remains unknown whether PEDV uses sugar coreceptors during viral infection [34,36]. PEDV infects multiple cell lines from different species including bat and primate (human and non-human) in vitro. The ability of PEDV to infect the cells of different species indicates that the virus utilizes the evolutionarily conserved cell components as receptors, thereby enhancing the potential for cross-species and potentially, zoonotic transmission [37,38]. The highly pathogenic variant strains of PEDV were identified in 2010 and caused a high morbidity of up to 100% in piglets, and since then, these strains become dominant, leading to most of the acute outbreaks of PED worldwide [1,7,8]. The high virulence of these strains is critically associated with the immune evasion mechanisms employed by the virus. PEDV has evolved different strategies to delicately manipulate and damage the host innate immune system for their multiplication. Clarification of these mechanisms is critical for understanding the host range, tropisms, pathogenesis, and for developing effective vaccines and antiviral drugs to curb the spread of PEDV in pigs. In this review, we provide an overview of different mechanisms used by PEDV to evade host innate immune responses.","divisions":[{"label":"title","span":{"begin":0,"end":15}},{"label":"p","span":{"begin":16,"end":6209}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T4","span":{"begin":2150,"end":2153},"obj":"Body_part"},{"id":"T5","span":{"begin":2744,"end":2748},"obj":"Body_part"},{"id":"T6","span":{"begin":3255,"end":3265},"obj":"Body_part"},{"id":"T7","span":{"begin":3266,"end":3271},"obj":"Body_part"},{"id":"T8","span":{"begin":3406,"end":3414},"obj":"Body_part"},{"id":"T9","span":{"begin":4710,"end":4716},"obj":"Body_part"},{"id":"T10","span":{"begin":5931,"end":5947},"obj":"Body_part"},{"id":"T11","span":{"begin":5942,"end":5947},"obj":"Body_part"},{"id":"T12","span":{"begin":5952,"end":5972},"obj":"Body_part"},{"id":"T13","span":{"begin":6389,"end":6396},"obj":"Body_part"},{"id":"T14","span":{"begin":6527,"end":6539},"obj":"Body_part"},{"id":"T15","span":{"begin":6594,"end":6605},"obj":"Body_part"},{"id":"T16","span":{"begin":6637,"end":6647},"obj":"Body_part"},{"id":"T17","span":{"begin":6701,"end":6708},"obj":"Body_part"},{"id":"T18","span":{"begin":6811,"end":6816},"obj":"Body_part"},{"id":"T19","span":{"begin":6883,"end":6887},"obj":"Body_part"},{"id":"T20","span":{"begin":7009,"end":7014},"obj":"Body_part"},{"id":"T21","span":{"begin":7099,"end":7114},"obj":"Body_part"},{"id":"T22","span":{"begin":7099,"end":7103},"obj":"Body_part"},{"id":"T23","span":{"begin":7672,"end":7685},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma62874"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma83023"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma86454"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma9825"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":7672,"end":7685},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":33,"end":41},"obj":"Disease"},{"id":"T8","span":{"begin":100,"end":108},"obj":"Disease"},{"id":"T9","span":{"begin":166,"end":182},"obj":"Disease"},{"id":"T10","span":{"begin":210,"end":218},"obj":"Disease"},{"id":"T11","span":{"begin":298,"end":306},"obj":"Disease"},{"id":"T12","span":{"begin":608,"end":616},"obj":"Disease"},{"id":"T13","span":{"begin":1202,"end":1211},"obj":"Disease"},{"id":"T14","span":{"begin":1507,"end":1516},"obj":"Disease"},{"id":"T15","span":{"begin":3525,"end":3534},"obj":"Disease"},{"id":"T16","span":{"begin":5012,"end":5045},"obj":"Disease"},{"id":"T17","span":{"begin":5059,"end":5067},"obj":"Disease"},{"id":"T18","span":{"begin":5166,"end":5170},"obj":"Disease"},{"id":"T19","span":{"begin":5178,"end":5186},"obj":"Disease"},{"id":"T20","span":{"begin":5221,"end":5240},"obj":"Disease"},{"id":"T21","span":{"begin":5361,"end":5370},"obj":"Disease"},{"id":"T22","span":{"begin":5375,"end":5410},"obj":"Disease"},{"id":"T23","span":{"begin":5381,"end":5410},"obj":"Disease"},{"id":"T24","span":{"begin":5412,"end":5416},"obj":"Disease"},{"id":"T25","span":{"begin":5467,"end":5471},"obj":"Disease"},{"id":"T26","span":{"begin":5571,"end":5579},"obj":"Disease"},{"id":"T27","span":{"begin":5596,"end":5606},"obj":"Disease"},{"id":"T28","span":{"begin":5622,"end":5630},"obj":"Disease"},{"id":"T29","span":{"begin":5757,"end":5765},"obj":"Disease"},{"id":"T30","span":{"begin":5803,"end":5818},"obj":"Disease"},{"id":"T31","span":{"begin":5901,"end":5930},"obj":"Disease"},{"id":"T32","span":{"begin":6083,"end":6091},"obj":"Disease"},{"id":"T33","span":{"begin":6255,"end":6263},"obj":"Disease"},{"id":"T34","span":{"begin":6836,"end":6851},"obj":"Disease"},{"id":"T35","span":{"begin":6842,"end":6851},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0024990"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T9","span":{"begin":42,"end":47},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T10","span":{"begin":391,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":748,"end":749},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":1267,"end":1269},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T13","span":{"begin":2271,"end":2276},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T14","span":{"begin":2383,"end":2388},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T15","span":{"begin":2428,"end":2433},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T16","span":{"begin":2492,"end":2497},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T17","span":{"begin":2744,"end":2748},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T18","span":{"begin":3197,"end":3205},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T19","span":{"begin":3255,"end":3265},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T20","span":{"begin":3255,"end":3265},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T21","span":{"begin":3266,"end":3271},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T22","span":{"begin":3287,"end":3288},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T23","span":{"begin":3488,"end":3489},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24","span":{"begin":3536,"end":3538},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T25","span":{"begin":3782,"end":3783},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":3971,"end":3978},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T27","span":{"begin":4115,"end":4116},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":4214,"end":4215},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":4414,"end":4415},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T30","span":{"begin":4432,"end":4439},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T31","span":{"begin":4513,"end":4515},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T32","span":{"begin":4760,"end":4761},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T33","span":{"begin":4791,"end":4797},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T34","span":{"begin":4802,"end":4809},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T35","span":{"begin":4924,"end":4925},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T36","span":{"begin":4996,"end":5002},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T37","span":{"begin":5434,"end":5435},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T38","span":{"begin":5453,"end":5455},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T39","span":{"begin":5561,"end":5567},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T40","span":{"begin":5610,"end":5616},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T41","span":{"begin":5819,"end":5824},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T42","span":{"begin":5931,"end":5941},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T43","span":{"begin":5942,"end":5947},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T44","span":{"begin":6309,"end":6312},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T45","span":{"begin":6440,"end":6441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T46","span":{"begin":6496,"end":6497},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T47","span":{"begin":6575,"end":6583},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T48","span":{"begin":6607,"end":6609},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T49","span":{"begin":6697,"end":6699},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T50","span":{"begin":6710,"end":6712},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T51","span":{"begin":6769,"end":6771},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T52","span":{"begin":6883,"end":6893},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T53","span":{"begin":6927,"end":6930},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T54","span":{"begin":6935,"end":6942},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9443"},{"id":"T55","span":{"begin":6944,"end":6949},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T56","span":{"begin":6958,"end":6963},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T57","span":{"begin":7009,"end":7014},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T58","span":{"begin":7055,"end":7060},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T59","span":{"begin":7099,"end":7103},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T60","span":{"begin":7308,"end":7309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T61","span":{"begin":7575,"end":7580},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T62","span":{"begin":7587,"end":7590},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T63","span":{"begin":7672,"end":7685},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":2239,"end":2244},"obj":"Chemical"},{"id":"T7","span":{"begin":2342,"end":2347},"obj":"Chemical"},{"id":"T8","span":{"begin":2720,"end":2722},"obj":"Chemical"},{"id":"T9","span":{"begin":3192,"end":3196},"obj":"Chemical"},{"id":"T10","span":{"begin":3406,"end":3414},"obj":"Chemical"},{"id":"T11","span":{"begin":3576,"end":3585},"obj":"Chemical"},{"id":"T12","span":{"begin":3859,"end":3867},"obj":"Chemical"},{"id":"T13","span":{"begin":3948,"end":3956},"obj":"Chemical"},{"id":"T14","span":{"begin":4017,"end":4025},"obj":"Chemical"},{"id":"T15","span":{"begin":4089,"end":4098},"obj":"Chemical"},{"id":"T16","span":{"begin":4254,"end":4262},"obj":"Chemical"},{"id":"T17","span":{"begin":4290,"end":4301},"obj":"Chemical"},{"id":"T18","span":{"begin":6389,"end":6396},"obj":"Chemical"},{"id":"T19","span":{"begin":6502,"end":6504},"obj":"Chemical"},{"id":"T20","span":{"begin":6510,"end":6512},"obj":"Chemical"},{"id":"T21","span":{"begin":6527,"end":6539},"obj":"Chemical"},{"id":"T22","span":{"begin":6637,"end":6642},"obj":"Chemical"},{"id":"T23","span":{"begin":6643,"end":6647},"obj":"Chemical"},{"id":"T24","span":{"begin":6701,"end":6708},"obj":"Chemical"},{"id":"T25","span":{"begin":6755,"end":6767},"obj":"Chemical"},{"id":"T26","span":{"begin":6762,"end":6767},"obj":"Chemical"},{"id":"T27","span":{"begin":7858,"end":7873},"obj":"Chemical"},{"id":"T28","span":{"begin":7858,"end":7867},"obj":"Chemical"},{"id":"T29","span":{"begin":7868,"end":7873},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_15841"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_73601"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":33,"end":41},"obj":"Phenotype"},{"id":"T6","span":{"begin":100,"end":108},"obj":"Phenotype"},{"id":"T7","span":{"begin":200,"end":208},"obj":"Phenotype"},{"id":"T8","span":{"begin":210,"end":218},"obj":"Phenotype"},{"id":"T9","span":{"begin":220,"end":231},"obj":"Phenotype"},{"id":"T10","span":{"begin":237,"end":245},"obj":"Phenotype"},{"id":"T11","span":{"begin":298,"end":306},"obj":"Phenotype"},{"id":"T12","span":{"begin":608,"end":616},"obj":"Phenotype"},{"id":"T13","span":{"begin":4971,"end":4992},"obj":"Phenotype"},{"id":"T14","span":{"begin":5361,"end":5370},"obj":"Phenotype"},{"id":"T15","span":{"begin":5381,"end":5401},"obj":"Phenotype"},{"id":"T16","span":{"begin":5757,"end":5765},"obj":"Phenotype"},{"id":"T17","span":{"begin":6083,"end":6091},"obj":"Phenotype"},{"id":"T18","span":{"begin":6093,"end":6101},"obj":"Phenotype"},{"id":"T19","span":{"begin":6255,"end":6263},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002013"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0001944"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002039"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0002086"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0002013"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T11","span":{"begin":1229,"end":1235},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T12","span":{"begin":3454,"end":3478},"obj":"http://purl.obolibrary.org/obo/GO_0002385"},{"id":"T13","span":{"begin":3615,"end":3639},"obj":"http://purl.obolibrary.org/obo/GO_0002250"},{"id":"T14","span":{"begin":3624,"end":3639},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T15","span":{"begin":3905,"end":3920},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T16","span":{"begin":6343,"end":6355},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T17","span":{"begin":6836,"end":6851},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T18","span":{"begin":7472,"end":7481},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T19","span":{"begin":7472,"end":7481},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T20","span":{"begin":7533,"end":7547},"obj":"http://purl.obolibrary.org/obo/GO_0042783"},{"id":"T21","span":{"begin":7665,"end":7678},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T22","span":{"begin":7802,"end":7814},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T23","span":{"begin":8000,"end":8023},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"attributes":[{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":0,"end":2},"obj":"Sentence"},{"id":"T11","span":{"begin":3,"end":15},"obj":"Sentence"},{"id":"T12","span":{"begin":16,"end":342},"obj":"Sentence"},{"id":"T13","span":{"begin":343,"end":432},"obj":"Sentence"},{"id":"T14","span":{"begin":433,"end":508},"obj":"Sentence"},{"id":"T15","span":{"begin":509,"end":597},"obj":"Sentence"},{"id":"T16","span":{"begin":598,"end":663},"obj":"Sentence"},{"id":"T17","span":{"begin":664,"end":794},"obj":"Sentence"},{"id":"T18","span":{"begin":795,"end":1007},"obj":"Sentence"},{"id":"T19","span":{"begin":1008,"end":1137},"obj":"Sentence"},{"id":"T20","span":{"begin":1138,"end":1271},"obj":"Sentence"},{"id":"T21","span":{"begin":1272,"end":1425},"obj":"Sentence"},{"id":"T22","span":{"begin":1426,"end":1658},"obj":"Sentence"},{"id":"T23","span":{"begin":1659,"end":1823},"obj":"Sentence"},{"id":"T24","span":{"begin":1824,"end":1920},"obj":"Sentence"},{"id":"T25","span":{"begin":1921,"end":2012},"obj":"Sentence"},{"id":"T26","span":{"begin":2013,"end":2245},"obj":"Sentence"},{"id":"T27","span":{"begin":2246,"end":2353},"obj":"Sentence"},{"id":"T28","span":{"begin":2354,"end":2513},"obj":"Sentence"},{"id":"T29","span":{"begin":2514,"end":2816},"obj":"Sentence"},{"id":"T30","span":{"begin":2817,"end":2897},"obj":"Sentence"},{"id":"T31","span":{"begin":2898,"end":3033},"obj":"Sentence"},{"id":"T32","span":{"begin":3034,"end":3167},"obj":"Sentence"},{"id":"T33","span":{"begin":3168,"end":3351},"obj":"Sentence"},{"id":"T34","span":{"begin":3352,"end":3540},"obj":"Sentence"},{"id":"T35","span":{"begin":3541,"end":3658},"obj":"Sentence"},{"id":"T36","span":{"begin":3659,"end":3836},"obj":"Sentence"},{"id":"T37","span":{"begin":3837,"end":3979},"obj":"Sentence"},{"id":"T38","span":{"begin":3980,"end":4337},"obj":"Sentence"},{"id":"T39","span":{"begin":4338,"end":4517},"obj":"Sentence"},{"id":"T40","span":{"begin":4518,"end":4741},"obj":"Sentence"},{"id":"T41","span":{"begin":4742,"end":4885},"obj":"Sentence"},{"id":"T42","span":{"begin":4886,"end":5177},"obj":"Sentence"},{"id":"T43","span":{"begin":5178,"end":5276},"obj":"Sentence"},{"id":"T44","span":{"begin":5277,"end":5466},"obj":"Sentence"},{"id":"T45","span":{"begin":5467,"end":5639},"obj":"Sentence"},{"id":"T46","span":{"begin":5640,"end":5895},"obj":"Sentence"},{"id":"T47","span":{"begin":5896,"end":6046},"obj":"Sentence"},{"id":"T48","span":{"begin":6047,"end":6209},"obj":"Sentence"},{"id":"T49","span":{"begin":6210,"end":6275},"obj":"Sentence"},{"id":"T50","span":{"begin":6276,"end":6371},"obj":"Sentence"},{"id":"T51","span":{"begin":6372,"end":6490},"obj":"Sentence"},{"id":"T52","span":{"begin":6491,"end":6611},"obj":"Sentence"},{"id":"T53","span":{"begin":6612,"end":6714},"obj":"Sentence"},{"id":"T54","span":{"begin":6715,"end":6773},"obj":"Sentence"},{"id":"T55","span":{"begin":6774,"end":6860},"obj":"Sentence"},{"id":"T56","span":{"begin":6861,"end":6974},"obj":"Sentence"},{"id":"T57","span":{"begin":6975,"end":7226},"obj":"Sentence"},{"id":"T58","span":{"begin":7227,"end":7462},"obj":"Sentence"},{"id":"T59","span":{"begin":7463,"end":7581},"obj":"Sentence"},{"id":"T60","span":{"begin":7582,"end":7711},"obj":"Sentence"},{"id":"T61","span":{"begin":7712,"end":7909},"obj":"Sentence"},{"id":"T62","span":{"begin":7910,"end":8024},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sentences"},{"subj":"T19","pred":"source","obj":"LitCovid-sentences"},{"subj":"T20","pred":"source","obj":"LitCovid-sentences"},{"subj":"T21","pred":"source","obj":"LitCovid-sentences"},{"subj":"T22","pred":"source","obj":"LitCovid-sentences"},{"subj":"T23","pred":"source","obj":"LitCovid-sentences"},{"subj":"T24","pred":"source","obj":"LitCovid-sentences"},{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"},{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"},{"subj":"T34","pred":"source","obj":"LitCovid-sentences"},{"subj":"T35","pred":"source","obj":"LitCovid-sentences"},{"subj":"T36","pred":"source","obj":"LitCovid-sentences"},{"subj":"T37","pred":"source","obj":"LitCovid-sentences"},{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32403318-22261231-82827216","span":{"begin":425,"end":426},"obj":"22261231"},{"id":"32403318-27261169-82827217","span":{"begin":427,"end":428},"obj":"27261169"},{"id":"32403318-6245603-82827218","span":{"begin":429,"end":430},"obj":"6245603"},{"id":"32403318-888300-82827219","span":{"begin":505,"end":506},"obj":"888300"},{"id":"32403318-103154-82827220","span":{"begin":594,"end":595},"obj":"103154"},{"id":"32403318-83132-82827221","span":{"begin":660,"end":661},"obj":"83132"},{"id":"32403318-22261231-82827222","span":{"begin":998,"end":999},"obj":"22261231"},{"id":"32403318-22840964-82827223","span":{"begin":1000,"end":1001},"obj":"22840964"},{"id":"32403318-23797760-82827224","span":{"begin":1002,"end":1003},"obj":"23797760"},{"id":"32403318-25694517-82827225","span":{"begin":1004,"end":1005},"obj":"25694517"},{"id":"32403318-23963154-82827226","span":{"begin":1133,"end":1135},"obj":"23963154"},{"id":"32403318-25768287-82827227","span":{"begin":1267,"end":1269},"obj":"25768287"},{"id":"32403318-22840964-82827228","span":{"begin":1413,"end":1414},"obj":"22840964"},{"id":"32403318-23963154-82827229","span":{"begin":1415,"end":1417},"obj":"23963154"},{"id":"32403318-22923806-82827230","span":{"begin":1418,"end":1420},"obj":"22923806"},{"id":"32403318-24292967-82827231","span":{"begin":1421,"end":1423},"obj":"24292967"},{"id":"32403318-28947336-82827232","span":{"begin":1518,"end":1520},"obj":"28947336"},{"id":"32403318-16730762-82827233","span":{"begin":2349,"end":2351},"obj":"16730762"},{"id":"32403318-26273575-82827234","span":{"begin":2509,"end":2511},"obj":"26273575"},{"id":"32403318-27261169-82827235","span":{"begin":2813,"end":2814},"obj":"27261169"},{"id":"32403318-29178509-82827236","span":{"begin":3347,"end":3349},"obj":"29178509"},{"id":"32403318-12922142-82827237","span":{"begin":3536,"end":3538},"obj":"12922142"},{"id":"32403318-2853174-82827238","span":{"begin":4327,"end":4329},"obj":"2853174"},{"id":"32403318-3140695-82827239","span":{"begin":4330,"end":4332},"obj":"3140695"},{"id":"32403318-8560773-82827240","span":{"begin":4333,"end":4335},"obj":"8560773"},{"id":"32403318-12690091-82827241","span":{"begin":5269,"end":5271},"obj":"12690091"},{"id":"32403318-12723282-82827242","span":{"begin":5272,"end":5274},"obj":"12723282"},{"id":"32403318-23075143-82827243","span":{"begin":5459,"end":5461},"obj":"23075143"},{"id":"32403318-31668197-82827244","span":{"begin":5462,"end":5464},"obj":"31668197"},{"id":"32403318-31953166-82827245","span":{"begin":5632,"end":5634},"obj":"31953166"},{"id":"32403318-29102111-82827246","span":{"begin":5888,"end":5890},"obj":"29102111"},{"id":"32403318-22278237-82827247","span":{"begin":5891,"end":5893},"obj":"22278237"},{"id":"32403318-22152290-82827248","span":{"begin":6042,"end":6044},"obj":"22152290"},{"id":"32403318-83132-82827249","span":{"begin":6206,"end":6207},"obj":"83132"},{"id":"32403318-17467767-82827250","span":{"begin":6480,"end":6482},"obj":"17467767"},{"id":"32403318-20074871-82827251","span":{"begin":6483,"end":6485},"obj":"20074871"},{"id":"32403318-26907329-82827252","span":{"begin":6486,"end":6488},"obj":"26907329"},{"id":"32403318-18603472-82827253","span":{"begin":6607,"end":6609},"obj":"18603472"},{"id":"32403318-26907329-82827254","span":{"begin":6710,"end":6712},"obj":"26907329"},{"id":"32403318-25787280-82827255","span":{"begin":6769,"end":6771},"obj":"25787280"},{"id":"32403318-26907329-82827256","span":{"begin":6853,"end":6855},"obj":"26907329"},{"id":"32403318-25787280-82827257","span":{"begin":6856,"end":6858},"obj":"25787280"},{"id":"32403318-23486053-82827258","span":{"begin":7219,"end":7221},"obj":"23486053"},{"id":"32403318-23486063-82827259","span":{"begin":7222,"end":7224},"obj":"23486063"},{"id":"32403318-22261231-82827260","span":{"begin":7455,"end":7456},"obj":"22261231"},{"id":"32403318-22840964-82827261","span":{"begin":7457,"end":7458},"obj":"22840964"},{"id":"32403318-23797760-82827262","span":{"begin":7459,"end":7460},"obj":"23797760"}],"attributes":[{"subj":"32403318-22261231-82827216","pred":"source","obj":"2_test"},{"subj":"32403318-27261169-82827217","pred":"source","obj":"2_test"},{"subj":"32403318-6245603-82827218","pred":"source","obj":"2_test"},{"subj":"32403318-888300-82827219","pred":"source","obj":"2_test"},{"subj":"32403318-103154-82827220","pred":"source","obj":"2_test"},{"subj":"32403318-83132-82827221","pred":"source","obj":"2_test"},{"subj":"32403318-22261231-82827222","pred":"source","obj":"2_test"},{"subj":"32403318-22840964-82827223","pred":"source","obj":"2_test"},{"subj":"32403318-23797760-82827224","pred":"source","obj":"2_test"},{"subj":"32403318-25694517-82827225","pred":"source","obj":"2_test"},{"subj":"32403318-23963154-82827226","pred":"source","obj":"2_test"},{"subj":"32403318-25768287-82827227","pred":"source","obj":"2_test"},{"subj":"32403318-22840964-82827228","pred":"source","obj":"2_test"},{"subj":"32403318-23963154-82827229","pred":"source","obj":"2_test"},{"subj":"32403318-22923806-82827230","pred":"source","obj":"2_test"},{"subj":"32403318-24292967-82827231","pred":"source","obj":"2_test"},{"subj":"32403318-28947336-82827232","pred":"source","obj":"2_test"},{"subj":"32403318-16730762-82827233","pred":"source","obj":"2_test"},{"subj":"32403318-26273575-82827234","pred":"source","obj":"2_test"},{"subj":"32403318-27261169-82827235","pred":"source","obj":"2_test"},{"subj":"32403318-29178509-82827236","pred":"source","obj":"2_test"},{"subj":"32403318-12922142-82827237","pred":"source","obj":"2_test"},{"subj":"32403318-2853174-82827238","pred":"source","obj":"2_test"},{"subj":"32403318-3140695-82827239","pred":"source","obj":"2_test"},{"subj":"32403318-8560773-82827240","pred":"source","obj":"2_test"},{"subj":"32403318-12690091-82827241","pred":"source","obj":"2_test"},{"subj":"32403318-12723282-82827242","pred":"source","obj":"2_test"},{"subj":"32403318-23075143-82827243","pred":"source","obj":"2_test"},{"subj":"32403318-31668197-82827244","pred":"source","obj":"2_test"},{"subj":"32403318-31953166-82827245","pred":"source","obj":"2_test"},{"subj":"32403318-29102111-82827246","pred":"source","obj":"2_test"},{"subj":"32403318-22278237-82827247","pred":"source","obj":"2_test"},{"subj":"32403318-22152290-82827248","pred":"source","obj":"2_test"},{"subj":"32403318-83132-82827249","pred":"source","obj":"2_test"},{"subj":"32403318-17467767-82827250","pred":"source","obj":"2_test"},{"subj":"32403318-20074871-82827251","pred":"source","obj":"2_test"},{"subj":"32403318-26907329-82827252","pred":"source","obj":"2_test"},{"subj":"32403318-18603472-82827253","pred":"source","obj":"2_test"},{"subj":"32403318-26907329-82827254","pred":"source","obj":"2_test"},{"subj":"32403318-25787280-82827255","pred":"source","obj":"2_test"},{"subj":"32403318-26907329-82827256","pred":"source","obj":"2_test"},{"subj":"32403318-25787280-82827257","pred":"source","obj":"2_test"},{"subj":"32403318-23486053-82827258","pred":"source","obj":"2_test"},{"subj":"32403318-23486063-82827259","pred":"source","obj":"2_test"},{"subj":"32403318-22261231-82827260","pred":"source","obj":"2_test"},{"subj":"32403318-22840964-82827261","pred":"source","obj":"2_test"},{"subj":"32403318-23797760-82827262","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"141","span":{"begin":16,"end":47},"obj":"Species"},{"id":"142","span":{"begin":49,"end":53},"obj":"Species"},{"id":"143","span":{"begin":177,"end":182},"obj":"Species"},{"id":"144","span":{"begin":249,"end":253},"obj":"Species"},{"id":"145","span":{"begin":419,"end":423},"obj":"Species"},{"id":"146","span":{"begin":768,"end":773},"obj":"Species"},{"id":"147","span":{"begin":857,"end":861},"obj":"Species"},{"id":"148","span":{"begin":1023,"end":1027},"obj":"Species"},{"id":"149","span":{"begin":1197,"end":1201},"obj":"Species"},{"id":"150","span":{"begin":1261,"end":1265},"obj":"Species"},{"id":"151","span":{"begin":1305,"end":1309},"obj":"Species"},{"id":"152","span":{"begin":1365,"end":1370},"obj":"Species"},{"id":"153","span":{"begin":1502,"end":1506},"obj":"Species"},{"id":"154","span":{"begin":1554,"end":1558},"obj":"Species"},{"id":"155","span":{"begin":1611,"end":1615},"obj":"Species"},{"id":"156","span":{"begin":1818,"end":1822},"obj":"Species"},{"id":"157","span":{"begin":1906,"end":1910},"obj":"Species"},{"id":"158","span":{"begin":1954,"end":1958},"obj":"Species"},{"id":"159","span":{"begin":2034,"end":2038},"obj":"Species"},{"id":"160","span":{"begin":2082,"end":2086},"obj":"Species"},{"id":"161","span":{"begin":2729,"end":2733},"obj":"Species"},{"id":"162","span":{"begin":2757,"end":2761},"obj":"Species"},{"id":"163","span":{"begin":2832,"end":2836},"obj":"Species"},{"id":"164","span":{"begin":2982,"end":2986},"obj":"Species"},{"id":"165","span":{"begin":3520,"end":3524},"obj":"Species"},{"id":"166","span":{"begin":3590,"end":3594},"obj":"Species"},{"id":"167","span":{"begin":3704,"end":3708},"obj":"Species"},{"id":"168","span":{"begin":3814,"end":3818},"obj":"Species"},{"id":"169","span":{"begin":3924,"end":3928},"obj":"Species"},{"id":"170","span":{"begin":4192,"end":4196},"obj":"Species"},{"id":"171","span":{"begin":4216,"end":4227},"obj":"Species"},{"id":"172","span":{"begin":4229,"end":4232},"obj":"Species"},{"id":"173","span":{"begin":4321,"end":4325},"obj":"Species"},{"id":"174","span":{"begin":4338,"end":4342},"obj":"Species"},{"id":"175","span":{"begin":4376,"end":4389},"obj":"Species"},{"id":"176","span":{"begin":4538,"end":4542},"obj":"Species"},{"id":"177","span":{"begin":4607,"end":4610},"obj":"Species"},{"id":"178","span":{"begin":4613,"end":4628},"obj":"Species"},{"id":"179","span":{"begin":4630,"end":4635},"obj":"Species"},{"id":"180","span":{"begin":4658,"end":4661},"obj":"Species"},{"id":"181","span":{"begin":4687,"end":4690},"obj":"Species"},{"id":"182","span":{"begin":4742,"end":4746},"obj":"Species"},{"id":"183","span":{"begin":4791,"end":4797},"obj":"Species"},{"id":"184","span":{"begin":4900,"end":4905},"obj":"Species"},{"id":"185","span":{"begin":4943,"end":4947},"obj":"Species"},{"id":"186","span":{"begin":4996,"end":5002},"obj":"Species"},{"id":"187","span":{"begin":5012,"end":5057},"obj":"Species"},{"id":"188","span":{"begin":5059,"end":5067},"obj":"Species"},{"id":"189","span":{"begin":5070,"end":5125},"obj":"Species"},{"id":"190","span":{"begin":5142,"end":5164},"obj":"Species"},{"id":"191","span":{"begin":5166,"end":5175},"obj":"Species"},{"id":"192","span":{"begin":5178,"end":5186},"obj":"Species"},{"id":"193","span":{"begin":5277,"end":5285},"obj":"Species"},{"id":"194","span":{"begin":5467,"end":5476},"obj":"Species"},{"id":"195","span":{"begin":5561,"end":5567},"obj":"Species"},{"id":"196","span":{"begin":5571,"end":5579},"obj":"Species"},{"id":"197","span":{"begin":5610,"end":5616},"obj":"Species"},{"id":"198","span":{"begin":5622,"end":5630},"obj":"Species"},{"id":"199","span":{"begin":5655,"end":5658},"obj":"Species"},{"id":"200","span":{"begin":5674,"end":5705},"obj":"Species"},{"id":"201","span":{"begin":5733,"end":5737},"obj":"Species"},{"id":"202","span":{"begin":5769,"end":5773},"obj":"Species"},{"id":"203","span":{"begin":5783,"end":5787},"obj":"Species"},{"id":"204","span":{"begin":5789,"end":5824},"obj":"Species"},{"id":"205","span":{"begin":5826,"end":5830},"obj":"Species"},{"id":"206","span":{"begin":5847,"end":5879},"obj":"Species"},{"id":"207","span":{"begin":6051,"end":6056},"obj":"Species"},{"id":"208","span":{"begin":6065,"end":6069},"obj":"Species"},{"id":"209","span":{"begin":6190,"end":6195},"obj":"Species"},{"id":"210","span":{"begin":158,"end":165},"obj":"Species"},{"id":"211","span":{"begin":534,"end":541},"obj":"Species"},{"id":"212","span":{"begin":4868,"end":4875},"obj":"Species"},{"id":"213","span":{"begin":5596,"end":5606},"obj":"Species"},{"id":"214","span":{"begin":5725,"end":5732},"obj":"Species"},{"id":"215","span":{"begin":6057,"end":6064},"obj":"Species"},{"id":"216","span":{"begin":5707,"end":5711},"obj":"Species"},{"id":"217","span":{"begin":5881,"end":5885},"obj":"Species"},{"id":"218","span":{"begin":5896,"end":5900},"obj":"Species"},{"id":"219","span":{"begin":6016,"end":6020},"obj":"Species"},{"id":"220","span":{"begin":3185,"end":3196},"obj":"Chemical"},{"id":"221","span":{"begin":100,"end":108},"obj":"Disease"},{"id":"222","span":{"begin":200,"end":208},"obj":"Disease"},{"id":"223","span":{"begin":210,"end":218},"obj":"Disease"},{"id":"224","span":{"begin":220,"end":231},"obj":"Disease"},{"id":"225","span":{"begin":237,"end":245},"obj":"Disease"},{"id":"226","span":{"begin":298,"end":306},"obj":"Disease"},{"id":"227","span":{"begin":316,"end":325},"obj":"Disease"},{"id":"228","span":{"begin":393,"end":402},"obj":"Disease"},{"id":"229","span":{"begin":602,"end":616},"obj":"Disease"},{"id":"230","span":{"begin":967,"end":976},"obj":"Disease"},{"id":"231","span":{"begin":1161,"end":1170},"obj":"Disease"},{"id":"232","span":{"begin":1202,"end":1211},"obj":"Disease"},{"id":"233","span":{"begin":1507,"end":1516},"obj":"Disease"},{"id":"234","span":{"begin":2102,"end":2111},"obj":"Disease"},{"id":"235","span":{"begin":3525,"end":3534},"obj":"Disease"},{"id":"236","span":{"begin":4971,"end":4992},"obj":"Disease"},{"id":"237","span":{"begin":5221,"end":5240},"obj":"Disease"},{"id":"238","span":{"begin":5361,"end":5370},"obj":"Disease"},{"id":"239","span":{"begin":5375,"end":5410},"obj":"Disease"},{"id":"240","span":{"begin":5412,"end":5416},"obj":"Disease"},{"id":"241","span":{"begin":5441,"end":5450},"obj":"Disease"},{"id":"242","span":{"begin":5751,"end":5765},"obj":"Disease"},{"id":"243","span":{"begin":6083,"end":6091},"obj":"Disease"},{"id":"244","span":{"begin":6093,"end":6101},"obj":"Disease"},{"id":"245","span":{"begin":6107,"end":6116},"obj":"Disease"},{"id":"270","span":{"begin":6372,"end":6388},"obj":"Gene"},{"id":"271","span":{"begin":6398,"end":6401},"obj":"Gene"},{"id":"272","span":{"begin":6491,"end":6494},"obj":"Gene"},{"id":"273","span":{"begin":6612,"end":6615},"obj":"Gene"},{"id":"274","span":{"begin":6726,"end":6729},"obj":"Gene"},{"id":"275","span":{"begin":6210,"end":6214},"obj":"Species"},{"id":"276","span":{"begin":6338,"end":6342},"obj":"Species"},{"id":"277","span":{"begin":6465,"end":6469},"obj":"Species"},{"id":"278","span":{"begin":6474,"end":6478},"obj":"Species"},{"id":"279","span":{"begin":6731,"end":6735},"obj":"Species"},{"id":"280","span":{"begin":6801,"end":6805},"obj":"Species"},{"id":"281","span":{"begin":6861,"end":6865},"obj":"Species"},{"id":"282","span":{"begin":6944,"end":6949},"obj":"Species"},{"id":"283","span":{"begin":6958,"end":6963},"obj":"Species"},{"id":"284","span":{"begin":6990,"end":6994},"obj":"Species"},{"id":"285","span":{"begin":7268,"end":7272},"obj":"Species"},{"id":"286","span":{"begin":7582,"end":7586},"obj":"Species"},{"id":"287","span":{"begin":7896,"end":7900},"obj":"Species"},{"id":"288","span":{"begin":7904,"end":7908},"obj":"Species"},{"id":"289","span":{"begin":7981,"end":7985},"obj":"Species"},{"id":"290","span":{"begin":6755,"end":6767},"obj":"Chemical"},{"id":"291","span":{"begin":6249,"end":6263},"obj":"Disease"},{"id":"292","span":{"begin":6836,"end":6851},"obj":"Disease"},{"id":"293","span":{"begin":7196,"end":7204},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"Tax:28295"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"Tax:28295"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"Tax:9823"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"Tax:9823"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"Tax:9823"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"Tax:9823"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"Tax:28295"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"Tax:28295"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"Tax:28295"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"Tax:9823"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"Tax:28295"},{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Tax:9823"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Tax:28295"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Tax:28295"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Tax:9823"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Tax:28295"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Tax:28295"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"Tax:28295"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"Tax:28295"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"Tax:28295"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Tax:28295"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"Tax:28295"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"Tax:28295"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Tax:28295"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Tax:28295"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Tax:28295"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Tax:28295"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Tax:28295"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Tax:9823"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"Tax:28295"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"Tax:11118"},{"id":"A172","pred":"tao:has_database_id","subj":"172","obj":"Tax:11118"},{"id":"A173","pred":"tao:has_database_id","subj":"173","obj":"Tax:11118"},{"id":"A174","pred":"tao:has_database_id","subj":"174","obj":"Tax:11118"},{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Tax:11118"},{"id":"A176","pred":"tao:has_database_id","subj":"176","obj":"Tax:11118"},{"id":"A177","pred":"tao:has_database_id","subj":"177","obj":"Tax:11118"},{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"Tax:694002"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"Tax:694002"},{"id":"A180","pred":"tao:has_database_id","subj":"180","obj":"Tax:11118"},{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"Tax:11118"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"Tax:11118"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"Tax:9606"},{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"Tax:694002"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"Tax:11118"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"Tax:9606"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Tax:694009"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"Tax:694009"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"Tax:1335626"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Tax:2697049"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Tax:2697049"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Tax:694009"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"Tax:1335626"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Tax:2697049"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Tax:9606"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Tax:694009"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"Tax:9606"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Tax:694009"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Tax:11118"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Tax:11146"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Tax:11118"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Tax:9823"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Tax:28295"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"Tax:11149"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Tax:11149"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"Tax:2018513"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Tax:9823"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"Tax:11118"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"Tax:9823"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Tax:28293"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"Tax:28293"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"Tax:28293"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"Tax:11120"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"Tax:28293"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"Tax:28293"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"Tax:11146"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Tax:2018513"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Tax:11146"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Tax:11146"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"MESH:D019344"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"MESH:D003967"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"MESH:D014839"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D003967"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"MESH:D003681"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"MESH:D000855"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"MESH:D003967"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"MESH:D003643"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"MESH:D003643"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"MESH:D003643"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"MESH:D003643"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"MESH:D007239"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:D007239"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D003643"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D007239"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D012140"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D012140"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"MESH:D011014"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"MESH:D012128"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"MESH:D012128"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"MESH:D003643"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"MESH:D003967"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"MESH:D014839"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"MESH:D003643"},{"id":"A270","pred":"tao:has_database_id","subj":"270","obj":"Gene:290"},{"id":"A271","pred":"tao:has_database_id","subj":"271","obj":"Gene:290"},{"id":"A272","pred":"tao:has_database_id","subj":"272","obj":"Gene:290"},{"id":"A273","pred":"tao:has_database_id","subj":"273","obj":"Gene:290"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"Gene:290"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"Tax:28295"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"Tax:28295"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"Tax:28295"},{"id":"A278","pred":"tao:has_database_id","subj":"278","obj":"Tax:11149"},{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"Tax:28295"},{"id":"A280","pred":"tao:has_database_id","subj":"280","obj":"Tax:28295"},{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"Tax:28295"},{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"Tax:9606"},{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"Tax:9606"},{"id":"A284","pred":"tao:has_database_id","subj":"284","obj":"Tax:28295"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"Tax:28295"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"Tax:28295"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Tax:28295"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Tax:9823"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Tax:28295"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"MESH:D012794"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"MESH:D001102"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:D015047"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"154","pred":"source","obj":"LitCovid-PubTator"},{"subj":"155","pred":"source","obj":"LitCovid-PubTator"},{"subj":"156","pred":"source","obj":"LitCovid-PubTator"},{"subj":"157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"160","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"},{"subj":"162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"167","pred":"source","obj":"LitCovid-PubTator"},{"subj":"168","pred":"source","obj":"LitCovid-PubTator"},{"subj":"169","pred":"source","obj":"LitCovid-PubTator"},{"subj":"170","pred":"source","obj":"LitCovid-PubTator"},{"subj":"171","pred":"source","obj":"LitCovid-PubTator"},{"subj":"172","pred":"source","obj":"LitCovid-PubTator"},{"subj":"173","pred":"source","obj":"LitCovid-PubTator"},{"subj":"174","pred":"source","obj":"LitCovid-PubTator"},{"subj":"175","pred":"source","obj":"LitCovid-PubTator"},{"subj":"176","pred":"source","obj":"LitCovid-PubTator"},{"subj":"177","pred":"source","obj":"LitCovid-PubTator"},{"subj":"178","pred":"source","obj":"LitCovid-PubTator"},{"subj":"179","pred":"source","obj":"LitCovid-PubTator"},{"subj":"180","pred":"source","obj":"LitCovid-PubTator"},{"subj":"181","pred":"source","obj":"LitCovid-PubTator"},{"subj":"182","pred":"source","obj":"LitCovid-PubTator"},{"subj":"183","pred":"source","obj":"LitCovid-PubTator"},{"subj":"184","pred":"source","obj":"LitCovid-PubTator"},{"subj":"185","pred":"source","obj":"LitCovid-PubTator"},{"subj":"186","pred":"source","obj":"LitCovid-PubTator"},{"subj":"187","pred":"source","obj":"LitCovid-PubTator"},{"subj":"188","pred":"source","obj":"LitCovid-PubTator"},{"subj":"189","pred":"source","obj":"LitCovid-PubTator"},{"subj":"190","pred":"source","obj":"LitCovid-PubTator"},{"subj":"191","pred":"source","obj":"LitCovid-PubTator"},{"subj":"192","pred":"source","obj":"LitCovid-PubTator"},{"subj":"193","pred":"source","obj":"LitCovid-PubTator"},{"subj":"194","pred":"source","obj":"LitCovid-PubTator"},{"subj":"195","pred":"source","obj":"LitCovid-PubTator"},{"subj":"196","pred":"source","obj":"LitCovid-PubTator"},{"subj":"197","pred":"source","obj":"LitCovid-PubTator"},{"subj":"198","pred":"source","obj":"LitCovid-PubTator"},{"subj":"199","pred":"source","obj":"LitCovid-PubTator"},{"subj":"200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"209","pred":"source","obj":"LitCovid-PubTator"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"213","pred":"source","obj":"LitCovid-PubTator"},{"subj":"214","pred":"source","obj":"LitCovid-PubTator"},{"subj":"215","pred":"source","obj":"LitCovid-PubTator"},{"subj":"216","pred":"source","obj":"LitCovid-PubTator"},{"subj":"217","pred":"source","obj":"LitCovid-PubTator"},{"subj":"218","pred":"source","obj":"LitCovid-PubTator"},{"subj":"219","pred":"source","obj":"LitCovid-PubTator"},{"subj":"220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"221","pred":"source","obj":"LitCovid-PubTator"},{"subj":"222","pred":"source","obj":"LitCovid-PubTator"},{"subj":"223","pred":"source","obj":"LitCovid-PubTator"},{"subj":"224","pred":"source","obj":"LitCovid-PubTator"},{"subj":"225","pred":"source","obj":"LitCovid-PubTator"},{"subj":"226","pred":"source","obj":"LitCovid-PubTator"},{"subj":"227","pred":"source","obj":"LitCovid-PubTator"},{"subj":"228","pred":"source","obj":"LitCovid-PubTator"},{"subj":"229","pred":"source","obj":"LitCovid-PubTator"},{"subj":"230","pred":"source","obj":"LitCovid-PubTator"},{"subj":"231","pred":"source","obj":"LitCovid-PubTator"},{"subj":"232","pred":"source","obj":"LitCovid-PubTator"},{"subj":"233","pred":"source","obj":"LitCovid-PubTator"},{"subj":"234","pred":"source","obj":"LitCovid-PubTator"},{"subj":"235","pred":"source","obj":"LitCovid-PubTator"},{"subj":"236","pred":"source","obj":"LitCovid-PubTator"},{"subj":"237","pred":"source","obj":"LitCovid-PubTator"},{"subj":"238","pred":"source","obj":"LitCovid-PubTator"},{"subj":"239","pred":"source","obj":"LitCovid-PubTator"},{"subj":"240","pred":"source","obj":"LitCovid-PubTator"},{"subj":"241","pred":"source","obj":"LitCovid-PubTator"},{"subj":"242","pred":"source","obj":"LitCovid-PubTator"},{"subj":"243","pred":"source","obj":"LitCovid-PubTator"},{"subj":"244","pred":"source","obj":"LitCovid-PubTator"},{"subj":"245","pred":"source","obj":"LitCovid-PubTator"},{"subj":"270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"273","pred":"source","obj":"LitCovid-PubTator"},{"subj":"274","pred":"source","obj":"LitCovid-PubTator"},{"subj":"275","pred":"source","obj":"LitCovid-PubTator"},{"subj":"276","pred":"source","obj":"LitCovid-PubTator"},{"subj":"277","pred":"source","obj":"LitCovid-PubTator"},{"subj":"278","pred":"source","obj":"LitCovid-PubTator"},{"subj":"279","pred":"source","obj":"LitCovid-PubTator"},{"subj":"280","pred":"source","obj":"LitCovid-PubTator"},{"subj":"281","pred":"source","obj":"LitCovid-PubTator"},{"subj":"282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"286","pred":"source","obj":"LitCovid-PubTator"},{"subj":"287","pred":"source","obj":"LitCovid-PubTator"},{"subj":"288","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"290","pred":"source","obj":"LitCovid-PubTator"},{"subj":"291","pred":"source","obj":"LitCovid-PubTator"},{"subj":"292","pred":"source","obj":"LitCovid-PubTator"},{"subj":"293","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#eaec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#d493ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecba"},{"id":"LitCovid-PD-CLO","color":"#eca093"},{"id":"LitCovid-PD-CHEBI","color":"#939fec"},{"id":"LitCovid-PD-HP","color":"#b9ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93d3"},{"id":"LitCovid-sentences","color":"#93ecea"},{"id":"2_test","color":"#ecd093"},{"id":"LitCovid-PubTator","color":"#b693ec"}]}]}}